Alzheimer’s Disease-Like Pathology in Senescence-Accelerated OXYS Rats Can Be Partially Retarded with Mitochondria-Targeted Antioxidant SkQ1
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We previously showed that mitochondria-targeted antioxidant SkQ1 (plastoquinonyl-decyltriphenylphosphonium) at nanomolar concentrations is capable of preventing and slowing down some cerebral dysfunctions in accelerated-senescence OXYS rats. Here we demonstrate that OXYS rats develop behavior, learning, and memory deficits against a background of neurodegeneration signs detected by magnetic resonance tomography and amyloid-β (Aβ) pathology similar to those seen in Alzheimer's disease (AD). Long-term treatment with SkQ1 (250 nmol/kg body weight daily from the age of 1.5 to 23 months) reduced the age-related alterations in behavior and spatial memory deficit in Morris water maze in OXYS and Wistar rats. Furthermore, this is the first report that SkQ1 treatment slows down pathological accumulation of AβPP, Aβ, and hyperphosphorylation of tau-protein in OXYS rats, as well as age-dependent changes in healthy Wistar rats. Our results support the possibility of using the OXYS strain as a rat model of AD-like pathology. It seems probable that the mitochondria-targeted antioxidant SkQ1 can be a good prophylactic strategy to maintain brain health and to treat AD.
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AD-related cognitive decline, behavioural test scores and senescence-associated myocardial disease may improve in murine models upon long-term or limited intake of SkQ1.
“Finally, AD-related cognitive decline, behavioural test scores and senescence-associated myocardial disease may improve in murine models upon long-term (lifelong) or limited (between 12 and 18 months of age) intake of SkQ1 [77,78,99,100,101].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [78]
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The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
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- Authors
- Stefanova, N. A., Muraleva, N. A., Skulachev, V. P., & Kolosova, N. G.
- Affiliations
- Institute of Cytology and Genetics (RU)
- Lomonosov Moscow State University (RU)
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2013-11-25
- Volume
- 38
- Issue
- 3
- Pages
- 681-694
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W1643376448
- Cited by
- 80
- References
- 48
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 6 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 6 · 2019: 4 · 2018: 8 · 2017: 8 · 2016: 8 · 2015: 10 · 2014: 11
- FWCI
- 6.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Alzheimer s Disease (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Russian Foundation for Basic Research (11-04-00666)
- Russian Academy of Sciences (11-04-00666)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Keywords
- Alzheimer's disease
- MeSH terms
- Age Factors, Aging, Alzheimer Disease, Animals, Antioxidants, Brain, Cognition Disorders, Disease Models, Animal, Male, Memory Disorders, Mitochondria, Plastoquinone, Rats, Mutant Strains, Space Perception, Rats, Wistar, Maze Learning, Rats
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