The DOI matches its Crossref record; 244 of the 244 references it cites were found in a registry or an index.
Antiphospholipid syndrome: advances in diagnosis, pathogenesis, and management
Abstract
Antiphospholipid syndrome (APS) is a thrombo-inflammatory disease propelled by circulating autoantibodies that recognize cell surface phospholipids and phospholipid binding proteins. The result is an increased risk of thrombotic events, pregnancy morbidity, and various other autoimmune and inflammatory complications. Although antiphospholipid syndrome was first recognized in patients with lupus, the stand alone presentation of antiphospholipid syndrome is at least equally common. Overall, the diagnosis appears to affect at least one in 2000 people. Studies of antiphospholipid syndrome pathogenesis have long focused on logical candidates such as coagulation factors, endothelial cells, and platelets. Recent work has shed light on additional potential therapeutic targets within the innate immune system, including the complement system and neutrophil extracellular traps. Vitamin K antagonists remain the mainstay of treatment for most patients with thrombotic antiphospholipid syndrome and, based on current data, appear superior to the more targeted direct oral anticoagulants. The potential role of immunomodulatory treatments in antiphospholipid syndrome management is receiving increased attention. As for many systemic autoimmune diseases, the most important future direction is to more precisely identify mechanistic drivers of disease heterogeneity in pursuit of unlocking personalized and proactive treatments for patients.
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Cites
Neutrophil Extracellular Traps Kill Bacteria
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Self-citationCoagulopathy and Antiphospholipid Antibodies in Patients with Covid-19
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Terminal Complement Inhibitor Eculizumab in Atypical Hemolytic–Uremic Syndrome
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The management of thrombosis in the antiphospholipid-antibody syndrome
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EULAR recommendations for the management of antiphospholipid syndrome in adults
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“Such an approach can be supported by a systematic review that found only seven of 180 recurrent thrombotic events occurred in patients when the INR was >3.0, 203 while noting that recent EULAR guidelines did not reach a consensus on this topic.”
BackgroundMethodInfluentialUpdate of the guidelines for lupus anticoagulant detection
PENGO, V., TRIPODI, A., REBER, G., RAND, J. H., ORTEL, T. L., GALLI, M., & DE GROOT, P. G. (2009) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2009.03555.x · Cited by 1,197
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Cited by
Lupus Anticoagulant Testing in Challenging Situations: Navigating Complexities
Devreese, K. M. J. (2026) · International Journal of Laboratory Hematology · doi:10.1111/ijlh.14490 · Cited by 2
Metadata
- Authors
- Knight, J. S., Branch, D. W., & Ortel, T. L.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2023-02-27
- Volume
- 380
- Pages
- e069717
- ISSN
- 1756-1833 (ISSN-L)
- OpenAlex
- W4322494788
- Cited by
- 265
- References
- 244
- FWCI
- 46.05
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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