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Mitochondria with Morphology Characteristic for Alzheimer’s Disease Patients Are Found in the Brain of OXYS Rats
Abstract
Growing evidence suggests that mitochondrial dysfunction is closely linked to the pathogenesis of sporadic Alzheimer's disease (AD). One of the key contributors to various aspects of AD pathogenesis, along with metabolic dysfunction, is mitochondrial dynamics, involving balance between fusion and fission, which regulates mitochondrial number and morphology in response to changes in cellular energy demand. Recently, Zhang et al. ((2016) Sci. Rep., 6, 18725) described a previously unknown mitochondrial phenotype manifesting as elongated chain-linked mitochondria termed "mitochondria-on-a-string" (MOAS) in brain tissue from AD patients and mouse models of AD. The authors associated this phenotype with fission arrest, but implications of MOAS formation in AD pathogenesis remain to be understood. Here we analyze the presence and number of MOAS in the brain of OXYS rats simulating key signs of sporadic AD. Using electron microscopy, we found MOAS in OXYS prefrontal cortex neuropil in all stages of AD-like pathology, including manifestation (5-month-old rats) and progression (12-18-month-old rats). The most pronounced elevation of MOAS content (8-fold) in OXYS rats compared to Wistar controls was found at the preclinical stage (20 days) on the background of decreased numbers of non-MOAS elongated mitochondria. From the age of 20 days through 18 months, the percentage of MOAS-containing neuronal processes increased from 1.7 to 8.3% in Wistar and from 13.9 to 16% in OXYS rats. Our res…
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MOAS were observed within the dendritic shafts of glutamatergic-like pyramidal neurons within layer III of the dlPFC of aged rhesus macaques.
“we have observed MOAS within the dendritic shafts of glutamatergic-like pyramidal neurons within layer III of the dlPFC of aged rhesus macaques”
From Chronic Stress Weakens Connectivity in the Prefrontal Cortex: Architectural and Molecular Changes. (2021) · cites this paper as [225]
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Metadata
- Authors
- Tyumentsev, M. A., Stefanova, N. A., Kiseleva, E. V., & Kolosova, N. G.
- Affiliations
- Institute of Cytology and Genetics (RU)
- Novosibirsk State University (RU)
- Corresponding author
- Kolosova, N. G.
- Venue
- Biochemistry (Moscow)
- Publisher
- Pleiades Publishing Ltd
- Published
- 2018-09
- Volume
- 83
- Issue
- 9
- Pages
- 1083-1088
- ISSN
- 0006-2979 (ISSN-L)
- 1608-3040
- OpenAlex
- W2891306021
- Cited by
- 28
- References
- 18
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 5 · 2021: 2 · 2020: 5 · 2019: 4
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biochemistry (Moscow) (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Russian Academy of Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- Alzheimer's disease, mitochondrial dynamics, mitochondrial fission, mitochondrial fusion, mitochondrial dysfunction, OXYS rats, prefrontal cortex, neural processes, preclinical Alzheimer's disease, sporadic Alzheimer's disease
- MeSH terms
- Alzheimer Disease, Animals, Axons, Brain, Disease Models, Animal, Humans, Male, Microscopy, Electron, Mitochondria, Rats, Wistar, Rats, Mitochondrial Dynamics
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