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Do mitochondria have an immune system?

Popkov, V. A., Zorova, L. D., Korvigo, I. O., Silachev, D. N., Jankauskas, S. S., Babenko, V. A., Pevzner, I. B., Danilina, T. I., Zorov, S. D., Plotnikov, E. Y., Zorov, D. B.·2016·Biochemistry (Moscow)
DOI 10.1134/s0006297916100217
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Abstract

The question if mitochondria have some kind of immune system is not trivial. The basis for raising this question is the fact that bacteria, which are progenitors of mitochondria, do have an immune system. The CRISPR system in bacteria based on the principle of RNA interference serves as an organized mechanism for destroying alien nucleic acids, primarily those of viral origin. We have shown that mitochondria are also a target for viral attacks, probably due to a related organization of genomes in these organelles and bacteria. Bioinformatic analysis performed in this study has not given a clear answer if there is a CRISPR-like immune system in mitochondria. However, this does not preclude the possibility of mitochondrial immunity that can be difficult to decipher or that is based on some principles other than those of CRISPR.

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Metadata

Authors
Popkov, V. A., Zorova, L. D., Korvigo, I. O., Silachev, D. N., Jankauskas, S. S., Babenko, V. A., Pevzner, I. B., Danilina, T. I., Zorov, S. D., Plotnikov, E. Y., & Zorov, D. B.
Venue
Biochemistry (Moscow)
Publisher
Pleiades Publishing Ltd
Published
2016-10
Volume
81
Issue
10
Pages
1229-1236
ISSN
  • 0006-2979
  • 1608-3040
DOI
10.1134/s0006297916100217
Cited by
5
References
1
Language
en
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