Fundus changes in mesangiocapillary glomerulonephritis type II: vitreous fluorophotometry
Open accessAbstract
We have described a complex abnormality of retinal pigment epithelium, Bruch's membrane, and choriocapillaris in mesangiocapillary glomerulonephritis (MCGN) type II. Patients with MCGN type II were examined by vitreous fluorophotometry which reveals that there is a breakdown of the blood retinal barrier (BRB) in those patients with the typical fundus lesions. The function of this barrier was calculated as a penetration ratio and was statistically greater in these patients when compared with a group of (a) normal persons, (b) patients with drusen, and (c) patients with other forms of glomerulonephritis.
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Homozygous deficiency of CFH in humans and mice results in complement factor alternative pathway dysregulation, membranoproliferative glomerulonephritis type II (MPGN2), and an AMD-like phenotype.
“Homozygous deficiency of CFH in humans and mice results in complement factor alternative pathway dysregulation, the inflammatory renal disease membranoproliferative glomerulonephritis type II (MPGN2), and an AMD-like phenotype (Raines et al., 1989; Leys et al., 1991).”
From Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD) (2010) · cites this paper as Raines et al., 1989
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Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD)
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- Authors
- Raines, M. F., Duvall-Young, J., & Short, C. D.
- Affiliations
- Manchester Royal Eye Hospital (GB)
- Venue
- British Journal of Ophthalmology
- Publisher
- BMJ
- Published
- 1989-11-01
- Volume
- 73
- Issue
- 11
- Pages
- 907-910
- ISSN
- 0007-1161 (ISSN-L)
- PMC
- PMC1041924
- OpenAlex
- W2083826326
- Cited by
- 11
- References
- 26
- Citations by year
- 2026: 1 · 2025: 1 · 2021: 1 · 2017: 1
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Ophthalmology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- fundus changes, vitreous fluorophotometry, retinal pigment epithelium, Bruch's membrane, choriocapillaris, blood-retinal barrier breakdown, penetration ratio, drusen, glomerulonephritis
- MeSH terms
- Blood-Retinal Barrier, Choroid, Fluoresceins, Fluorometry, Humans, Lipodystrophy, Photometry, Pigment Epithelium of Eye, Glomerulonephritis, Membranoproliferative
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