Causes of venous ulceration: a new hypothesis
Open accessAbstract
Previous hypotheses about the causes of venous ulceration are inconsistent with recently published data. In patients with chronic venous insufficiency the number of functioning capillary loops visible in the skin on microscopy fell after the legs had been dependent for 30 minutes. Another study had shown that leucocytes became trapped in the circulation in dependent legs. A new hypothesis linking these two findings proposes that the trapped white cells occlude the capillaries and result in ischaemia of the skin of the leg.
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In 1988, Coleridge-Smith observed leukocytes trapped in the venous microcirculation secondary to venous hypertension.
“In 1988, Coleridge-Smith observed leukocytes trapped in the venous microcirculation secondary to venous hypertension.”
From The Big Idea: Iron-Dependent Inflammation in Venous Disease and Proposed Parallels in Multiple Sclerosis (2006) · cites this paper as [10]
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- Authors
- Smith, P. D. C., Thomas, P., Scurr, J. H., & Dormandy, J. A.
- Affiliations
- St George's Hospital (GB)
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1988-06-18
- Volume
- 296
- Issue
- 6638
- Pages
- 1726-1727
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- PMC
- PMC2546102
- OpenAlex
- W2023526357
- Cited by
- 555
- References
- 8
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 7 · 2023: 8 · 2022: 9 · 2021: 4 · 2020: 4 · 2019: 9 · 2018: 7 · 2017: 11 · 2016: 14 · 2015: 15 · 2014: 15 · 2013: 9 · 2012: 16
- FWCI
- 17.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BMJ (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Diagnosis and Treatment of Venous Diseases
- Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Keywords
- venous ulceration, chronic venous insufficiency, capillary loops, pathogenesis
- MeSH terms
- Chronic Disease, Humans, Ischemia, Leukocytes, Regional Blood Flow, Skin, Varicose Ulcer, Venous Insufficiency
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