Cited by 1,136Fungal and yeast genetics researchBacterial Genetics and BiotechnologyProtein Kinase Regulation and GTPase Signaling

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Cell Wall Integrity Signaling in Saccharomyces cerevisiae

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Levin, David E.·2005·Microbiology and Molecular Biology Reviews

DOI 10.1128/mmbr.69.2.262-291.2005PMC PMC1197416

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Abstract

SUMMARY: The yeast cell wall is a highly dynamic structure that is responsible for protecting the cell from rapid changes in external osmotic potential. The wall is also critical for cell expansion during growth and morphogenesis. This review discusses recent advances in understanding the various signal transduction pathways that allow cells to monitor the state of the cell wall and respond to environmental challenges to this structure. The cell wall integrity signaling pathway controlled by the small G-protein Rho1 is principally responsible for orchestrating changes to the cell wall periodically through the cell cycle and in response to various forms of cell wall stress. This signaling pathway acts through direct control of wall biosynthetic enzymes, transcriptional regulation of cell wall-related genes, and polarization of the actin cytoskeleton. However, additional signaling pathways interface both with the cell wall integrity signaling pathway and with the actin cytoskeleton to coordinate polarized secretion with cell wall expansion. These include Ca 2+ signaling, phosphatidylinositide signaling at the plasma membrane, sphingoid base signaling through the Pkh1 and -2 protein kinases, Tor kinase signaling, and pathways controlled by the Rho3, Rho4, and Cdc42 G-proteins.

Integrity signals

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Crossref · 10.1128/mmbr.69.2.262-291.2005

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See all 1,136

Authors: Levin, D. E.
Affiliations: Johns Hopkins University (US)
Corresponding author: Levin, David E.
ORCID: Levin, David E.
Venue: Microbiology and Molecular Biology Reviews
Publisher: American Society for Microbiology
Published: 2005-06
Volume: 69
Issue: 2
Pages: 262-291
ISSN: 1092-2172 (ISSN-L)
1098-5557
DOI: 10.1128/mmbr.69.2.262-291.2005
PMC: PMC1197416
OpenAlex: W2157937554
Cited by: 1,136
References: 390
Citations by year: 2026: 35 · 2025: 34 · 2024: 45 · 2023: 32 · 2022: 43 · 2021: 44 · 2020: 36 · 2019: 48 · 2018: 51 · 2017: 40 · 2016: 48 · 2015: 49 · 2014: 66 · 2013: 53 · 2012: 76
FWCI: 5.53
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Microbiology and Molecular Biology Reviews (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of General Medical Sciences (GM48533, R01GM048533)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords: cell wall integrity signaling, Saccharomyces cerevisiae, cell wall stress, osmotic stress, cell wall expansion, polarized secretion, calcium signaling, phosphoinositide signaling, Cdc42, cell wall biosynthesis, transcriptional regulation
MeSH terms: Cell Wall, Enzyme Activation, Protein Kinase C, Saccharomyces cerevisiae, Signal Transduction, Drug Delivery Systems, rho GTP-Binding Proteins, Mitogen-Activated Protein Kinases, Saccharomyces cerevisiae Proteins

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Cell Wall Integrity Signaling in Saccharomyces cerevisiae

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