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Intestinal permeability in children with Crohn's disease and coeliac disease.
Open accessAbstract
Mannitol and lactulose were used as probe molecules to measure intestinal permeability in children with active small-bowel Crohn's disease and with untreated coeliac disease. Mannitol and lactulose were administered by mouth in a moderately hypertonic solution (580 mmol (mosmol)/l), and results were expressed as the ratio of the molecules excreted in urine over five hours. Patients with Crohn's disease had a sixfold increase in permeability (due to increased lactulose permeability) and those with coeliac disease a fivefold increase (due to decreased mannitol permeability). From these results the test offers potential as a noninvasive investigation in children with small-bowel disease.
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Citations
Cited by
Intestinal mucosal barrier function in health and disease
Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952
The intestinal epithelial barrier: a therapeutic target?
Odenwald, M. A., & Turner, J. R. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.169 · Cited by 1,288
Spiller, R. C., Jenkins, D., Thornley, J. P., Hebden, J. M., Wright, T., Skinner, M., & Neal, K. R. (2000) · Gut · doi:10.1136/gut.47.6.804 · Cited by 1,155
HOLLANDER, D., VADHEIM, C. M., BRETTHOLZ, E., PETERSEN, G. M., DELAHUNTY, T., & ROTTER, J. I. (1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-105-6-883 · Cited by 760
Su, L., Shen, L., Clayburgh, D. R., Nalle, S. C., Sullivan, E. A., Meddings, J. B., Abraham, C., & Turner, J. R. (2009) · Gastroenterology · doi:10.1053/j.gastro.2008.10.081 · Cited by 455
Metadata
- Authors
- Pearson, A. D., Eastham, E. J., Laker, M. F., Craft, A. W., & Nelson, R.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1982-07-03
- Volume
- 285
- Issue
- 6334
- Pages
- 20-21
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- OpenAlex
- W2064048008
- Cited by
- 225
- References
- 0
- FWCI
- 7.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Pearson, A. D., Eastham, E. J., Laker, M. F., Craft, A. W., & Nelson, R. (1982). Intestinal permeability in children with Crohn's disease and coeliac disease. BMJ. https://doi.org/10.1136/bmj.285.6334.20
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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