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Cited by 46Respiratory viral infections researchHerbal Medicine Research StudiesPediatric health and respiratory diseases

Effects of pseudoephedrine and triprolidine, alone and in combination, on symptoms of the common cold

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Bye, C E, Cooper, J, Empey, D W, Fowle, A S, Hughes, D T, Letley, E, O'Grady, J·1980·BMJ
DOI 10.1136/bmj.281.6234.189
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Abstract

A total of 466 healthy adults from four different regions of England entered a double-blind, randomised trial to test the effectiveness of an antihistamine (triprolidine) and a decongestant (pseudoephedrine), alone or in combination, in relieving symptoms of the common cold. During the study 199 subjects reported a total of 243 colds. Subjects recorded the severity of 12 symptoms during treatment and noted separately the severity of a further seven symptoms that represented unwanted effects of treatment or served as an index of suggestibility. They were then asked about their overall improvement in symptoms during treatment and whether they thought they had taken placebo. Sneezing, nasal obstruction, and overall response to treatment were significantly improved (p <0.01) with psuedoephedrine or pseudoephedrine and triprolidine compared with placebo.

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  • In Bye 1980, sneezing severity scores were significantly lower with active treatment on days two, three, and four.

    “In Bye 1980, severity scores for sneezing were significantly lower with active treatment on days two, three, and four (no P values mentioned).”

    From Oral antihistamine-decongestant-analgesic combinations for the common cold (2022) · cites this paper as Bye 1980

    The Results report significantly reduced sneezing scores on days 2, 3, and 4 for the pseudoephedrine–triprolidine combination versus placebo. The unqualified phrase “active treatment” is broader than that finding: pseudoephedrine alone was significant only on days 2 and 3, and triprolidine alone only on day 2. No page number is supplied for the passage. (LLM, conf=0.85)

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  • In Berkowitz 1989 and Bye 1980, no significant difference in severity of cough was found between active treatment and control.

    “Neither Berkowitz 1989 nor Bye 1980 found any significant difference in severity of cough between the active treatment group and the control group.”

    From Oral antihistamine-decongestant-analgesic combinations for the common cold (2022) · cites this paper as Bye 1980

  • In Bye 1980, no effect of active treatment on rhinorrhoea was noted.

    “In Bye 1980, no effect of active treatment was noted.”

    From Oral antihistamine-decongestant-analgesic combinations for the common cold (2022) · cites this paper as Bye 1980

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Research works printed but not linked: 1

  1. Reference Medical Research Council Special Committee. Clinical trials of anti- histaminic drugs in the prevention and treatment of the common cold. Br MedJ7 1950;ii:425-9. (Accepted 14 May 1980) on 26 October 2023 by guest. Protected by copyright. http://www.bmj.com/ Br Med J: first published as 10.1136/bmj.281.6234.189 on 19 July 1980. Downloaded from

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Authors
Bye, C. E., Cooper, J., Empey, D. W., Fowle, A. S., Hughes, D. T., Letley, E., & O'Grady, J.
Affiliations
Royal London Hospital (GB)
ORCID
Cooper, J
Venue
BMJ
Publisher
BMJ
Published
1980-07-19
Volume
281
Issue
6234
Pages
189-190
ISSN
  • 0007-1447 (ISSN-L)
  • 1468-5833
DOI
10.1136/bmj.281.6234.189
OpenAlex
W2051205870
Cited by
46
References
0
Citations by year
2026: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2016: 2 · 2015: 1 · 2012: 1
FWCI
4.21
Type
journal article
Language
en
Open access
Licence
www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy (tdm)
Locations
  • BMJ (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
  • Health Sciences › Medicine › Complementary and alternative medicine › Herbal Medicine Research Studies
  • Health Sciences › Health Professions › Emergency Medical Services › Pediatric health and respiratory diseases
Keywords
common cold, pseudoephedrine, triprolidine, antihistamines, decongestants, nasal obstruction, sneezing, placebo response, adverse drug reactions, combination therapy
MeSH terms
Clinical Trials as Topic, Common Cold, Double-Blind Method, Drug Combinations, Ephedrine, Humans, Pyridines, Random Allocation, Triprolidine

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