Cited by 42Antifungal resistance and susceptibilityFungal and yeast genetics researchFungal Plant Pathogen Control

Triazole Evolution of Candida parapsilosis Results in Cross-Resistance to Other Antifungal Drugs, Influences Stress Responses, and Alters Virulence in an Antifungal Drug-Dependent Manner

Open access
Papp, Csaba, Bohner, Flóra, Kocsis, Katica, Varga, Mónika, Szekeres, András, Bodai, László, Willis, Jesse R., Gabaldón, Toni +4 more·2020·mSphere

Abstract

Candida parapsilosis causes life-threatening fungal infections. In the last 2 decades, the increasing number of azole-resistant C. parapsilosis clinical isolates has been attributable to the overuse and misuse of fluconazole, the first-line antifungal agent most commonly used in several countries. To date, the range of applicable antifungal drugs is limited. As a consequence, it is essential to understand the possible mechanisms of antifungal resistance development and their effect on virulence in order to optimize antifungal treatment strategies in the clinical setting. Our results revealed that the prolonged exposure to azoles resulted not only in azole resistance but also in cross-resistance development. Our data further indicate that resistance development may occur through different mechanisms that can also alter the virulence of C. parapsilosis . These results highlight the consequences of prolonged drug usage and suggest the need for developing alternative antifungal treatment strategies in clinical practice.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1128/msphere.00821-20

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In C. parapsilosis, mutations in ERG3 have been reported in strains resistant to azoles and echinocandins.

    “In the related pathogen Candida parapsilosis, mutations in ERG3 have been reported in strains resistant to azoles and echinocandins80.”

    From Molecular mechanisms governing antifungal drug resistance (2023) · cites this paper as [80]

  • ERG3 mutations leading to depletion of ergosterol and accumulation of less toxic sterols when ERG11 is inhibited have been implicated in cross-resistance between azoles and polyenes in S. cerevisiae and C. albicans and between echinocandins and azoles in C. parapsilosis.

    “ERG3 mutations leading to the depletion of ergosterol and the accumulation of less toxic sterols when ERG11 is inhibited have been implicated in cross-resistance between azoles and polyenes in S. cerevisiae and C. albicans40, 41, 42, 43 and between echinocandins and azoles in C. parapsilosis.44,45”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Papp, C., Bohner, F., Kocsis, K., Varga, M., Szekeres, A., Bodai, L., Willis, J. R., Gabaldón, T., Tóth, R., Nosanchuk, J. D., Vágvölgyi, C., & Gácser, A.
Affiliations
  • University of Szeged (HU)
  • Barcelona Supercomputing Center (ES)
  • Institució Catalana de Recerca i Estudis Avançats (ES)
  • Albert Einstein College of Medicine (US)
Corresponding author
Gácser, Attila
Venue
mSphere
Published
2020-10-28
Volume
5
Issue
5
ISSN
2379-5042 (ISSN-L)
OpenAlex
W3097824442
Cited by
42
References
46
Citations by year
2026: 6 · 2025: 4 · 2024: 8 · 2023: 8 · 2022: 7 · 2021: 9
FWCI
0.79
Type
journal article
Language
en
Open access
Locations
  • mSphere (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • SZTE Publicatio Repozitórium (University of Szeged) (acceptedVersion, other-oa)
  • Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (acceptedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • UPCommons institutional repository (Universitat Politècnica de Catalunya) (submittedVersion, cc-by)
Funders
  • GINOP (GINOP-2.3.2.-15-2016-00035)
  • Magyar Tudományos Akadémia (BO/00522/19/8, LP2018-15/2018)
  • Magyarország Kormánya (3/2018/FEKUSTRAT)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
Keywords
Candida parapsilosis, azole resistance, fluconazole, cross-resistance, antifungal resistance, stress response, virulence
MeSH terms
Candida parapsilosis, Animals, Antifungal Agents, Candidiasis, Female, Mice, Inbred BALB C, Microbial Sensitivity Tests, Stress, Physiological, Triazoles, Evolution, Molecular, Drug Resistance, Fungal, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review