Cited by 6Tryptophan and brain disordersStress Responses and CortisolNeuroinflammation and Neurodegeneration Mechanisms

Chronic Mild Stress Increases the Expression of Genes Encoding Proinflammatory Cytokines in the Rat Brain

Stepanichev, M. Yu., Peregud, D. I., Manolova, A. O., Lazareva, N. A., Onufriev, M. V., Gulyaeva, N. V.·2018·Biology Bulletin

Abstract

Alterations in the expression of genes encoding interleukins IL-1α, IL-1β, IL-6, and tumor necrosis factor-α (TNF-α) were studied in the rat brain in a model of a depressive disorder. We found that the signs of a depressionlike condition in rats, subjected to eight weeks of chronic mild unpredictable stress, were accompanied by increased IL-1α and IL-1β mRNAs levels in the neocortex, hippocampus, and brainstem and a decreased IL-6 mRNA level in the brainstem as compared to those observed in the control animals. We did not find any changes in the level of TNF-α mRNA. We suggest that region-specific alterations in the expression of cytokine genes, specifically, the most prominent increase in IL-1β expression, reflects greater vulnerability of chronically stressed animals to neuroinflammatory processes.

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Crossref · 10.1134/s1062359018010107

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38 of 38 references verified0 citation errors · 0 not checkable

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  • Increased levels of pro-inflammatory cytokines have been reported in brain regions of stressed animals.

    “and in brain regions of stressed animals [141,142,143].”

    From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [142]

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Authors
Stepanichev, M. Y., Peregud, D. I., Manolova, A. O., Lazareva, N. A., Onufriev, M. V., & Gulyaeva, N. V.
Affiliations
  • Russian Academy of Sciences (RU)
  • Ministry of Health of the Russian Federation (RU)
Corresponding author
Stepanichev, M. Yu.
Venue
Biology Bulletin
Published
2018-03
Volume
45
Issue
2
Pages
186-191
ISSN
  • 1062-3590 (ISSN-L)
  • 1608-3059
OpenAlex
W2801479995
Cited by
6
References
38
Citations by year
2025: 1 · 2024: 1 · 2022: 1 · 2021: 1 · 2019: 2
FWCI
0.23
Type
journal article
Language
en
Open access
closed
Locations
Biology Bulletin (publishedVersion)
Funders
  • Bauman Moscow State Technical University
  • Russian Science Foundation
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
chronic mild stress, depression, inflammatory cytokines, interleukin-1 alpha, IL-1β, interleukin-6, TNF-α, cytokine gene expression, neuroinflammation, hippocampus, neocortex, brainstem, rat model

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