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Cited by 760

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Increased Intestinal Permeability in Patients with Crohn's Disease and Their Relatives: A Possible Etiologic Factor

HOLLANDER, DANIEL, VADHEIM, CONSTANCE M., BRETTHOLZ, EDWARD, PETERSEN, GLORIA M., DELAHUNTY, THOMAS, ROTTER, JEROME I.·1986·Annals of Internal Medicine
DOI 10.7326/0003-4819-105-6-883
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Abstract

The cause of Crohn's disease is unknown, although alterations in intestinal permeability may play a primary role. Because we were interested in permeability changes that occur before the onset of intestinal inflammation, we took advantage of the known genetic predisposition to this disease and studied not only patients with Crohn's disease, but their clinically unaffected relatives as well. Intestinal permeability was assessed using the marker polyethylene glycol-400 ingested with a standard meal. We found that 17 normal volunteers absorbed 215 +/- 29.6 mg (mean +/- SE), whereas 11 patients with Crohn's disease absorbed 514 +/- 94.7 mg and their 32 healthy relatives absorbed 566 +/- 62.4 mg. The twofold increase in permeability of patients and their relatives (p less than 0.005 compared with controls) indicates that the intestinal defect in the ability to exclude larger sized molecules is not secondary to clinically recognized intestinal inflammation, but is a primary defect that may be an etiologic factor in this disease.

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Metadata

Authors
HOLLANDER, D., VADHEIM, C. M., BRETTHOLZ, E., PETERSEN, G. M., DELAHUNTY, T., & ROTTER, J. I.
Venue
Annals of Internal Medicine
Publisher
American College of Physicians
Published
1986-12-01
Volume
105
Issue
6
Pages
883-885
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
DOI
10.7326/0003-4819-105-6-883
OpenAlex
W2077198680
Cited by
760
References
11
FWCI
8.09
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Increased Intestinal Permeability in Patients with Crohn's Disease and Their Relatives: A Possible Etiologic Factor. https://app.cochat.ai/papers/10.7326/0003-4819-105-6-883
The paper
HOLLANDER, D., VADHEIM, C. M., BRETTHOLZ, E., PETERSEN, G. M., DELAHUNTY, T., & ROTTER, J. I. (1986). Increased Intestinal Permeability in Patients with Crohn's Disease and Their Relatives: A Possible Etiologic Factor. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-105-6-883

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.