Cited by 1,632Hemoglobin structure and functionCircadian rhythm and melatoninRedox biology and oxidative stress

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PAS Domains: Internal Sensors of Oxygen, Redox Potential, and Light

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Taylor, Barry L., Zhulin, Igor B.·1999·Microbiology and Molecular Biology Reviews

DOI 10.1128/mmbr.63.2.479-506.1999PMC PMC98974

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Abstract

SUMMARY: PAS domains are newly recognized signaling domains that are widely distributed in proteins from members of the Archaea and Bacteria and from fungi, plants, insects, and vertebrates. They function as input modules in proteins that sense oxygen, redox potential, light, and some other stimuli. Specificity in sensing arises, in part, from different cofactors that may be associated with the PAS fold. Transduction of redox signals may be a common mechanistic theme in many different PAS domains. PAS proteins are always located intracellularly but may monitor the external as well as the internal environment. One way in which prokaryotic PAS proteins sense the environment is by detecting changes in the electron transport system. This serves as an early warning system for any reduction in cellular energy levels. Human PAS proteins include hypoxia-inducible factors and voltage-sensitive ion channels; other PAS proteins are integral components of circadian clocks. Although PAS domains were only recently identified, the signaling functions with which they are associated have long been recognized as fundamental properties of living cells.

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Authors: Taylor, B. L., & Zhulin, I. B.
Affiliations: Loma Linda University (US)
Department of Microbiology and Molecular Genetics1 and
ORCID: Zhulin, Igor B.
Venue: Microbiology and Molecular Biology Reviews
Publisher: American Society for Microbiology
Published: 1999-06
Volume: 63
Issue: 2
Pages: 479-506
ISSN: 1092-2172 (ISSN-L)
1098-5557
DOI: 10.1128/mmbr.63.2.479-506.1999
PMC: PMC98974
OpenAlex: W2122023734
Cited by: 1,632
References: 269
Citations by year: 2026: 19 · 2025: 36 · 2024: 31 · 2023: 37 · 2022: 30 · 2021: 51 · 2020: 49 · 2019: 55 · 2018: 44 · 2017: 45 · 2016: 39 · 2015: 55 · 2014: 71 · 2013: 61 · 2012: 63
FWCI: 5.55
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Microbiology and Molecular Biology Reviews (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (GM-29481, R01GM029481)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: PAS domain, oxygen sensing, redox signaling, optical sensing, signal transduction, cofactors, electron transport, hypoxia-inducible factor, voltage-gated ion channels, circadian clock
MeSH terms: Amino Acid Sequence, Animals, DNA-Binding Proteins, Electron Transport, Eukaryotic Cells, Humans, Light, Molecular Sequence Data, Oxidation-Reduction, Oxygen, Prokaryotic Cells, Potassium Channels, Signal Transduction, Sequence Alignment, Helix-Loop-Helix Motifs, Bacterial Physiological Phenomena

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PAS Domains: Internal Sensors of Oxygen, Redox Potential, and Light

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