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Cited by 242Mitochondrial Function and PathologyAlzheimer's disease research and treatmentsAutophagy in Disease and Therapy

Abnormal Mitochondrial Dynamics in the Pathogenesis of Alzheimer's Disease

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Zhu, Xiongwei, Perry, George, Smith, Mark A., Wang, Xinglong·2012·Journal of Alzheimer's Disease
DOI 10.3233/jad-2012-129005PMC PMC4097015
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Abstract

Mitochondrial dysfunction is one of the most early and prominent features in vulnerable neurons in the brain of Alzheimer's disease (AD) patients. Recent studies suggest that mitochondria are highly dynamic organelles characterized by a delicate balance of fission and fusion, a concept that has revolutionized our basic understanding of the regulation of mitochondrial structure and function which has far-reaching significance in studies of health and disease. Tremendous progress has been made in studying changes in mitochondrial dynamics in AD brain and models and the potential underlying mechanisms. This review highlights the recent work demonstrating abnormal mitochondrial dynamics and distribution in AD models and discusses how these abnormalities may contribute to various aspects of mitochondrial dysfunction and the pathogenesis of AD.

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Authors
Zhu, X., Perry, G., Smith, M. A., & Wang, X.
Affiliations
  • Case Western Reserve University (US)
  • The University of Texas at San Antonio (US)
Corresponding author
Zhu, Xiongwei
ORCID
Venue
Journal of Alzheimer's Disease
Publisher
SAGE Publications
Published
2012-12-27
Volume
33
Issue
s1
Pages
S253-S262
ISSN
  • 1387-2877 (ISSN-L)
  • 1875-8908
DOI
10.3233/jad-2012-129005
PMC
PMC4097015
OpenAlex
W1940759671
Cited by
242
References
16
Citations by year
2026: 13 · 2025: 18 · 2024: 17 · 2023: 15 · 2022: 20 · 2021: 22 · 2020: 19 · 2019: 26 · 2018: 20 · 2017: 19 · 2016: 14 · 2015: 12 · 2014: 10 · 2013: 15 · 2012: 2
FWCI
4.69
Type
journal article
Language
en
Open access
Locations
  • Journal of Alzheimer s Disease (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (R03AG044680, R01AG031852)
  • National Institute on Minority Health and Health Disparities (G12MD007591)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords
Alzheimer's disease, mitochondrial dynamics
MeSH terms
Alzheimer Disease, Animals, Brain, Humans, Mitochondria, Neurons, Mitochondrial Proteins, Mitochondrial Dynamics

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