Fundus changes in (type II) mesangiocapillary glomerulonephritis simulating drusen: A histopathological report
Open accessAbstract
We report for the first time to our knowledge the histopathological findings in the eye of a patient with type II mesangiocapillary glomerulonephritis (dense deposit disease) in which a deposit of material morphologically very similar to that which is pathognomonic for the disease in the kidney was demonstrated in Bruch's membrane. The nature of the deposit in the renal lesion is unknown but is considered to represent a structural alteration secondary to a reaction with anticomplement antibody. Clinically the fundus appearance resembled that seen in drusen.
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The kidney and eye are known to be susceptible to complement dysregulation.
“and are known to be susceptible to complement dysregulation [7,209].”
From Bruch’s Membrane: A Key Consideration with Complement-Based Therapies for Age-Related Macular Degeneration (2023) · cites this paper as [209]
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Cites
Ocular findings in systemic lupus erythematosus.
Gold, D. H., Morris, D. A., & Henkind, P. (1972) · British Journal of Ophthalmology · doi:10.1136/bjo.56.11.800 · Cited by 207 · see citing works
Berger, M., & Cavanagh, D. (1963) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(63)90528-3 · Cited by 153 · see citing works
Immune-Complex Deposition in the Eye in Systemic Lupus Erythematosus
Aronson, A. J. (1979) · Archives of Internal Medicine · doi:10.1001/archinte.1979.03630480084026 · Cited by 120 · see citing works
Fundus Lesions in Malignant Hypertension
Kishi, S. (1985) · Archives of Ophthalmology · doi:10.1001/archopht.1985.01050080101029 · Cited by 94 · see citing works
Cellular Mechanisms of Resolution of Drusen After Laser Coagulation
Duvall, J. (1985) · Archives of Ophthalmology · doi:10.1001/archopht.1985.01050050086024 · Cited by 92 · see citing works
Choroidal Vascular Changes in Toxemia of Pregnancy
Fastenberg, D. M., Fetkenhour, C. L., Earl, C., et al. (1980) · American Journal of Ophthalmology · doi:10.1016/0002-9394(80)90005-7 · Cited by 89 · see citing works
Ocular Clinical Findings and Basement Membrane Changes in Goodpasture's Syndrome
Jampol, L. M., Lahav, M., Albert, D. M., et al. (1975) · American Journal of Ophthalmology · doi:10.1016/0002-9394(75)90622-4 · Cited by 87 · see citing works
Gitter, K. A. (1968) · Archives of Ophthalmology · doi:10.1001/archopht.1968.00980050451008 · Cited by 68 · see citing works
The eye in malignant hypertension.
Ashton, N. J. (1972) · PubMed · Cited by 68 · see citing works
Ischemic Infarcts of the Choroid (Elschnig Spots)
Klien, B. A. (1968) · American Journal of Ophthalmology · doi:10.1016/0002-9394(68)90815-5 · Cited by 64 · see citing works
EXTENSIVE BILATERAL RETINAL DETACHMENT IN ECLAMPSIA, WITH COMPLETE REATTACHMENT
Fry, W. E. (1929) · Archives of ophthalmology · doi:10.1001/archopht.1929.00810010630010 · Cited by 35 · see citing works
Peress, N. S., Miller, F. W., & Palu, W. (1977) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-197707000-00007 · Cited by 33 · see citing works
Intraocular Pressure Changes During Hemodialysis
Ramsell, J. T., Ellis, P. P., & Paterson, C. A. (1971) · American Journal of Ophthalmology · doi:10.1016/0002-9394(71)91690-4 · Cited by 32 · see citing works
Retinal Separation in Chronic Glomerulonephritis
BUCHANAN, W. S. (1964) · Archives of Ophthalmology · doi:10.1001/archopht.1964.00970010198008 · Cited by 30 · see citing works
Pm, B., Lr, H., & Rp, K. (1973) · PubMed · Cited by 21 · see citing works
Ocular immunopathology in murine lupus.
Pertschuk, L. P., Szabo, K., Vuletin, J. C., et al. (1977) · PubMed · Cited by 19 · see citing works
Corneal crystalline deposits and drusenosis associated with IgA-kappa chain monoclonal gammopathy.
Na, N., Martin, N. F., & Dk, B. (1985) · PubMed · Cited by 10 · see citing works
Post, M. H. (1929) · American Journal of Ophthalmology · doi:10.5555/uri:pii:s0002939429931731 · Cited by 9 · see citing works
Retinopathies of Chronic Glomerulonephritis
Ellis, P. P. (1966) · Archives of Ophthalmology · doi:10.1001/archopht.1966.00970050038008 · Cited by 5 · see citing works
Central Retinal Vein Occlusion Following Peritoneal Dialysis
Pratt, M. V., & de Venecia, G. (1970) · American Journal of Ophthalmology · doi:10.1016/0002-9394(70)90092-9 · Cited by 4 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Burkholder PM, Hyman CR, Kryer RP. Characterisation of mixed membranous and proliferative glomerulonephritis. In: Kincaid-Smith P, Matthew TH, Becker EL, eds. Glomerulonephritis. New York: J Wiley, 1973: 557.
- Klein BA. Ischaemic infarcts of the choroid. Am J Ophthalmol 1969; 66: 1069-74.
- Ellis PP, Fonkin HA. Retinopathies of chronic glomerulone- phritis. Arch Ophthalmol 1966; 75: 36-41.
Cited by
Sorted by citations
Hageman, G. (2001) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(01)00010-6 · Cited by 1,265 · see citing works
Mullins, R. F., Russell, S. R., Anderson, D. H., & Hageman, G. S. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.7.835 · Cited by 937 · see citing works
Animal models of age related macular degeneration
Pennesi, M. E., Neuringer, M., & Courtney, R. J. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.06.003 · Cited by 391 · see citing works
Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction
Coffey, P. J., Gias, C., McDermott, C. J., Lundh, P., Pickering, M. C., Sethi, C., Bird, A., Fitzke, F. W., Maass, A., Chen, L. L., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705079104 · Cited by 231 · see citing works
Mullins, R. F., Aptsiauri, N., & Hageman, G. S. (2001) · Eye · doi:10.1038/eye.2001.142 · Cited by 231 · see citing works
On the origin of proteins in human drusen: The meet, greet and stick hypothesis
Bergen, A. A., Arya, S., Koster, C., Pilgrim, M. G., Wiatrek-Moumoulidis, D., van der Spek, P. J., Hauck, S. M., Boon, C. J. F., Emri, E., Stewart, A. J., et al. (2019) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2018.12.003 · Cited by 101 · see citing works
Leys, A., Vanrenterghem, Y., Van Damme, B., Snyers, B., Pirson, Y., & Leys, M. (1991) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/bf00166300 · Cited by 57 · see citing works
Hammadi, S., Tzoumas, N., Ferrara, M., Meschede, I. P., Lo, K., Harris, C., Lako, M., & Steel, D. H. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12082870 · Cited by 44 · see citing works
Complement inhibitors for age-related macular degeneration
Tzoumas, N., Riding, G., Williams, M. A., & Steel, D. H. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009300.pub3 · Cited by 38 · see citing works
Tzoumas, N., Hallam, D., Harris, C. L., Lako, M., Kavanagh, D., & Steel, D. H. W. (2021) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2020.10.008 · Cited by 33 · see citing works
Fundus changes in mesangiocapillary glomerulonephritis type II: vitreous fluorophotometry
Raines, M. F., Duvall-Young, J., & Short, C. D. (1989) · British Journal of Ophthalmology · doi:10.1136/bjo.73.11.907 · Cited by 11 · see citing works
Self-citation
- Authors
- Duvall-Young, J., MacDonald, M. K., & McKechnie, N. M.
- Affiliations
- Princess Alexandra Eye Pavilion (GB)
- Venue
- British Journal of Ophthalmology
- Publisher
- BMJ
- Published
- 1989-04-01
- Volume
- 73
- Issue
- 4
- Pages
- 297-302
- ISSN
- 0007-1161 (ISSN-L)
- PMC
- PMC1041718
- OpenAlex
- W1998406682
- Cited by
- 124
- References
- 21
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 6 · 2017: 4 · 2016: 7 · 2015: 3 · 2014: 4 · 2013: 6 · 2012: 6
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Ophthalmology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- University of Glasgow
- Topics
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Keywords
- dense deposit disease, fundus changes, drusen, Bruch's membrane, histopathology, fundus appearance
- MeSH terms
- Adolescent, Basement Membrane, Choroid, Fluorescein Angiography, Humans, Male, Glomerulonephritis, Membranoproliferative
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