Cited by 1,632Hemoglobin structure and functionCircadian rhythm and melatoninRedox biology and oxidative stress

The DOI matches its Crossref record; 269 of the 269 references it cites were found in a registry or an index.

PAS Domains: Internal Sensors of Oxygen, Redox Potential, and Light

Open access
Taylor, Barry L., Zhulin, Igor B.·1999·Microbiology and Molecular Biology Reviews

Abstract

SUMMARY: PAS domains are newly recognized signaling domains that are widely distributed in proteins from members of the Archaea and Bacteria and from fungi, plants, insects, and vertebrates. They function as input modules in proteins that sense oxygen, redox potential, light, and some other stimuli. Specificity in sensing arises, in part, from different cofactors that may be associated with the PAS fold. Transduction of redox signals may be a common mechanistic theme in many different PAS domains. PAS proteins are always located intracellularly but may monitor the external as well as the internal environment. One way in which prokaryotic PAS proteins sense the environment is by detecting changes in the electron transport system. This serves as an early warning system for any reduction in cellular energy levels. Human PAS proteins include hypoxia-inducible factors and voltage-sensitive ion channels; other PAS proteins are integral components of circadian clocks. Although PAS domains were only recently identified, the signaling functions with which they are associated have long been recognized as fundamental properties of living cells.

Overview

Integrity signals

Registry

Crossref · 10.1128/mmbr.63.2.479-506.1999

Cites

269 of 269 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

1 retracted

Research works printed but not linked: 2

  1. 10.1016/S0022-2836(05)80360-2 · DOI · Paper page
  2. Lynch A. S. Lin E. C. C. Responses to molecular oxygen Escherichia coli and Salmonella: cellular and molecular biology 2nd ed. Neidhardt F. C. Curtiss R. III Ingraham J. L. Lin E. C. C. Low K. B. Magasanik B. Reznikoff W. S. Riley M. Schaechter M. Umbarger H. E. 1 1996 1526 1538 ASM Press Washington, D.C

Cited by

Sorted by citations

See all 1,632

Metadata

Authors
Taylor, B. L., & Zhulin, I. B.
Affiliations
  • Loma Linda University (US)
  • <!--label omitted: 1-->Department of Microbiology and Molecular Genetics1 and
Venue
Microbiology and Molecular Biology Reviews
Published
1999-06
Volume
63
Issue
2
Pages
479-506
ISSN
  • 1092-2172 (ISSN-L)
  • 1098-5557
OpenAlex
W2122023734
Cited by
1,632
References
269
Citations by year
2026: 19 · 2025: 36 · 2024: 31 · 2023: 37 · 2022: 30 · 2021: 51 · 2020: 49 · 2019: 55 · 2018: 44 · 2017: 45 · 2016: 39 · 2015: 55 · 2014: 71 · 2013: 61 · 2012: 63
FWCI
5.55
Type
journal article
Language
en
Open access
Locations
  • Microbiology and Molecular Biology Reviews (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of General Medical Sciences (GM-29481, R01GM029481)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
PAS domain, oxygen sensing, redox signaling, optical sensing, signal transduction, cofactors, electron transport, hypoxia-inducible factor, voltage-gated ion channels, circadian clock
MeSH terms
Amino Acid Sequence, Animals, DNA-Binding Proteins, Electron Transport, Eukaryotic Cells, Humans, Light, Molecular Sequence Data, Oxidation-Reduction, Oxygen, Prokaryotic Cells, Potassium Channels, Signal Transduction, Sequence Alignment, Helix-Loop-Helix Motifs, Bacterial Physiological Phenomena

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review