Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19
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The authors describe a 69-year-old man with Covid-19 diagnosed in January 2020 in Wuhan, China, along with two other critically ill patients with Covid-19 who were also seen in the same intensive care unit. Coagulopathy and antiphospholipid antibodies were seen in all three patients.
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Many neurological symptoms associated with CoV-2 infection, such as stroke or altered consciousness, are consistent with underlying vasculopathy.
“Multiple immunostaining studies reveal that ACE2 protein in the human brain is predominantly or exclusively expressed in vasculature (and specifically expressed within pericytes) (52, 53, 70), and many neurological symptoms associated with CoV-2 infection like stroke or altered consciousness are consistent with an underlying vasculopathy (71-76).”
From Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia (2020) · cites this paper as [71]
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- Authors
- Zhang, Y., Xiao, M., Zhang, S., Xia, P., Cao, W., Jiang, W., Chen, H., Ding, X., Zhao, H., Zhang, H., Wang, C., Zhao, J., Sun, X., Tian, R., Wu, W., Wu, D., Ma, J., Chen, Y., Zhang, D., Xie, J., Yan, X., Zhou, X., Liu, Z., Wang, J., Du, B., Qin, Y., Gao, P., Qin, X., Xu, Y., Zhang, W., Li, T., Zhang, F., Zhao, Y., Li, Y., & Zhang, S.
- Affiliations
- Peking Union Medical College Hospital (CN)
- Peking Union Medical College Hospital, Beijing, China
- ORCID
- Zhang, Yan
- Xiao, Meng
- Zhang, Shulan
- Cao, Wei
- Jiang, Wei
- Chen, Huan
- Ding, Xin
- Zhao, Hua
- Zhang, Hongmin
- Wang, Chunyao
- Zhao, Jing
- Wu, Wei
- Wu, Dong
- Ma, Jie
- Zhang, Dong
- Xie, Jing
- Yan, Xiaowei
- Zhou, Xiang
- Du, Bin
- Qin, Yan
- Gao, Peng
- Qin, Xuzhen
- Xu, Yingchun
- Zhang, Wen
- Li, Taisheng
- Zhang, Fengchun
- Zhao, Yongqiang
- Li, Yongzhe
- Zhang, Shuyang
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2020-04-23
- Volume
- 382
- Issue
- 17
- Pages
- e38-e38
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC7161262
- OpenAlex
- W3014573995
- Cited by
- 2,179
- References
- 1
- Citations by year
- 2026: 17 · 2025: 37 · 2024: 88 · 2023: 143 · 2022: 280 · 2021: 630 · 2020: 973 · 2019: 3 · 2018: 2 · 2012: 1
- FWCI
- 66.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Surgery › Heparin-Induced Thrombocytopenia and Thrombosis
- Keywords
- COVID-19 pandemic, coagulopathy, antiphospholipid antibodies, critically ill patients, intensive care unit, thrombosis, hypercoagulability
- MeSH terms
- COVID-19, Aged, Antibodies, Anti-Idiotypic, Blood Coagulation Disorders, Humans, Immunoglobulin A, Immunoglobulin G, Male, Pneumonia, Viral, Antibodies, Antiphospholipid, Antibodies, Anticardiolipin, Coronavirus Infections, Pandemics
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