Bone turnover in early rheumatoid arthritis. 1. Biochemical and kinetic indexes.
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Biochemical, hormonal, and kinetic indexes of bone turnover were measured in 17 ambulant female patients with rheumatoid arthritis (RA) of recent onset (mean disease duration 14.2 months) and 19 controls. Mean serum osteocalcin concentration and 85Sr accretion rates were reduced and mean urinary hydroxyproline-creatinine ratios were increased in RA, but these differences were not significant compared with control values. Mean total body potassium (TBK), an index of skeletal muscle mass, was significantly reduced in RA, and the ratio of observed to predicted TBK correlated with indexes of bone formation. No abnormality of skeletal metabolism could be shown in early RA, but reduced rates of bone formation associated with diminished muscle mass may influence the development of osteopenia later in the disease.
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In patients with chronic inflammatory diseases, serum levels of osteocalcin have been described as decreased, increased, or normal.
“In regard to serum levels of osteocalcin, decreased, increased, or normal levels have been described in patients with CIDs [102-106].”
From Interaction of the endocrine system with inflammation: a function of energy and volume regulation (2014) · cites this paper as [102]
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Cited by
Sorted by citations
Interaction of the endocrine system with inflammation: a function of energy and volume regulation
Straub, R. H. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4484 · Cited by 121 · see citing works
Serum osteocalcin concentrations in patients with rheumatoid arthritis.
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- Authors
- Sambrook, P. N., Ansell, B. M., Foster, S., Gumpel, J. M., Hesp, R., Reeve, J., & Zanelli, J. M.
- Affiliations
- Northwick Park Hospital (GB)
- ORCID
- Reeve, J
- Venue
- Annals of the Rheumatic Diseases
- Publisher
- Elsevier BV
- Published
- 1985-09
- Volume
- 44
- Issue
- 9
- Pages
- 575-579
- ISSN
- 0003-4967 (ISSN-L)
- PMC
- PMC1001712
- OpenAlex
- W2110492655
- Cited by
- 43
- References
- 43
- Citations by year
- 2016: 1 · 2015: 1 · 2014: 2 · 2012: 1
- FWCI
- 4.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of the Rheumatic Diseases (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- rheumatoid arthritis, bone turnover, bone formation, osteocalcin, urinary hydroxyproline, total body potassium, skeletal muscle mass, osteopenia, early rheumatoid arthritis
- MeSH terms
- Adult, Aged, Arthritis, Rheumatoid, Bone and Bones, Bone Development, Bone Resorption, Calcitonin, Calcium, Calcium-Binding Proteins, Creatinine, Female, Humans, Hydroxyproline, Middle Aged, Parathyroid Hormone, Potassium, Osteocalcin
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