The intestinal epithelial barrier: a therapeutic target?

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) · Nature · doi:10.1038/nature07935 · Cited by 7,204 · see citing works

Interleukin-10-deficient mice develop chronic enterocolitis

Kühn, R., Löhler, J., Rennick, D. M., Rajewsky, K., & Müller, W. (1993) · Cell · doi:10.1016/0092-8674(93)80068-p · Cited by 4,248 · see citing works

Intestinal mucosal barrier function in health and disease

Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952 · see citing works

JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA

Farquhar, M. G., & Palade, G. E. (1963) · The Journal of Cell Biology · doi:10.1083/jcb.17.2.375 · Cited by 3,637 · see citing works

Robbins and Cotran Pathologic Basis of Disease

Hoda, S. A., & Hoda, R. S. (2020) · American Journal of Clinical Pathology · doi:10.1093/ajcp/aqaa163 · Cited by 3,369 · see citing works

Occludin: a novel integral membrane protein localizing at tight junctions.

Furuse, M., Hirase, T., Itoh, M., Nagafuchi, A., Yonemura, S., Tsukita, S., & Tsukita, S. (1993) · The Journal of cell biology · doi:10.1083/jcb.123.6.1777 · Cited by 2,580 · see citing works

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

Johansson, M. E. V., Phillipson, M., Petersson, J., Velcich, A., Holm, L., & Hansson, G. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803124105 · Cited by 2,200 · see citing works

Crypt stem cells as the cells-of-origin of intestinal cancer

Barker, N., Ridgway, R. A., van Es, J. H., van de Wetering, M., Begthel, H., van den Born, M., Danenberg, E., Clarke, A. R., Sansom, O. J., & Clevers, H. C. (2008) · Nature · doi:10.1038/nature07602 · Cited by 2,159 · see citing works

Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells

Snippert, H. J., van der Flier, L. G., Sato, T., van Es, J. H., van den Born, M., Kroon-Veenboer, C., Barker, N., Klein, A. M., van Rheenen, J., Simons, B. D., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.016 · Cited by 1,951 · see citing works

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

Wen, L., Ley, R. E., Volchkov, P. Y., Stranges, P. B., Avanesyan, L., Stonebraker, A. C., Hu, C., Wong, F. S., Szot, G. L., Bluestone, J. A., et al. (2008) · Nature · doi:10.1038/nature07336 · Cited by 1,921 · see citing works

Stem cells, self-renewal, and differentiation in the intestinal epithelium.

van der Flier, L. G., & Clevers, H. (2009) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163145 · Cited by 1,859 · see citing works

The Microbiome in Inflammatory Bowel Disease: Current Status and the Future Ahead

Kostic, A. D., Xavier, R. J., & Gevers, D. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.02.009 · Cited by 1,789 · see citing works

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

The Type 1 Diabetes Genetics Consortium, Barrett, J. C., Clayton, D. G., Concannon, P., Akolkar, B., Cooper, J. D., Erlich, H. A., Julier, C., Morahan, G., Nerup, J., et al. (2009) · Nature Genetics · doi:10.1038/ng.381 · Cited by 1,746 · see citing works

Muc2-Deficient Mice Spontaneously Develop Colitis, Indicating That MUC2 Is Critical for Colonic Protection

Van der Sluis, M., De Koning, B. A. E., De Bruijn, A. C. J. M., Velcich, A., Meijerink, J. P. P., Van Goudoever, J. B., Büller, H. A., Dekker, J., Van Seuningen, I., Renes, I. B., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.04.020 · Cited by 1,684 · see citing works

Robbins and Cotran Pathologic Basis of Disease

Hoda, S. A., & Hoda, R. S. (2005) · Advances in Anatomic Pathology · doi:10.1097/01.pap.0000155072.86944.7d · Cited by 1,578 · see citing works

Adherens and tight junctions: Structure, function and connections to the actin cytoskeleton

Hartsock, A., & Nelson, W. J. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.07.012 · Cited by 1,559 · see citing works

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

Glocker, E., Kotlarz, D., Boztuǧ, K., Gertz, E. M., Schäffer, A. A., Noyan, F., Perro, M., Diestelhorst, J., Saborowski, A. L., Murugan, D., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0907206 · Cited by 1,464 · see citing works

Interleukin-13 Is the Key Effector Th2 Cytokine in Ulcerative Colitis That Affects Epithelial Tight Junctions, Apoptosis, and Cell Restitution

Heller, F., Florian, P., Bojarski, C., Richter, J. F., Christ, M., Hillenbrand, B., Mankertz, J., Gitter, A. H., Bürgel, N., Fromm, M., et al. (2005) · Gastroenterology · doi:10.1016/j.gastro.2005.05.002 · Cited by 1,237 · see citing works

Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease

Zeißig, S., Bürgel, N., Günzel, D., Richter, J. F., Mankertz, J., Wahnschaffe, U., Kroesen, A. J., Zeitz, M., Fromm, M., & Schulzke, J. (2006) · Gut · doi:10.1136/gut.2006.094375 · Cited by 1,218 · see citing works

Complex Phenotype of Mice Lacking Occludin, a Component of Tight Junction Strands

Saitou, M., Furuse, M., Sasaki, H., Schulzke, J.-D., Fromm, M., Takano, H., Noda, T., & Tsukita, S. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.12.4131 · Cited by 1,195 · see citing works

CLAUDINS AND EPITHELIAL PARACELLULAR TRANSPORT

Itallie, C. M. V., & Anderson, J. M. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040104.131404 · Cited by 1,123 · see citing works

Lineage Tracing Reveals Lgr5 + Stem Cell Activity in Mouse Intestinal Adenomas

Schepers, A. G., Snippert, H. J. G., Stange, D. E., van den Born, M., van Es, J. H., van de Wetering, M., & Clevers, H. C. (2012) · Science · doi:10.1126/science.1224676 · Cited by 1,072 · see citing works

Glucosylation of Rho proteins by Clostridium difficile toxin B

Just, I., Selzer, J., Wilm, M. S., von Eichel-Streiber, C., Mann, M., & Aktories, K. (1995) · Nature · doi:10.1038/375500a0 · Cited by 1,032 · see citing works

Interleukin-13 Is the Key Effector Th2 Cytokine in Ulcerative Colitis That Affects Epithelial Tight Junctions, Apoptosis, and Cell Restitution

Heller, F., Florian, P., Bojarski, C., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.05.002 · Cited by 1,016 · see citing works

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

Johansson, M. E. V., Gustafsson, J. K., Holmén-Larsson, J., Jabbar, K. S., Xia, L., Xu, H., Ghishan, F. K., Carvalho, F. A., Gewirtz, A. T., Sjövall, H., et al. (2014) · Gut · doi:10.1136/gutjnl-2012-303207 · Cited by 1,004 · see citing works

α-Catenin Is a Molecular Switch that Binds E-Cadherin-β-Catenin and Regulates Actin-Filament Assembly

Drees, F., Pokutta, S., Yamada, S., Nelson, W. J., & Weis, W. I. (2005) · Cell · doi:10.1016/j.cell.2005.09.021 · Cited by 986 · see citing works

Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions.

Furuse, M., Itoh, M., Hirase, T., Nagafuchi, A., Yonemura, S., Tsukita, S., & Tsukita, S. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.6.1617 · Cited by 965 · see citing works

Intestinal permeability: an overview

Bjarnason, I., Macpherson, A., & Hollander, D. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90708-4 · Cited by 927 · see citing works

Tight Junction Pore and Leak Pathways: A Dynamic Duo

Shen, L., Weber, C. R., Raleigh, D. R., Yu, D., & Turner, J. R. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-012110-142150 · Cited by 867 · see citing works

Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells

Amasheh, S., Meiri, N., Gitter, A. H., Schöneberg, T., Mankertz, J., Schulzke, J. D., & Fromm, M. (2002) · Journal of Cell Science · doi:10.1242/jcs.00165 · Cited by 812 · see citing works

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell

Yui, S., Nakamura, T., Sato, T., Nemoto, Y., Mizutani, T., Zheng, X., Ichinose, S., Nagaishi, T., Okamoto, R., Tsuchiya, K., et al. (2012) · Nature Medicine · doi:10.1038/nm.2695 · Cited by 805 · see citing works

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migrationPreprint

Sansom, O. J., Reed, K. R., Hayes, A. J., Ireland, H., Brinkmann, H., Newton, I. P., Batlle, E., Simon-Assmann, P. M., Clevers, H. C., Näthke, I. S., et al. (2004) · Genes & Development · doi:10.1101/gad.287404 · Cited by 799 · see citing works

Increased Intestinal Permeability in Patients with Crohn's Disease and Their Relatives

Hollander, D., Vadheim, C. M., Brettholz, E., Petersen, G. M., Delahunty, T., & Rotter, J. I. (1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-105-6-883 · Cited by 762 · see citing works

Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease

Tibble, J. A., Sigthorsson, G., Bridger, S., Fagerhol, M. K., & Bjarnason, I. (2000) · Gastroenterology · doi:10.1053/gast.2000.8523 · Cited by 759 · see citing works

Conversion of Zonulae Occludentes from Tight to Leaky Strand Type by Introducing Claudin-2 into Madin-Darby Canine Kidney I Cells

Furuse, M., Furuse, K., Sasaki, H., & Tsukita, S. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.2.263 · Cited by 719 · see citing works

Experimental Models of Inflammatory Bowel Diseases

Kiesler, P., Fuss, I. J., & Strober, W. (2015) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2015.01.006 · Cited by 719 · see citing works

The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor

Powell, A. E., Wang, Y., Li, Y., Poulin, E. J., Means, A. L., Washington, M. K., Higginbotham, J. N., Juchheim, A., Prasad, N., Levy, S. E., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.042 · Cited by 694 · see citing works

Interferon-γ and Tumor Necrosis Factor-α Synergize to Induce Intestinal Epithelial Barrier Dysfunction by Up-Regulating Myosin Light Chain Kinase Expression

Wang, F., Graham, W. V., Wang, Y., Witkowski, E. D., Schwarz, B. T., & Turner, J. R. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62264-x · Cited by 692 · see citing works

Inflammatory Bowel Disease and Adenomas in Mice Expressing a Dominant Negative N-Cadherin

Hermiston, M. L., & Gordon, J. I. (1995) · Science · doi:10.1126/science.270.5239.1203 · Cited by 669 · see citing works

Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease

Fasano, A., Not, T., Wang, W., Uzzau, S., Berti, I., Tommasini, A., & Goldblum, S. E. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02169-3 · Cited by 668 · see citing works

Intestinal permeability and the prediction of relapse in Crohn's disease

Wyatt, J., Vogelsang, H., Hübl, W., Waldhoer, T., & Lochs, H. (1993) · The Lancet · doi:10.1016/0140-6736(93)90882-h · Cited by 626 · see citing works

A FINE STRUCTURAL ANALYSIS OF INTERCELLULAR JUNCTIONS IN THE MOUSE LIVER

Goodenough, D. A., & Revel, J. P. (1970) · The Journal of Cell Biology · doi:10.1083/jcb.45.2.272 · Cited by 625 · see citing works

Clostridium perfringens Enterotoxin Fragment Removes Specific Claudins from Tight Junction Strands

Sonoda, N., Furuse, M., Sasaki, H., Yonemura, S., Katahira, J., Horiguchi, Y., & Tsukita, S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.1.195 · Cited by 612 · see citing works

Epithelial Barriers in Homeostasis and Disease

Marchiando, A. M., Graham, W. V., & Turner, J. R. (2010) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092135 · Cited by 612 · see citing works

Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis

Schmitz*, H., Barmeyer, C., Fromm, M., Runkel§, N., Foss, H., Bentzel, C. J., Riecken, E., & Schulzke, J.-D. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70126-5 · Cited by 607 · see citing works

Dynamic contacts: rearranging adherens junctions to drive epithelial remodelling

Takeichi, M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3802 · Cited by 605 · see citing works

An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanism

Rosenblatt, J., RAFF, M. C., & Cramer, L. P. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00587-5 · Cited by 602 · see citing works

Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region

Barrett, J., Lee, J. C., Lees, C., Prescott, N., Anderson, C., Phillips, A., Wesley, E., Parnell, K. S., Zhang, H., Drummond, H., et al. (2009) · Nature Genetics · doi:10.1038/ng.483 · Cited by 602 · see citing works

Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation

Turner, J. R., Rill, B. K., Carlson, S. L., Carnes, D., Kerner, R., Mrsny, R. J., & Madara, J. (1997) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1997.273.4.c1378 · Cited by 553 · see citing works

Zonulin Upregulation Is Associated With Increased Gut Permeability in Subjects With Type 1 Diabetes and Their Relatives

Sapone, A., de Magistris, L., Pietzak, M. M., Clemente, M. G., Tripathi, A. K., Cucca, F., Lampis, R., Kryszak, D., Cartenı̀, M., Generoso, M., et al. (2006) · Diabetes · doi:10.2337/db05-1593 · Cited by 550 · see citing works

Interleukin-6 (IL-6) Regulates Claudin-2 Expression and Tight Junction Permeability in Intestinal Epithelium

Suzuki, T., Yoshinaga, N., & Tanabe, S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.238147 · Cited by 527 · see citing works

Contribution of solvent drag through intercellular junctions to absorption of nutrients by the small intestine of the rat

Pappenheimer, J. R., & Reiss, K. Z. (1987) · The Journal of Membrane Biology · doi:10.1007/bf02209145 · Cited by 527 · see citing works

Structural basis for physiological regulation of paracellular pathways in intestinal epithelia

Madara, J., & Pappenheimer, J. R. (1987) · The Journal of Membrane Biology · doi:10.1007/bf02209147 · Cited by 522 · see citing works

Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells

Prasad, S. B., Mingrino, R., Kaukinen, K., Hayes, K. L., Powell, R. M., MacDonald, T. T., & Collins, J. E. (2005) · Laboratory Investigation · doi:10.1038/labinvest.3700316 · Cited by 493 · see citing works

ZO-1 Stabilizes the Tight Junction Solute Barrier through Coupling to the Perijunctional Cytoskeleton

Itallie, C. M. V., Fanning, A. S., Bridges, A. S., & Anderson, J. M. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-04-0320 · Cited by 479 · see citing works

Caveolin-1–dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo

Marchiando, A. M., Shen, L., Graham, W. V., Weber, C. R., Schwarz, B. T., Austin, J. R., Raleigh, D. R., Guan, Y., Watson, A. J. M., Montrose, M. H., et al. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200902153 · Cited by 475 · see citing works

Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure

Shen, L., Black, E. D., Witkowski, E. D., Lencer, W. I., Guerriero, V., Schneeberger, E. E., & Turner, J. R. (2006) · Journal of Cell Science · doi:10.1242/jcs.02915 · Cited by 467 · see citing works

Tumor necrosis factor α antibody (infliximab) therapy profoundly down-regulates the inflammation in Crohn's ileocolitis

Baert, F. J., D’Haens, G., Peeters, M., Hiele, M. I., Schaible, T. F., Shealy, D. J., Geboes, K. J., & Rutgeerts, P. J. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70224-6 · Cited by 460 · see citing works

Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis

Su, L., Shen, L., Clayburgh, D. R., Nalle, S. C., Sullivan, E. A., Meddings, J. B., Abraham, C., & Turner, J. R. (2009) · Gastroenterology · doi:10.1053/j.gastro.2008.10.081 · Cited by 455 · see citing works

A Controlled Trial of Gluten-Free Diet in Patients With Irritable Bowel Syndrome-Diarrhea: Effects on Bowel Frequency and Intestinal Function

Vázquez‐Roque, M. I., Camilleri, M., Smyrk, T. C., Murray, J. A., Marietta, E. V., O’Neill, J., Carlson, P., Lamsam, J. L., Janzow, D., Eckert, D. J., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.01.049 · Cited by 454 · see citing works

Increased intestinal permeability precedes clinical onset of type 1 diabetes

Bosi, E., Molteni, L., Radaelli, M. G., Folini, L., Fermo, I., Bazzigaluppi, E., Piemonti, L., Pastore, M. R., & Paroni, R. C. (2006) · Diabetologia · doi:10.1007/s00125-006-0465-3 · Cited by 444 · see citing works

Graft-versus-Host Disease and Survival in Patients with Aplastic Anemia Treated by Marrow Grafts from HLA-Identical Siblings

Storb, R. F., Prentice, R. L., Buckner, C. D., Clift, R. A., Appelbaum, F. R., Deeg, J., Doney, K., Hansen, J. A., Mason, M. W., Sanders, J. E., et al. (1983) · New England Journal of Medicine · doi:10.1056/nejm198302103080602 · Cited by 431 · see citing works

Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo

Clayburgh, D. R. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24970 · Cited by 419 · see citing works

Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function

Clemente, M. G. (2003) · Gut · doi:10.1136/gut.52.2.218 · Cited by 415 · see citing works

Loss of the Tight Junction Protein ZO-1 in Dextran Sulfate Sodium Induced Colitis

Poritz, L. S., Garver, K. I., Green, C., Fitzpatrick, L. R., Ruggiero, F. M., & Koltun, W. A. (2007) · Journal of Surgical Research · doi:10.1016/j.jss.2006.07.050 · Cited by 414 · see citing works

Temporal and Spatial Analysis of Clinical and Molecular Parameters in Dextran Sodium Sulfate Induced Colitis

Yan, Y., Kolachala, V. L., Dalmasso, G., Nguyen, H. T. T., Laroui, H., Sitaraman, S. V., & Merlin, D. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006073 · Cited by 412 · see citing works

Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling

Wong, V. W. Y., Stange, D. E., Page, M. E., Buczacki, S. J. A., Wabik, A., Itami, S., van de Wetering, M., Poulsom, R., Wright, N. A., Trotter, M. W. B., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2464 · Cited by 409 · see citing works

TH9 cells that express the transcription factor PU.1 drive T cell–mediated colitis via IL-9 receptor signaling in intestinal epithelial cells

Gerlach, K., Hwang, Y., Nikolaev, A., Atreya, R., Dornhoff, H., Steiner, S., Lehr, H.-A., Wirtz, S., Vieth, M., Waisman, A., et al. (2014) · Nature Immunology · doi:10.1038/ni.2920 · Cited by 407 · see citing works

Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease

Suenaert, P., Bulteel, V., Lemmens, L., Noman, M., Geypens, B. J., Assche, G. V., Geboes, K. J., Ceuppens, J. L., & Rutgeerts, P. J. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05914.x · Cited by 402 · see citing works

Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease

Kießlich, R., Duckworth, C. A., Moussata, D., Gloeckner, A., Lim, L. G., Goetz, M., Pritchard, D. M., Galle, P. R., Neurath, M. F., & Watson, A. J. M. (2011) · Gut · doi:10.1136/gutjnl-2011-300695 · Cited by 394 · see citing works

TNFR2 Activates MLCK-Dependent Tight Junction Dysregulation to Cause Apoptosis-Mediated Barrier Loss and Experimental Colitis

Su, L., Nalle, S. C., Shen, L., Turner, E. S., Singh, G., Breskin, L. A., Khramtsova, E. A., Khramtsova, G. F., Tsai, P., Fu, Y., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.04.011 · Cited by 393 · see citing works

Zonula Occludens‐1 and ‐2 Are Cytosolic Scaffolds That Regulate the Assembly of Cellular Junctions

Fanning, A. S., & Anderson, J. M. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04440.x · Cited by 392 · see citing works

A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease

Zolotarevsky, Y., Hecht, G. A., Koutsouris, A., Gonzalez, D. E., Quan, C., Tom, J., Mrsny, R. J., & Turner, J. R. (2002) · Gastroenterology · doi:10.1053/gast.2002.34235 · Cited by 385 · see citing works

Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation

Weber, C. R., Nalle, S. C., Tretiakova, M., Rubin, D. T., & Turner, J. R. (2008) · Laboratory Investigation · doi:10.1038/labinvest.2008.78 · Cited by 370 · see citing works

Intestinal Permeability Defects: Is It Time to Treat?

Odenwald, M. A., & Turner, J. R. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.07.001 · Cited by 366 · see citing works

Loss of intestinal core 1–derived O-glycans causes spontaneous colitis in mice

Fu, J., Wei, B., Wen, T., Johansson, M. E. V., Liu, X., Bradford, E., Thomsson, K. A., McGee, S., Mansour, L., Tong, M., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45538 · Cited by 366 · see citing works

Genetic basis for increased intestinal permeability in families with Crohn’s disease: role of CARD15 3020insC mutation?

Bühner, S., Büning, C., Genschel, J., Kling, K., Herrmann, D., Dignass, A., Kuechler, I., Krueger, S., Schmidt, H. H.-J., & Lochs, H. (2005) · Gut · doi:10.1136/gut.2005.065557 · Cited by 366 · see citing works

NOD mouse colonies around the world- recent facts and figures

Pozzilli, P., Signore, A., Williams, A. J. K., & Beales, P. E. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90160-m · Cited by 349 · see citing works

Tricellulin Forms a Barrier to Macromolecules in Tricellular Tight Junctions without Affecting Ion Permeability

Krug, S. M., Amasheh, S., Richter, J. F., Milatz, S., Günzel, D., Westphal, J. K., Huber, O., Schulzke, J. D., & Fromm, M. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-01-0080 · Cited by 345 · see citing works

Intestinal absorptive cell tight junctions are linked to cytoskeleton

Madara, J. (1987) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1987.253.1.c171 · Cited by 342 · see citing works

Tumor necrosis factor- alpha production to lipopolysaccharide stimulation by donor cells predicts the severity of experimental acute graft-versus-host disease.

Cooke, K. R., Hill, G. R., Crawford, J. M., Bungard, D., Brinson, Y. S., Delmonte, J., & Ferrara, J. L. (1998) · Journal of Clinical Investigation · doi:10.1172/jci4285 · Cited by 336 · see citing works

Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT

Carlton, V. E. H., Harris, B. Z., Puffenberger, E. G., Batta, A. K., Knisely, A. S., Robinson, D. L., Strauss, K. A., Shneider, B. L., Lim, W. A., Salen, G., et al. (2003) · Nature Genetics · doi:10.1038/ng1147 · Cited by 327 · see citing works

Tight Junction–associated MARVEL Proteins MarvelD3, Tricellulin, and Occludin Have Distinct but Overlapping Functions

Raleigh, D. R., Marchiando, A. M., Zhang, Y., Shen, L., Sasaki, H., Wang, Y., Long, M., & Turner, J. R. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-08-0734 · Cited by 326 · see citing works

Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse

Arrieta, M., Madsen, K. L., Doyle, J. S. G., & Meddings, J. B. (2008) · Gut · doi:10.1136/gut.2008.150888 · Cited by 324 · see citing works

Epithelial transport and barrier function in occludin-deficient mice

Schulzke, J., Gitter, A. H., Mankertz, J., Spiegel, S., Seidler, U. E., Amasheh, S., Saitou, M., Tsukita, S., & Fromm, M. (2005) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2005.01.008 · Cited by 320 · see citing works

Interleukin-10 Gene-Deficient Mice Develop a Primary Intestinal Permeability Defect in Response to Enteric Microflora

Madsen, K. L., Malfair, D., Gray, D., Doyle, J. S. G., Jewell, L. D., & Fedorak, R. N. (1999) · Inflammatory Bowel Diseases · doi:10.1097/00054725-199911000-00004 · Cited by 318 · see citing works

Is small intestinal permeability really increased in relatives of patients with Crohn's disease?

May, G. R., Sutherland, L. R., & Meddings, J. B. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90638-s · Cited by 316 · see citing works

Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats

Watts, T. L., Berti, I., Sapone, A., Gerarduzzi, T., Not, T., Zielke, R. H., & Fasano, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500178102 · Cited by 313 · see citing works

Molecular Basis for Cation Selectivity in Claudin-2–based Paracellular Pores: Identification of an Electrostatic Interaction Site

Yu, A. S. L., Cheng, M. H., Angelow, S., Günzel, D., Kanzawa, S. A., Schneeberger, E. E., Fromm, M., & Coalson, R. D. (2008) · The Journal of General Physiology · doi:10.1085/jgp.200810154 · Cited by 310 · see citing works

IFN-γ-Induced TNFR2 Expression Is Required for TNF-Dependent Intestinal Epithelial Barrier Dysfunction

Wang, F., Schwarz, B. T., Graham, W. V., Wang, Y., Su, L., Clayburgh, D. R., Abraham, C., & Turner, J. R. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.08.022 · Cited by 305 · see citing works

ABNORMAL INTESTINAL PERMEABILITY TO SUGARS IN VILLOUS ATROPHY

Menzies, I. S., Pounder, R. E., Heyer, S., et al. (1979) · The Lancet · doi:10.1016/s0140-6736(79)92507-8 · Cited by 302 · see citing works

Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease

Blair, S. A., Kane, S. V., Clayburgh, D. R., & Turner, J. R. (2006) · Laboratory Investigation · doi:10.1038/labinvest.3700373 · Cited by 298 · see citing works

Deficiency of Zonula Occludens-1 Causes Embryonic Lethal Phenotype Associated with Defected Yolk Sac Angiogenesis and Apoptosis of Embryonic Cells

Katsuno, T., Umeda, K., Matsui, T., Hata, M., Tamura, A., Itoh, M., Takeuchi, K., Fujimori, T., Nabeshima, Y.-I., Noda, T., et al. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-12-1215 · Cited by 297 · see citing works

Epithelial Myosin Light Chain Kinase Activation Induces Mucosal Interleukin-13 Expression to Alter Tight Junction Ion Selectivity

Weber, C. R., Raleigh, D. R., Su, L., Shen, L., Sullivan, E. A., Wang, Y., & Turner, J. R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.064808 · Cited by 296 · see citing works

Mutations in TJP2 cause progressive cholestatic liver disease

Sambrotta, M., Strautnieks, S. S., Papouli, E., Rushton, P., Clark, B. E., Parry, D. A., Logan, C. V., Newbury, L. J., Kamath, B. M., Ling, S. C., et al. (2014) · Nature Genetics · doi:10.1038/ng.2918 · Cited by 295 · see citing works

Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal Permeability

Luther, J., Garber, J. J., Khalili, H., Dave, M., Bale, S. S., Jindal, R., Motola, D. L., Luther, S., Bohr, S., Jeoung, S. W., et al. (2015) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2015.01.001 · Cited by 286 · see citing works

Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk

Irvine, E. J., & Marshall, J. K. (2000) · Gastroenterology · doi:10.1053/gast.2000.20231 · Cited by 286 · see citing works

Tricellulin is a tight-junction protein necessary for hearing

Riazuddin, S., Ahmed, Z. M., Fanning, A. S., Lagziel, A., Kitajiri, S.-I., Ramzan, K., Khan, S. N., Chattaraj, P., Friedman, P. L., Anderson, J. M., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/510022 · Cited by 283 · see citing works

The Epithelial Barrier Is Maintained by In Vivo Tight Junction Expansion During Pathologic Intestinal Epithelial Shedding

Marchiando, A. M., Shen, L., Graham, W. V., Edelblum, K. L., Duckworth, C. A., Guan, Y., Montrose, M. H., Turner, J. R., & Watson, A. J. M. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.01.004 · Cited by 276 · see citing works

Rapid development of colitis in NSAID-treated IL-10–deficient mice

Berg, D., Zhang, J., Weinstock, J. V., Ismail, H. F., Earle, K. A., Alila, H. W., Pamukcu, R., Moore, S. A., & Lynch, R. G. (2002) · Gastroenterology · doi:10.1053/gast.2002.1231527 · Cited by 276 · see citing works

Evidence for the lipidic nature of tight junction strands

Kachar, B., & Reese, T. S. (1982) · Nature · doi:10.1038/296464a0 · Cited by 276 · see citing works

Foxl1-Expressing Mesenchymal Cells Constitute the Intestinal Stem Cell Niche

Aoki, R., Shoshkes-Carmel, M., Gao, N., Shin, S., May, C. L., Golson, M. L., Zahm, A. M., Ray, M., Wiser, C. L., Wright, C. V. E., et al. (2015) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2015.12.004 · Cited by 275 · see citing works

Crohn's disease--a permeability disorder of the tight junction?

Hollander, D. (1988) · Gut · doi:10.1136/gut.29.12.1621 · Cited by 271 · see citing works

Epithelial barrier defects in ulcerative colitis: Characterization and quantification by electrophysiological imaging

Gitter, A. H., Wullstein, F., Fromm, M., & Schulzke, J. D. (2001) · Gastroenterology · doi:10.1053/gast.2001.29694 · Cited by 270 · see citing works

Pathology of graft-versus-host disease in the gastrointestinal tract

Washington, K. M., & Jagasia, M. (2009) · Human Pathology · doi:10.1016/j.humpath.2009.04.001 · Cited by 261 · see citing works

Loss of Claudin-15, but Not Claudin-2, Causes Na+ Deficiency and Glucose Malabsorption in Mouse Small Intestine

Tamura, A., Hayashi, H., Imasato, M., Yamazaki, Y., Hagiwara, A., Wada, M., Noda, T., 渡辺, 光., Suzuki, Y., & Tsukita, S. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.08.006 · Cited by 258 · see citing works

Depletion of E-Cadherin Disrupts Establishment but Not Maintenance of Cell Junctions in Madin-Darby Canine Kidney Epithelial Cells

Capaldo, C., & Macara, I. G. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-05-0471 · Cited by 258 · see citing works

Unique Role of Junctional Adhesion Molecule-A in Maintaining Mucosal Homeostasis in Inflammatory Bowel Disease

Vetrano, S., Rescigno, M., Cera, M. R., Correale, C., Rumio, C., Doni, A., Fantini, M. C., Sturm, A., Borroni, E. M., Repici, A., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.04.002 · Cited by 254 · see citing works

Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function

Raleigh, D. R., Boe, D. M., Yu, D., Weber, C. R., Marchiando, A. M., Bradford, E. M., Wang, Y., Wu, L., Schneeberger, E. E., Shen, L., et al. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201010065 · Cited by 251 · see citing works

IL-10R Polymorphisms Are Associated with Very-early-onset Ulcerative Colitis

Moran, C. J., Walters, T. D., Guo, C., Kugathasan, S., Klein, C., Turner, D., Wolters, V. M., Bandsma, R., Mouzaki, M., Zachos, M., et al. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.22974 · Cited by 245 · see citing works

Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect

Monsuur, A. J., de Bakker, P. I. W., Alizadeh, B. Z., Zhernakova, A., Bevova, M. R., Strengman, E., Franke, L., Slot, R. V. ‘., van Belzen, M. J., Lavrijsen, I. C. M., et al. (2005) · Nature Genetics · doi:10.1038/ng1680 · Cited by 243 · see citing works

Maintenance of the macromolecular barrier at cell extrusion sites in intestinal epithelium: Physiological rearrangement of tight junctions

Madara, J. (1990) · The Journal of Membrane Biology · doi:10.1007/bf01868675 · Cited by 242 · see citing works

Enteropathogenic Escherichia coli-induced myosin light chain phosphorylation alters intestinal epithelial permeability

Yuhan, R., Koutsouris, A., Savkovic, S., & Hecht, G. A. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70006-4 · Cited by 239 · see citing works

Enterohemorrhagic Escherichia coli Reduces Mucus and Intermicrovillar Bridges in Human Stem Cell-Derived Colonoids

In, J., Foulke-Abel, J., Zachos, N. C., Hansen, A.-M., Kaper, J. B., Bernstein, H. D., Halushka, M., Blutt, S., Estes, M. K., Donowitz, M., et al. (2016) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2015.10.001 · Cited by 239 · see citing works

Antibiotic therapy attenuates colitis in interleukin 10 gene–deficient mice

Madsen, K. L., Doyle, J. S. G., Tavernini, M. M., Jewell, L. D., Rennie, R. P., & Fedorak, R. N. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70362-3 · Cited by 232 · see citing works

A Disease-Associated Microbial and Metabolomics State in Relatives of Pediatric Inflammatory Bowel Disease Patients

Jacobs, J. P., Goudarzi, M., Singh, N., Tong, M., McHardy, I. H., Ruegger, P. M., Asadourian, M., Moon, B., Ayson, A., Borneman, J., et al. (2016) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.06.004 · Cited by 230 · see citing works

Intestinal permeability in children with Crohn's disease and coeliac disease.

Pearson, A., EASTHAM, E. J., Laker, M. F., Craft, A. W., & NELSON, R. L. (1982) · BMJ · doi:10.1136/bmj.285.6334.20 · Cited by 225 · see citing works

Physiological regulation of transepithelial impedance in the intestinal mucosa of rats and hamsters

Pappenheimer, J. R. (1987) · The Journal of Membrane Biology · doi:10.1007/bf02209146 · Cited by 222 · see citing works

Intestinal Permeability Test As A Predictor of Clinical Course in Crohn's Disease

Renata D'Incà, Leo, V. D., Corrao, G., Martines, D., D’Odorico, A., Mestriner, C., Venturi, C., Longo, G., & Sturniolo, G. C. (1999) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01444.x · Cited by 218 · see citing works

Loss of Occludin Affects Tricellular Localization of Tricellulin

Ikenouchi, J., Sasaki, H., Tsukita, S., Furuse, M., & Tsukita, S. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-05-0530 · Cited by 212 · see citing works

Occludin is required for cytokine-induced regulation of tight junction barriers

Itallie, C. M. V., Fanning, A. S., Holmes, J. C., & Anderson, J. M. (2010) · Journal of Cell Science · doi:10.1242/jcs.065581 · Cited by 209 · see citing works

A Key Role for E-cadherin in Intestinal Homeostasis and Paneth Cell Maturation

Schneider, M. R., Dahlhoff, M., Horst, D. A., Hirschi, B., Trülzsch, K., Müller‐Höcker, J., Vogelmann, R., Allgäuer, M., Gerhard, M., Steininger, S., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014325 · Cited by 206 · see citing works

Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin

Saitoh, Y., Suzuki, H., Tani, K., Nishikawa, K., Irie, K., Ogura, Y., Tamura, A., Tsukita, S., & Fujiyoshi, Y. (2015) · Science · doi:10.1126/science.1261833 · Cited by 205 · see citing works

Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo

Clayburgh, D. R., Musch, M. W., Leitges, M., Fu, Y., & Turner, J. R. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29218 · Cited by 203 · see citing works

Larazotide acetate in patients with coeliac disease undergoing a gluten challenge: a randomised placebo‐controlled study

Kelly, C. P., Green, P. H. R., Murray, J. A., DiMarino, A. J., Colatrella, A. M., Leffler, D. A., Alexander, T., Arsenescu, R. I., León, F., Jiang, J. G., et al. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12147 · Cited by 201 · see citing works

The role of molecular remodeling in differential regulation of tight junction permeability

Turner, J. R., Buschmann, M. M., Romero-Calvo, I., Sailer, A., & Shen, L. (2014) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2014.09.022 · Cited by 200 · see citing works

Early Embryonic Lethality of Mice Lacking ZO-2, but Not ZO-3, Reveals Critical and Nonredundant Roles for Individual Zonula Occludens Proteins in Mammalian Development

Xu, J., Kausalya, P. J., Phua, D. C. Y., Ali, S. M., Hossain, Z., & Hunziker, W. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00891-07 · Cited by 196 · see citing works

Ultrastructural mucosal alterations and increased intestinal permeability in non-celiac, type I diabetic patients

Secondulfo, M., Iafusco, D., Carratu, R., deMagistris, L., Sapone, A., Generoso, M., Mezzogiorno, A., Sasso, F. C., Cartenı̀, M., Rosa, R. D., et al. (2003) · Digestive and Liver Disease · doi:10.1016/j.dld.2003.09.016 · Cited by 193 · see citing works

Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux

Buschmann, M. M., Shen, L., Rajapakse, H., Raleigh, D. R., Wang, Y., Wang, Y., Lingaraju, A., Zha, J., Abbott, E., McAuley, E. M., et al. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-09-0688 · Cited by 192 · see citing works

Clostridium difficile toxin B disrupts the barrier function of T84 monolayers

Hecht, G. A., Koutsouris, A., Pothoulakis, C., LaMont, J. T., & Madara, J. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)90085-d · Cited by 191 · see citing works

Abnormal Small Intestinal Permeability to Sugars in Patients with Crohn’s Disease of the Terminal Ileum and Colon

Ukabam, S. O., Clamp, J. R., & Cooper, B. T. (2009) · Digestion · doi:10.1159/000198932 · Cited by 191 · see citing works

The Gut Microbiota and Liver Disease

Llorente, C., & Schnabl, B. (2015) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2015.04.003 · Cited by 189 · see citing works

Partitioning of paracellular conductance along the ileal crypt-villus axis: A hypothesis based on structural analysis with detailed consideration of tight junction structure-function relationships

Marcial, M. A., Carlson, S., & Madara, J. (1984) · The Journal of Membrane Biology · doi:10.1007/bf01868690 · Cited by 189 · see citing works

A Randomized, Double-Blind Study of Larazotide Acetate to Prevent the Activation of Celiac Disease During Gluten Challenge

Leffler, D. A., Kelly, C. P., Abdallah, H., Colatrella, A. M., Harris, L. A., León, F., Arterburn, L. A., Paterson, B. M., Lan, Z. H., & Murray, J. A. (2012) · The American Journal of Gastroenterology · doi:10.1038/ajg.2012.211 · Cited by 186 · see citing works

Loss of Claudins 2 and 15 From Mice Causes Defects in Paracellular Na+ Flow and Nutrient Transport in Gut and Leads to Death from Malnutrition

Wada, M., Tamura, A., Takahashi, N., & Tsukita, S. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.10.035 · Cited by 185 · see citing works

Increased gastrointestinal permeability is an early lesion in the spontaneously diabetic BB rat

Meddings, J. B., Jarand, J. M., Urbanski, S. J., Hardin, J. W., & Gall, D. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.276.4.g951 · Cited by 185 · see citing works

Myosin Light Chain Kinase Is Central to Smooth Muscle Contraction and Required for Gastrointestinal Motility in Mice

He, W., Peng, Y., Zhang, W., Lv, N., Tang, J. P., Chen, C., Zhang, C., Gao, S., Chen, H., Zhi, G., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.05.032 · Cited by 184 · see citing works

Abnormal Intestinal Permeability Predicts Relapse in Inactive Crohn Disease

Arnott, K. K. I. D. R. (2000) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655200750056637 · Cited by 184 · see citing works

In tight junctions, claudins regulate the interactions between occludin, tricellulin and marvelD3, which, inversely, modulate claudin oligomerization

Cording, J., Berg, J., Käding, N., Bellmann, C., Tscheik, C., Westphal, J. K., Milatz, S., Günzel, D., Wolburg, H., Piontek, J., et al. (2012) · Journal of Cell Science · doi:10.1242/jcs.114306 · Cited by 182 · see citing works

Rapid disruption of intestinal barrier function by gliadin involves altered expression of apical junctional proteins

Sander, G. R., Cummins, A. G., & Powell, B. C. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.07.066 · Cited by 180 · see citing works

Intestinal permeability in patients with coeliac disease and relatives of patients with coeliac disease.

van Elburg, R. M., Uil, J. J., Mulder, C. J. J., & Heymans, H. S. A. (1993) · Gut · doi:10.1136/gut.34.3.354 · Cited by 179 · see citing works

Wnt, stem cells and cancer in the intestine

Pinto, D., & Clevers, H. C. (2005) · Biology of the Cell · doi:10.1042/bc20040094 · Cited by 175 · see citing works

The primary defect in experimental ileitis originates from a nonhematopoietic source

Olson, T. S., Reuter, B. K., Scott, K. G. –., MORRIS, M. A., Wang, X.-M., Hancock, L. N., Burcin, T. L., Cohn, S. M., Ernst, P. B., Cominelli, F., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20050407 · Cited by 172 · see citing works

Yamada' s Textbook of Gastroenterology

(2015) · Wiley eBooks · doi:10.1002/9781118512074 · Cited by 168 · see citing works

TNFα up-regulates claudin-2 expression in epithelial HT-29/B6 cells via phosphatidylinositol-3-kinase signaling

Mankertz, J., Amasheh, M., Krug, S. M., Fromm, A., Amasheh, S., Hillenbrand, B., Tavalali, S., Fromm, M., & Schulzke, J. (2009) · Cell and Tissue Research · doi:10.1007/s00441-009-0751-8 · Cited by 162 · see citing works

Permeability of the rat small intestinal epithelium along the villus-crypt axis: Effects of glucose transport

Fihn, B., Sjöqvist, A., & Jodal, M. (2000) · Gastroenterology · doi:10.1053/gast.2000.18148 · Cited by 161 · see citing works

Tumor Necrosis Factor-induced Long Myosin Light Chain Kinase Transcription Is Regulated by Differentiation-dependent Signaling Events

Graham, W. V., Wang, F., Clayburgh, D. R., Cheng, J. X., Yoon, B., Wang, Y., Lin, A., & Turner, J. R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602164200 · Cited by 146 · see citing works

Intestinal absorptive capacity, intestinal permeability and jejunal histology in HIV and their relation to diarrhoea.

Keating, J. J., Bjarnason, I., Somasundaram, S. G., Macpherson, A. J., Francis, N., Price, A. B., Sharpstone, D. R., Smithson, J., Menzies, I. S., & Gazzard, B. (1995) · Gut · doi:10.1136/gut.37.5.623 · Cited by 145 · see citing works

A major non-HLA locus in celiac disease maps to chromosome 191 1This study is dedicated to the memory of Lodewijk Sandkuijl (1953–2002), who died shortly after its completion. He was an inspiration to us and was a world expert on biostatistics.

van Belzen, M. J., Meijer, J. W. R., Sandkuijl, L. A., et al. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)01205-8 · Cited by 145 · see citing works

Leaky gut – concept or clinical entity?

Quigley, E. M. M. (2016) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000243 · Cited by 139 · see citing works

R-spondin1, A Novel Intestinotrophic Mitogen, Ameliorates Experimental Colitis in Mice

Zhao, J., Vera, J. D., Narushima, S., Beck, E. X., Palencia, S., Shinkawa, P., Kim, K., Liu, Y., Levy, M. D., Berg, D., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.02.001 · Cited by 138 · see citing works

Intestinal barrier loss as a critical pathogenic link between inflammatory bowel disease and graft-versus-host disease

Nalle, S. C., & Turner, J. R. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.40 · Cited by 137 · see citing works

p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice

Smalley-Freed, W. G., Efimov, A., Burnett, P. E., Short, S. P., Davis, M. A., Gumucio, D. L., Washington, M. K., Coffey, R. J., & Reynolds, A. B. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41414 · Cited by 137 · see citing works

Gut barrier disruption by an enteric bacterial pathogen accelerates insulitis in NOD mice

Lee, A., Gibson, D. L., Zhang, Y., Sham, H. P., Vallance, B. A., & Dutz, J. P. (2009) · Diabetologia · doi:10.1007/s00125-009-1626-y · Cited by 129 · see citing works

Cell polarity-determining proteins Par-3 and PP-1 are involved in epithelial tight junction defects in coeliac disease

Schümann, M., Günzel, D., Bürgel, N., Richter, J. F., Troeger, H., May, C., Fromm, A., Sorgenfrei, D., Daum, S., Bojarski, C., et al. (2011) · Gut · doi:10.1136/gutjnl-2011-300123 · Cited by 128 · see citing works

Gliadin-dependent neuromuscular and epithelial secretory responses in gluten-sensitive HLA-DQ8 transgenic mice

Verdu, E. F., Huang, X., Natividad, J. M., Lu, J., Blennerhassett, P. A., David, C. S., McKay, D. M., & Murray, J. A. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00225.2007 · Cited by 125 · see citing works

Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure

Russo, J. M., Florian, P., Shen, L., Graham, W. V., Tretiakova, M., Gitter, A. H., Mrsny, R. J., & Turner, J. R. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.01.004 · Cited by 122 · see citing works

Gastrointestinal permeability in celiac disease

Smecuol, E., Bai, J., Vázquez, H., Kogan, Z., Cabanne, A., Niveloni, S. I., Pedreira, S. C., Boerr, L., Mauriño, E. C., & Meddings, J. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70123-9 · Cited by 120 · see citing works

Genetic Variation in Myosin IXB Is Associated With Ulcerative Colitis

Bodegraven, A. A. V., Curley, C., Hunt, K. A., Monsuur, A. J., Linskens, R. K., Onnie, C. M., Crusius, J. B. A., Annese, V., Latiano, A., Silverberg, M. S., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.09.011 · Cited by 119 · see citing works

Intestinal permeability in coeliac disease: the response to gluten withdrawal and single-dose gluten challenge.

Hamilton, I., Cobden, I., Rothwell, J. F., et al. (1982) · Gut · doi:10.1136/gut.23.3.202 · Cited by 119 · see citing works

Larazotide acetate regulates epithelial tight junctions in vitro and in vivo

Gopalakrishnan, S., Durai, M., Kitchens, K. M., Tamiz, A. P., Somerville, R. P. T., Ginski, M. J., Paterson, B. M., Murray, J. A., Verdu, E. F., Alkan, Ş. Ş., et al. (2012) · Peptides · doi:10.1016/j.peptides.2012.02.015 · Cited by 117 · see citing works

Rapid reduction of MDCK cell cholesterol by methyl-β-cyclodextrin alters steady state transepithelial electrical resistance

Francis, S. A., Kelly, J. M., McCormack, J. M., Rogers, R. A., Lai, J., Schneeberger, E. E., & Lynch, R. D. (1999) · European Journal of Cell Biology · doi:10.1016/s0171-9335(99)80074-0 · Cited by 115 · see citing works

Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria.

Maes, M. H. J., & Leunis, J. (2008) · PubMed · Cited by 115 · see citing works

Gastrointestinal permeability in celiac disease

Oberhuber, G., & Vogelsang, H. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70661-4 · Cited by 114 · see citing works

Human myosin-IXb, an unconventional myosin with a chimerin-like rho/rac GTPase-activating protein domain in its tail

Wirth, J. A., Jensen, K. A., Post, P. L., Bement, W. M., & Mooseker, M. S. (1996) · Journal of Cell Science · doi:10.1242/jcs.109.3.653 · Cited by 112 · see citing works

Complex Roles of Caspases in the Pathogenesis of Inflammatory Bowel Disease

Becker, C., Watson, A. J. M., & Neurath, M. F. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.11.035 · Cited by 107 · see citing works

Human myosin-IXb is a mechanochemically active motor and a GAP for rho

Post, P. L., Bokoch, G., & Mooseker, M. S. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.7.941 · Cited by 106 · see citing works

Claudin-2-dependent paracellular channels are dynamically gated

Weber, C. R., Liang, G. H., Wang, Y., Das, S., Shen, L., Yu, A. S. L., Nelson, D. J., & Turner, J. R. (2015) · eLife · doi:10.7554/elife.09906 · Cited by 106 · see citing works

Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis

Yamaoka, T., Yan, F., Cao, H., Hobbs, S. S., Dise, R. S., Tong, W., & Polk, D. B. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801463105 · Cited by 105 · see citing works

Tricellulin deficiency affects tight junction architecture and cochlear hair cells

Nayak, G., Lee, S. I., Yousaf, R., Edelmann, S. E., Trincot, C. E., Itallie, C. M. V., Sinha, G. P., Rafeeq, M., Jones, S. M., Belyantseva, I. A., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69031 · Cited by 102 · see citing works

The secret life of α-catenin: Moonlighting in morphogenesis

Maiden, S. L., & Hardin, J. D. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201103106 · Cited by 102 · see citing works

Tumor necrosis factor inhibitor ameliorates murine intestinal graft-versus-host disease

Brown, G., Lindberg, G. M., Meddings, J. B., Silva, M., Beutler, B., & Thiele, D. L. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70181-2 · Cited by 97 · see citing works

The Development of Spasmolytic Polypeptide/TFF2-Expressing Metaplasia (SPEM) During Gastric Repair Is Absent in the Aged Stomach

Engevik, A. C., Feng, R., Choi, E.-Y. K., White, S., Bertaux‐Skeirik, N., Li, J., Mahé, M. M., Aihara, E., Li, Y., DiPasquale, B. A., et al. (2016) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.05.004 · Cited by 97 · see citing works

CALCIUM CHANNEL AUTOANTIBODIES IN LAMBERT-EATON MYASTHENIC SYNDROME

Leys, K., Lang, B., Vincent, A. C., et al. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91129-x · Cited by 95 · see citing works

Claudin 2 Deficiency Reduces Bile Flow and Increases Susceptibility to Cholesterol Gallstone Disease in Mice

Matsumoto, K., Imasato, M., Yamazaki, Y., Tanaka, H., 渡辺, 光., Eguchi, H., Nagano, H., Hikita, H., Tatsumi, T., Takehara, T., et al. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.07.033 · Cited by 94 · see citing works

Zonula occludens (ZO)-1 and ZO-2: membrane-associated guanylate kinase homologues (MAGuKs) of the tight junction

Anderson, J. M., Fanning, A. S., Lapierre, L. A., & Itallie, C. M. V. (1995) · Biochemical Society Transactions · doi:10.1042/bst0230470 · Cited by 91 · see citing works

Alterations in classical cadherins associated with progression in ulcerative and Crohn's colitis.

Jankowski, J. A., Bedford, F. K., Boulton, R., Cruickshank, N., Hall, C., Elder, J. T., Allan, R. N., Forbes, A., Kim, Y. S., Wright, N. A., et al. (1998) · PubMed · Cited by 89 · see citing works

Inflammatory bowel disease: lessons from the IL-10 gene-deficient mouse.

Madsen, K. L. (2001) · PubMed · Cited by 89 · see citing works

Increased intestinal permeability and tight junction disruption by altered expression and localization of occludin in a murine graft versus host disease model

Noth, R., Lange-Grumfeld, J., Stuber, E. R., Kruse, M., Ellrichmann, M., Häsler, R., Hampe, J., Bewig, B., Rosenstiel, P. C., Schreiber, S., et al. (2011) · BMC Gastroenterology · doi:10.1186/1471-230x-11-109 · Cited by 86 · see citing works

Show me the pathway!

Turner, J. R. (2000) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00046-6 · Cited by 85 · see citing works

Epidermal growth factor receptor inhibits colitis-associated cancer in mice

Dubé, P. E., Yan, F., Punit, S., Girish, N., McElroy, S. J., Washington, M. K., & Polk, D. B. (2012) · Journal of Clinical Investigation · doi:10.1172/jci62888 · Cited by 85 · see citing works

Brush border cytoskeleton and integration of cellular functions.

Mooseker, M. S., Bonder, E. M., Conzelman, K. A., et al. (1984) · The Journal of Cell Biology · doi:10.1083/jcb.99.1.104s · Cited by 83 · see citing works

ZO-1 recruitment to α-catenin: a novel mechanism for coupling the assembly of tight junctions to adherens junctions

Maiers, J. L., Peng, X. L., Fanning, A. S., & DeMali, K. A. (2013) · Journal of Cell Science · doi:10.1242/jcs.126565 · Cited by 80 · see citing works

Abnormal permeability precedes the development of a gluten sensitive enteropathy in Irish setter dogs.

Hall, E. J., & Batt, R. M. (1991) · Gut · doi:10.1136/gut.32.7.749 · Cited by 80 · see citing works

Mucosal expression of claudins 2, 3 and 4 in proximal and distal part of duodenum in children with coeliac disease

Szakál, D. N., Győrffy, H., Arató, A., et al. (2010) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-009-0879-7 · Cited by 79 · see citing works

Luminal nutrients alter tight-junction permeability in the rat jejunum: an in vivo perfusion model

Sadowski, D. C., & Meddings, J. B. (1993) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y93-125 · Cited by 77 · see citing works

Myosin Light Chain Kinase Is Necessary for Tonic Airway Smooth Muscle Contraction

Zhang, W., Peng, Y.-J., Zhang, G., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.062836 · Cited by 76 · see citing works

Noninvasive In vivo Analysis of Human Small Intestinal Paracellular Absorption: Regulation by Na+-Glucose Cotransport

Turner, J. R., Cohen, D. E., Mrsny, R. J., & Madara, J. L. (2000) · Digestive Diseases and Sciences · doi:10.1023/a:1026682900586 · Cited by 74 · see citing works

Host Responses to Intestinal Microbial Antigens in Gluten-Sensitive Mice

Natividad, J. M., Huang, X., Slack, E., Jury, J., Sanz, Y., David, C., Denou, E., Yang, P., Murray, J., McCoy, K. D., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006472 · Cited by 73 · see citing works

Conceptual barriers to understanding physical barriers

Lingaraju, A., Long, T. M., Wang, Y., Austin, J. R., & Turner, J. R. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.04.008 · Cited by 72 · see citing works

Increased permeability of macroscopically normal small bowel in Crohn's disease

Peeters, M., Ghoos, Y. F., Maes, B., Hiele, M. I., Geboes, K. J., Vantrappen, G., & Rutgeerts, P. (1994) · Digestive Diseases and Sciences · doi:10.1007/bf02090367 · Cited by 72 · see citing works

Lack of association of MYO9B genetic variants with coeliac disease in a British cohort

Hunt, K. A., Monsuur, A. J., McArdle, W. L., et al. (2006) · Gut · doi:10.1136/gut.2005.086769 · Cited by 72 · see citing works

Toll-Like Receptor 4-Mediated Regulation of Spontaneous Helicobacter-Dependent Colitis in IL-10–Deficient Mice

Matharu, K., Mizoguchi, E., Alonso, C., Nguyen, D. D., Mingle, B., Iweala, O. I., McBee, M. E., Stefka, A. T., Prioult, G., Haigis, K. M., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.07.004 · Cited by 69 · see citing works

c‐Jun N‐terminal kinase is largely involved in the regulation of tricellular tight junctions via tricellulin in human pancreatic duct epithelial cells

Kojima, T., Fuchimoto, J., Yamaguchi, H., Ito, T., Takasawa, A., Ninomiya, T., Kikuchi, S., Ogasawara, N., Ohkuni, T., Masaki, T., et al. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22273 · Cited by 68 · see citing works

Assessment of the lactulose-mannitol test in Crohn's disease.

Andre, F., Andre, C., Emery, Y., Forichon, J., Descos, L., & Minaire, Y. (1988) · Gut · doi:10.1136/gut.29.4.511 · Cited by 67 · see citing works

Passage of molecules through the wall of the gastrointestinal tract. II. Application of low-molecular weight polyethyleneglycol and a deterministic mathematical model for determining intestinal permeability in man.

Sundqvist, T., Magnusson, K., Sjödahl, R., et al. (1980) · Gut · doi:10.1136/gut.21.3.208 · Cited by 66 · see citing works

Deafness in occludin-deficient mice with dislocation of tricellulin and progressive apoptosis of the hair cells

Kitajiri, S., Katsuno, T., Sasaki, H., Ito, J., Furuse, M., & Tsukita, S. (2014) · Biology Open · doi:10.1242/bio.20147799 · Cited by 65 · see citing works

Microecology, obesity, and probiotics

Tennyson, C. A., & FRIEDMAN, G. J. (2008) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e328308dbfb · Cited by 61 · see citing works

Intestinal glucose transport using perfused rat jejunum in vivo: model analysis and derivation of corrected kinetic constants

Meddings, J. B., & Westergaard, H. (1989) · Clinical Science · doi:10.1042/cs0760403 · Cited by 61 · see citing works

Role of myosin light chain kinase in regulation of basal blood pressure and maintenance of salt-induced hypertension

He, W., Qiao, Y., Zhang, C., Peng, Y.-J., Chen, C., Wang, P., Gao, Y., Chen, C., Chen, X., Tao, T., et al. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01212.2010 · Cited by 59 · see citing works

An insight into gut microbiota and its functionalities

Adak, A., & Khan, M. R. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2943-4 · Cited by 1,485 · see citing works

The gut-liver axis and the intersection with the microbiome

Tripathi, A., Debelius, J., Brenner, D. A., Karin, M., Loomba, R., Schnabl, B., & Knight, R. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0011-z · Cited by 1,480 · see citing works

Leaky gut: mechanisms, measurement and clinical implications in humans

Camilleri, M. (2019) · Gut · doi:10.1136/gutjnl-2019-318427 · Cited by 1,081 · see citing works

Regulation of Intestinal Barrier Function by Microbial Metabolites

Ghosh, S., Whitley, C. S., Haribabu, B., & Jala, V. R. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.02.007 · Cited by 835 · see citing works

Underestimated health risks: polystyrene micro- and nanoplastics jointly induce intestinal barrier dysfunction by ROS-mediated epithelial cell apoptosis

Liang, B., Zhong, Y., Huang, Y., Lin, X., Liu, J., Lin, L., Hu, M., Jiang, J., Dai, M., Wang, B., et al. (2021) · Particle and Fibre Toxicology · doi:10.1186/s12989-021-00414-1 · Cited by 508 · see citing works

Hallmarks of Health

López-Otín, C., & Kroemer, G. (2021) · Cell · doi:10.1016/j.cell.2020.11.034 · Cited by 499 · see citing works

Flavonoids and the gastrointestinal tract: local and systemic effects

Oteiza, P. I., Fraga, C. G., Mills, D. A., & Taft, D. H. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.01.001 · Cited by 281 · see citing works

Obesity in Type 1 Diabetes: Pathophysiology, Clinical Impact, and Mechanisms

Corbin, K. D., Driscoll, K. A., Pratley, R. E., Smith, S. R., Maahs, D. M., Mayer-Davis, E. J., & Advancing Care for Type 1 Diabetes and Obesity Network (ACT1ON) (2018) · Endocrine Reviews · doi:10.1210/er.2017-00191 · Cited by 262 · see citing works

The intestinal barrier in disorders of the central nervous system

Pellegrini, C., Fornai, M., D'Antongiovanni, V., Antonioli, L., Bernardini, N., & Derkinderen, P. (2023) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(22)00241-2 · Cited by 239 · see citing works

Intestinal Barrier Dysfunction in Irritable Bowel Syndrome: A Systematic Review

Hanning, N., Edwinson, A. L., Ceuleers, H., Peters, S. A., De Man, J. G., Hassett, L. C., De Winter, B. Y., & Grover, M. (2021) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756284821993586 · Cited by 197 · see citing works

Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis

Graham, W. V., He, W., Marchiando, A. M., Zha, J., Singh, G., Li, H.-S., Biswas, A., Ong, M. L. D. M., Jiang, Z.-H., Choi, W., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0393-7 · Cited by 176 · see citing works

Celiac Disease and the Microbiome

Valitutti, F., Cucchiara, S., & Fasano, A. (2019) · Nutrients · doi:10.3390/nu11102403 · Cited by 157 · see citing works

The gut microbiota-brain axis, psychobiotics and its influence on brain and behaviour: a systematic review

Barrio, C., Arias-Sánchez, S., & Martín-Monzón, I. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105640 · Cited by 143 · see citing works

The emerging roles of bacterial proteases in intestinal diseases

Caminero, A., Guzman, M., Libertucci, J., & Lomax, A. E. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2181922 · Cited by 92 · see citing works

Role of the endocannabinoid system in the regulation of intestinal homeostasis

Cuddihey, H., MacNaughton, W. K., & Sharkey, K. A. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.05.015 · Cited by 79 · see citing works

Multi-Pharmacology of Berberine in Atherosclerosis and Metabolic Diseases: Potential Contribution of Gut Microbiota

Yang, S., Li, D., Yu, Z., Li, Y., & Wu, M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.709629 · Cited by 40 · see citing works

Epithelial production of elastase is increased in inflammatory bowel disease and causes mucosal inflammation

Motta, J.-P., Rolland, C., Edir, A., Florence, A.-C., Sagnat, D., Bonnart, C., Rousset, P., Guiraud, L., Quaranta-Nicaise, M., Mas, E., et al. (2021) · Mucosal Immunology · doi:10.1038/s41385-021-00375-w · Cited by 40 · see citing works

Anti-inflammatory effects of probiotics and synbiotics on patients with non-alcoholic fatty liver disease: An umbrella study on meta-analyses

Mahapatro, A., Bawna, F., Kumar, V., Daryagasht, A. A., Gupta, S., Raghuma, N., Moghdam, S. S., Kolla, A., Mahapatra, S. S., Sattari, N., et al. (2023) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2023.07.087 · Cited by 37 · see citing works

Mucosal epithelial barrier repair to maintain pig health

Blikslager, A. T. (2010) · Livestock Science · doi:10.1016/j.livsci.2010.06.062 · Cited by 18 · see citing works

Claudins of intestine and nephron – a correlation of molecular tight junction structure and barrier function

Amasheh, S., Fromm, M., & Günzel, D. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02148.x · Cited by 156 · see citing works

Loss of NKCC1 function increases epithelial tight junction permeability by upregulating claudin-2 expression

Koumangoye, R. B., Penny, P., & Delpire, E. J. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00334.2022 · Cited by 14 · see citing works

Bin1 Attenuation Suppresses Experimental Colitis by Enforcing Intestinal Barrier Function

Chang, M. Y., Boulden, J., Valenzano, M. C., Soler, A. P., Muller, A. J., Mullin, J. M., & Prendergast, G. C. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2147-y · Cited by 18 · see citing works

Sublethal hypoxic injury increases intestinal permeability via disruption of sealing tight junction proteins, but not pore forming tight junction proteins in human intestinal epithelium

Jin, Y., & Blikslager, A. T. (2013) · The FASEB Journal · doi:10.1096/fasebj.27.1_supplement.650.11