Quantitative histological data on disuse osteoporosis: Comparison with biological data
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Terrestrial evidence shows that loss of bone matrix and bone mineral due to prolonged bed rest (e.g., disuse medical conditions and/or spinal cord injury) eventually plateaus at 69.0% initial BMD after a period of significant and progressive decline.
“Furthermore, there is terrestrial evidence that the loss of bone matrix and bone mineral due to conditions that result prolonged bed rest (e.g. disuse medical conditions and/or spinal cord injury) eventually plateaus at 69.0% initial BMD, after a period of significant and progressive decline [18,20,21].”
From A human mission to Mars: Predicting the bone mineral density loss of astronauts (2020) · cites this paper as [20]
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Trabecular Bone Microarchitecture Is Deteriorated in Men With Spinal Cord Injury
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Calcium absorption, endogenous excretion, and endocrine changes during and after long-term bed rest
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Altered biochemical markers of bone turnover in humans during 120 days of bed rest
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The effects of immobilization on bone histomorphometry in rats
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A cruciate ligament injury produces considerable, permanent osteoporosis in the affected knee
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Self-citationSimulated microgravity suppresses osteoblast phenotype, Runx2 levels and AP‐1 transactivation
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Self-citation
- Authors
- Minaire, P., Meunier, P., Edouard, C., Bernard, J., Courpron, P., & Bourret, J.
- Affiliations
- Hospices Civils de Lyon (FR)
- ORCID
- Meunier, P.
- Venue
- Calcified Tissue Research
- Published
- 1974-12
- Volume
- 17
- Issue
- 1
- Pages
- 57-73
- ISSN
- 0171-967X (ISSN-L)
- 0008-0594
- 1432-0827
- OpenAlex
- W2908629052
- Cited by
- 435
- References
- 27
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 7 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 11 · 2014: 9 · 2013: 8 · 2012: 5
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Calcified Tissue International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Keywords
- disuse osteoporosis, immobilization, trabecular bone volume, osteoclast resorption, cortical bone thinning, bone turnover, basic multicellular unit, hydroxyprolinuria, urinary calcium excretion, iliac crest bone
- MeSH terms
- Adipose Tissue, Adult, Alkaline Phosphatase, Biopsy, Bone and Bones, Bone Marrow, Bone Marrow Cells, Bone Marrow Examination, Bone Resorption, Calcium, Cell Count, Female, Humans, Hydroxyproline, Ilium, Immobilization, Male, Osteoporosis, Paraplegia, Time Factors
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