Sustained antidepressant response to ketamine
Open accessAbstract
Case series outlining the treatment of three patients with ketamine, in which two of the patients had a sustained antidepressant effect to ketamine without the need for maintenance on antidepressants. These two responders have an established diagnosis of bipolar affective disorder with a history of response to electroconvulsive therapy and lithium, both of which have an influence on the seizure threshold as has ketamine. The mechanism of action of ketamine is yet unclear and although the current focus is on the N-methyl-d-aspartate and alpha-amino-3-4-hydroxy-5methyl-4-isoxazoleproprionic acid receptors, we additionally recommend that its impact on the seizure threshold should be explored with a view to fully elucidating the mechanism of action.
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Janssen is seeking an expansion of esketamine's indications to acutely suicidal patients based on two studies showing a reduction of suicidality on a MADRS subscale at 24 hours but no effect on the pre-specified CGI-SS-R.
“Potentially paradoxically, Janssen is seeking an expansion of the indications for use of esketamine to acutely suicidal patients (on the basis of two studies that showed a reduction of suicidality on a sub-scale of the MADRS at 24 hours, but no effect on the pre-specified measure of suicidality, the CGI-SS-R).27”
From Are we repeating mistakes of the past? A review of the evidence for esketamine (2021) · cites this paper as [27]
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Antidepressant effects of ketamine in depressed patients
Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00230-9 · Cited by 3,856 · see citing works
Burgdorf, J., Zhang, X.-L., Nicholson, K. L., Balster, R. L., David Leander, J., Stanton, P. K., Gross, A. L., Kroes, R. A., & Moskal, J. R. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.246 · Cited by 284 · see citing works
Zarate, C. A., Mathews, D., Ibrahim, L., Chaves, J. F., Marquardt, C., Ukoh, I., Jolkovsky, L., Brutsche, N. E., Smith, M. A., & Luckenbaugh, D. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.10.019 · Cited by 255 · see citing works
Ketamine as a Novel Antidepressant: From Synapse to Behavior
Murrough, J. W. (2012) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2011.244 · Cited by 172 · see citing works
Pro-convulsant effects: A neglected dimension of psychotropic activity
Atigari, O. V., & Healy, D. (2013) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867413495469 · Cited by 5 · see citing works
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Bahji, A., Vazquez, G. H., & Zarate, C. A. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.09.071 · Cited by 408 · see citing works
Are we repeating mistakes of the past? A review of the evidence for esketamine
Horowitz, M. A., & Moncrieff, J. (2021) · The British Journal of Psychiatry · doi:10.1192/bjp.2020.89 · Cited by 53 · see citing works
- Authors
- Atigari, O. V., & Healy, D.
- Affiliations
- Ysbyty Gwynedd Hospital NHS Trust (GB)
- Corresponding author
- Healy, David
- ORCID
- Healy, David
- Venue
- BMJ Case Reports
- Publisher
- BMJ
- Published
- 2013-08-19
- Volume
- 2013
- Pages
- bcr2013200370
- ISSN
- 1757-790X (ISSN-L)
- PMC
- PMC3762430
- OpenAlex
- W2103657566
- Cited by
- 16
- References
- 5
- Citations by year
- 2023: 1 · 2021: 1 · 2020: 3 · 2019: 1 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 1
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BMJ Case Reports (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- ketamine, antidepressant effects, bipolar disorder, seizure threshold, NMDA receptor, AMPA receptors, electroconvulsive therapy, lithium, mechanism of action
- MeSH terms
- Adult, Bipolar Disorder, Major Depressive Disorder, Female, Humans, Ketamine, Middle Aged, Receptors, N-Methyl-D-Aspartate, Treatment Outcome, Excitatory Amino Acid Antagonists
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