Cited by 316interferon and immune responsesImmune Response and InflammationMitochondrial Function and Pathology

Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway

Open access
Castanier, Céline, Garcin, Dominique, Vazquez, Aimé, Arnoult, Damien·2010·The EMBO Reports

Abstract

The intracellular retinoic acid-inducible gene I-like receptors (RLRs) sense viral ribonucleic acid and signal through the mitochondrial protein mitochondrial antiviral signalling (MAVS) to trigger the production of type I interferons and proinflammatory cytokines. In this study, we report that RLR activation promotes elongation of the mitochondrial network. Mimicking this elongation enhances signalling downstream from MAVS and favours the binding of MAVS to stimulator of interferon genes, an endoplasmic reticulum (ER) protein involved in the RLR pathway. By contrast, enforced mitochondrial fragmentation dampens signalling and reduces the association between both proteins. Our finding that MAVS is associated with a pool of mitofusin 1, a protein of the mitochondrial fusion machinery, suggests that MAVS is capable of regulating mitochondrial dynamics to facilitate the mitochondria-ER association required for signal transduction. Importantly, we observed that viral mitochondria-localized inhibitor of apoptosis, a cytomegalovirus (CMV) antiapoptotic protein that promotes mitochondrial fragmentation, inhibits signalling downstream from MAVS, suggesting a possible new immune modulation strategy of the CMV.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/embor.2009.258

Cites

17 of 17 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Mitochondrial fusion promotes RLR signaling, whereas mitochondrial fission inhibits it.

    “Multiple studies have demonstrated that mitochondrial fusion promotes, whereas mitochondrial fission inhibits RLR signaling (Castanier et al., 2010; Yasukawa et al., 2009; Zhao et al., 2012).”

    From Mitochondria in the Regulation of Innate and Adaptive Immunity (2015) · cites this paper as Castanier et al., 2010

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Castanier, C., Garcin, D., Vazquez, A., & Arnoult, D.
Affiliations
  • Université Paris-Sud (FR)
  • University of Geneva (CH)
Corresponding author
Arnoult, Damien
Venue
The EMBO Reports
Published
2009-12-18
Volume
11
Issue
2
Pages
133-138
ISSN
  • 1469-221X (ISSN-L)
  • 1469-3178
OpenAlex
W1993205112
Cited by
316
References
17
Citations by year
2026: 10 · 2025: 18 · 2024: 14 · 2023: 20 · 2022: 19 · 2021: 26 · 2020: 27 · 2019: 23 · 2018: 19 · 2017: 20 · 2016: 16 · 2015: 17 · 2014: 22 · 2013: 11 · 2012: 20
FWCI
7.62
Type
journal article
Language
en
Open access
Locations
  • EMBO Reports (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords
mitochondrial dynamics, RIG-I-like receptors, MAVS, mitochondrial fusion, mitofusin 1, mitochondrial fragmentation, STING, type I interferon signaling, viral RNA sensing, cytomegalovirus, immune evasion, antiviral innate immunity
MeSH terms
STING Protein, Antiviral Agents, Cells, Cultured, HeLa Cells, Humans, Immunity, Innate, Membrane Proteins, Mitochondria, Protein Binding, Virus Diseases, Signal Transduction, Receptors, Retinoic Acid, Mitochondrial Proteins, Organelle Shape, Organelle Size

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review