Cited by 255Statistical Methods in Clinical TrialsMeta-analysis and systematic reviewsStatistical Methods in Epidemiology

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When to stop a clinical trial.

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Pocock, S. J.·1992·BMJ

DOI 10.1136/bmj.305.6847.235PMC PMC1882707

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A Multiple Testing Procedure for Clinical Trials
O'Brien, P. C., & Fleming, T. R. (1979) · Biometrics · doi:10.2307/2530245 · Cited by 3,311
Equipoise and the Ethics of Clinical Research
Freedman, B. (1987) · New England Journal of Medicine · doi:10.1056/nejm198707163170304 · Cited by 2,339
Discrete sequential boundaries for clinical trials
GORDON LAN, K. K., & DEMETS, D. L. (1983) · Biometrika · doi:10.1093/biomet/70.3.659 · Cited by 2,310
Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design
Peto, R., Pike, M. C., Armitage, P., Breslow, N. E., Cox, D. R., Howard, S. V., Mantel, N., McPherson, K., Peto, J., & Smith, P. G. (1976) · British Journal of Cancer · doi:10.1038/bjc.1976.220 · Cited by 2,294
Zidovudine in Asymptomatic Human Immunodeficiency Virus Infection
Volberding, P. A., Lagakos, S. W., Koch, M. A., Pettinelli, C., Myers, M. W., Booth, D. K., Balfour, H. H., Reichman, R. C., Bartlett, J. A., Hirsch, M., et al. (1990) · New England Journal of Medicine · doi:10.1056/nejm199004053221401 · Cited by 1,285
A Randomized Trial of Induction Chemotherapy plus High-Dose Radiation versus Radiation Alone in Stage III Non-Small-Cell Lung Cancer
Dillman, R. O., Seagren, S. L., PROPERT, K. J., Guerra, J., Eaton, W. L., Perry, M. C., Carey, R. W., Frei, E., & Green, M. R. (1990) · New England Journal of Medicine · doi:10.1056/nejm199010043231403 · Cited by 1,151
Intravenous and intracoronary fibrinolytic therapy in acute myocardial infarction: Overview of results on mortality, reinfarction and side-effects from 33 randomized controlled trials
Yusuf, S., Collins, R., Peto, R., Furberg, C. D., Stampfer, M. J., Goldhaber, S. Z., & Hennekens, C. H. (1985) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a061905 · Cited by 568
Preliminary Report: Findings from the Aspirin Component of the Ongoing Physicians' Health Study
The Steering Committee of the Physicians' Health Study Research Group (1988) · New England Journal of Medicine · doi:10.1056/nejm198801283180431 · Cited by 522
Extracorporeal Membrane Oxygenation and Conventional Medical Therapy in Neonates With Persistent Pulmonary Hypertension of the Newborn: A Prospective Randomized Study
O’Rourke, P. P., Crone, R. K., Vacanti, J. P., Ware, J. H., Lillehei, C. W., Parad, R. B., & Epstein, M. F. (1989) · PEDIATRICS · doi:10.1542/peds.84.6.957 · Cited by 493
Designs for group sequential tests
Fleming, T. R., Harrington, D. P., & O’Brien, P. C. (1984) · Controlled Clinical Trials · doi:10.1016/s0197-2456(84)80014-8 · Cited by 354

Show all 21 references

Research works printed but not linked: 11

Freedman B. Equilx)ise and the ethics otf clinical rcscarch. N l.ngl J Med 1987;317:141-5.
Fleming rR, Harrington DP, O'Brien PaC. D)esigns for grouLp scqtuential tests. Controlled Clin 7rials 1984;5:348-61.
West of Scotland Coronary Plrevention Study (iroup. A coronary primary prevention stuvtvof 6000 Scottish men aged 45-64 ycars: studydcesign.7Clin Epidemiol (in press).
Souhami RL, Spiro SG, CLillen M. Chcmrothcrapv antd radiatioii thcralpy as compared with radiation therapy in stage III noni-snmall cc1l luIg calnccr. N Enmg1.ied 1991;324:1136.
Ilropert KI, D)illman RO, Seagrcen SL. Chemotherapy anid radiation therapy as comparcd with radiation therapy in stage IIIll ioi-sntall ccll luilg calnccr. NlEniV/M,cd 1991;324:1 136-7. 19 1Pocock Sj, Hughes Nil). P'ractical problems in intcrim analyses, with particuilar regard to estimation. Controlled Clinl lurials 1989;10:2209-15.
Cardiac Arrhythmia Stippression 'T'rial Investigators. Preliminary report: efiect of encainide atid flccainide oii mortality in a randimized trial of arrhythmia suppressioti after mnocardial infarction. N Etigl J Mted 1989;321:406-12.
Pocock SJ, Hughes MD. Estimation issues in cliical trials atid overviews. StatAed 1990;9:657-7 1.
Errington RD, Ashbv D, Gore SM, Abrams KR, Mivint S, Boiinett DE, et al. High energ) neutron treatment for pelvic cancers: study stopped becatise of incrcased mortality. RMJ 1991;302:10145-51.
Lan KK, Simon R, Halperin M. Stochastically curtailed sampling in longterm clinical trials. Communicatiots In Statistics-Theory and Methods 1984;13:2339-53.
ISIS Steering Committee. Intrasenous streptokinase given within 0-4 hours of onset of myocardial infarctiots rcduced mortality in ISIS-2. Lancet 1987;i:502.
Steering Committee of the Physicians' Health Study Research Group. Final report on the aspirin component of the ongoing physicians' health study. N Englj3Med 1989;321:129-35.

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CMAJ endorses the CONSORT statement. CONsolidation of Standards for Reporting Trials.
Huston, P., & Hoey, J. (1996) · Europe PMC (PubMed Central) · Cited by 21
The making of the clinical trial in Britain, 1910-1945 : expertise, the state and the public
Cox-Maksimov, D. (1997) · OpenGrey (Institut de l'Information Scientifique et Technique) · doi:10.17863/cam.19701 · Cited by 21
Exercise and depression in overweight and obese pregnant women: a randomised controlled trial
Perales, M., Rodríguez, Y. C., Vargas‐Terrones, M., Lucía, A., & Carballo, R. B. (2015) · Hispana · Cited by 20
Bioethics in Practice: Considerations for Stopping a Clinical Trial Early.
Deichmann, R. E., Krousel-Wood, M. A., & Breault, J. L. (2016) · PubMed Central · Cited by 20
Stopping clinical trials early
Grant, A. (2004) · BMJ · doi:10.1136/bmj.329.7465.525 · Cited by 20
Comparison of futility monitoring guidelines using completed phase III oncology trials
Zhang, Q., Freidlin, B., Korn, E. L., Halabi, S., Mandrekar, S. J., & Dignam, J. J. (2016) · Clinical Trials · doi:10.1177/1740774516666502 · Cited by 19
Randomized Trials Stopped Early for Harm in HIV/AIDS: A Systematic Survey
Mills, E. J., Cooper, C., Wu, P., Rachlis, B., Singh, S., & Guyatt, G. (2006) · HIV Clinical Trials · doi:10.1310/feed-6t8u-0bug-6hqh · Cited by 18
Mifepristone vs balloon catheter for labor induction in previous cesarean: a randomized controlled trial
Sharma, C., Soni, A., Gupta, A. K., Verma, A., & Verma, S. K. (2017) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-017-4431-8 · Cited by 18
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Interim Analyses: An Update of an FDA Reviewer’s Experience and Perspective
Sankoh, A. J. (1999) · Drug Information Journal · doi:10.1177/009286159903300120 · Cited by 17
Some Popular Versions of Uninformed Consent
Hutton, J. L., & Ashcroft, R. E. (2000) · Health Care Analysis · doi:10.1023/a:1009421824028 · Cited by 17
Continuous safety monitoring for randomized controlled clinical trials with blinded treatment information
Ball, G., & Piller, L. B. (2011) · Contemporary Clinical Trials · doi:10.1016/j.cct.2011.05.009 · Cited by 16
Interim analyses and stopping rules in cancer clinical trials
Whitehead, J. (1993) · British Journal of Cancer · doi:10.1038/bjc.1993.500 · Cited by 16
Publishing interim results of randomised clinical trials in peer-reviewed journals
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Ellenberg, S. S. (2012) · PLoS Medicine · doi:10.1371/journal.pmed.1001234 · Cited by 15
Erythropoietin to treat anaemia in patients with head and neck cancer
Freidlin, B., & Korn, E. L. (2004) · The Lancet · doi:10.1016/s0140-6736(03)15187-2 · Cited by 15
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Hill, A. M., Pauls, R. N., Basil, J., Tam, T., Yook, E., Shatkin-Margolis, A., Kleeman, S., Yeung, J., Aldrich, E., & Crisp, C. C. (2021) · Urogynecology · doi:10.1097/spv.0000000000001066 · Cited by 13
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Moore, T., & Clayton, R. (2012) · Lecture notes in computer science · doi:10.1007/978-3-642-29889-9_14 · Cited by 13
Double-blind, randomized trial of cessation of smoking after audiotape suggestion during anaesthesia
Myles, P. S., Hendrata, M., LAYHER, Y., Williams, N. J., Hall, J. L., Moloney, J., & Powell, J. (1996) · British Journal of Anaesthesia · doi:10.1093/bja/76.5.694 · Cited by 13
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Gafos, M., Mzimela, M. A., Ndlovu, H. B., Mhlongo, N., Hoogland, Y., & Mutemwa, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014577 · Cited by 12
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Largent, E. A., Walter, S., Childs, N., Dacks, P. A., Dodge, S. G., Florian, H., Jackson, J., Guerra, J. J. L., Iturriaga, E., Miller, D. S., et al. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12732 · Cited by 12
How reliable are clinical trials?: The importance of the criteria for early termination
Schwartz, P. J. (1995) · European Heart Journal · doi:10.1093/eurheartj/16.suppl_g.37 · Cited by 12
Issues in clinical trial design: Stopping a trial early and the large and simple trial
Thom, E. A., & Klebanoff, M. A. (2005) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.05.061 · Cited by 12
Outcome-adaptive randomization in clinical trials: issues of participant welfare and autonomy
Sim, J. (2019) · Metamedicine · doi:10.1007/s11017-019-09481-0 · Cited by 11
Misoprostol for Labour Induction after Previous Caesarean Section – Forever a “No Go”?
Rath, W. H., & Tsikouras, P. N. (2015) · Geburtshilfe und Frauenheilkunde · doi:10.1055/s-0035-1558171 · Cited by 10
Review article: Role of magnesium sulphate in the management of Irukandji syndrome: A systematic review
Rathbone, J., Franklin, R. C., Gibbs, C. R., & Williams, D. J. (2016) · Emergency Medicine Australasia · doi:10.1111/1742-6723.12694 · Cited by 10
Is structural hydroxyapatite tricalcium-phosphate graft or tricortical iliac crest autograft better for calcaneal lengthening osteotomy in childhood?
Martinkevich, P., Rahbek, O., Stilling, M., Pedersen, L. K., Gottliebsen, M., Søballé, K., & Møller‐Madsen, B. (2016) · The Bone & Joint Journal · doi:10.1302/0301-620x.98b11.bjj-2016-0095.r1 · Cited by 10
Ethical Issues Arising When Interim Data in Clinical Trials Is Restricted to Independent Data Monitoring Committees
Wells, R. J., Gartside, P. S., & McHenry, C. L. (2000) · IRB Ethics and Human Research · doi:10.2307/3564196 · Cited by 10
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Wildschut, H. I. J., Duvekot, J. J., Cook, J. R., Bacchus, L. J., Bewley, S., Creighton, S., Dear, J., Williams, D., Kilby, M. D., Crouch, N. S., et al. (2017) · Cambridge University Press eBooks · doi:10.1017/9781108349185 · Cited by 11
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Sarkar, S., Dechert, R. E., Becker, M. A., Attar, M. A., Schumacher, R. E., & Donn, S. M. (2008) · Journal of Neonatal-Perinatal Medicine · doi:10.3233/npm-2008-00003 · Cited by 9
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Korn, E. L., & Freidlin, B. (2006) · Biometrical Journal · doi:10.1002/bimj.200510216 · Cited by 9
[Statistical design in clinical trials].
Rubio‐Terres, C. (1996) · PubMed · Cited by 9
Evaluation of arthroscopic treatment of posterior shoulder instability
Garcia, J. C., Maia, L. R., Fonseca, J. R., Zabeu, J. L. A., & Garcia, J. P. M. (2015) · Acta Ortopédica Brasileira · doi:10.1590/1413-78522015230300540 · Cited by 9
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Ethical Dilemmas and Malfunctions in Clinical Trials Research
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Self-citation
Monitoring randomised controlled trials
Abrams, K. R. (1998) · BMJ · doi:10.1136/bmj.316.7139.1183 · Cited by 9
Hypertonic saline infusion does not improve the chance of primary fascial closure after damage control laparotomy: a randomized controlled trial
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Mukherjee, S. D., Goffin, J. R., Taylor, V. H., Anderson, K. K., & Pond, G. R. (2011) · European Journal of Cancer · doi:10.1016/j.ejca.2011.05.019 · Cited by 8
Is it ethical to keep interim findings of randomised controlled trials confidential?: Table 1
Miller, F. G., & Wendler, D. S. (2008) · Journal of Medical Ethics · doi:10.1136/jme.2006.019109 · Cited by 8
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Lakens, D. (2017) · doi:10.31234/osf.io/9yegd · Cited by 8
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Hennekens, C. H., & DeMets, D. L. (2011) · Clinical Investigation · doi:10.4155/cli.10.11 · Cited by 7
Excessive Perioperative Bleeding
Spahn, D. R., & Asmis, L. M. (2009) · Anesthesiology · doi:10.1097/aln.0b013e3181942c65 · Cited by 7
“Questioning” the truth effect: Processing information in interrogative form reduces (but does not cancel) repetition-induced truth
Mattavelli, S., Bianchi, C., & Motterlini, M. (2025) · Memory & Cognition · doi:10.3758/s13421-025-01742-9 · Cited by 5
I. Stopping trials early
Myles, P. S. (2013) · British Journal of Anaesthesia · doi:10.1093/bja/aet079 · Cited by 6
Stopping rules in veterinary randomized controlled trials
Habing, G. G., & Kaneene, J. B. (2011) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.239.9.1197 · Cited by 6
Evidence-Based Medicine - A Paradigm Ready To Be Challenged?
Schulte, M.-C. (2020) · J.B. Metzler eBooks · doi:10.1007/978-3-476-05703-7 · Cited by 6
Analysis and presentation
Friberg, S. G., Taube, A., Sylvester, R. J., & Oesterling, J. E. (1997) · Urology · doi:10.1016/s0090-4295(99)80324-0 · Cited by 6
Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis
Warner, E., Plewes, D., Hill, K., Causer, P., Zubovits, J., Jong, R., Cutrara, M., Deboer, G., Yaffe, M., Messner, S. J., et al. (2004) · British medical journal · doi:10.1097/01.aog.0000148205.12276.8b · Cited by 2,631
Monitoring Response Variables
Friedman, L. M., Furberg, C. D., & DeMets, D. L. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1586-3_16 · Cited by 6
Interim Analyses: An FDA Reviewer's Experience and Perspective
Sankoh, A. J. (1995) · Drug Information Journal · doi:10.1177/009286159502900252 · Cited by 6
When to stop a clinical trial.
Neale, E. (1992) · BMJ · doi:10.1136/bmj.305.6851.475 · Cited by 6
Decision making in clinical trials: Interim analyses, innovative design, and biomarkers
Welsh-Bohmer, K. A., Kerchner, G. A., Dhadda, S., Garcia, M., Miller, D. S., Natanegara, F., Rakêt, L. L., Robieson, W., Siemers, E., Carrillo, M. C., et al. (2023) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12421 · Cited by 4
Clinical Research in Obstetrics and Gynecology: More Tips for Busy Clinicians
Grimes, D. A., & Schulz, K. F. (2005) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000176675.60585.63 · Cited by 5
Comment on “Adjuvant Therapy in Pancreatic Cancer: A Critical Appraisal”
Ghaneh, P., Smith, C. T., & Neoptolemos, J. P. (2007) · Drugs · doi:10.2165/00003495-200767170-00002 · Cited by 5
Improving the treatment of severe acute malnutrition in childhood: a randomized controlled trial of synbiotic-enhanced therapeutic food with long term follow-up of post-treatment mortality and morbidity
Kerac, M. (2011) · UCL Discovery (University College London) · Cited by 5
Perioperative blood loss reduction using a sterile exsanguination tourniquet for orthopedic femoral-related surgeries in children: a randomized controlled study
Rattanathanya, T., Adulkasem, N., Wongcharoenwatana, J., Ariyawatkul, T., Chotigavanichaya, C., & Eamsobhana, P. (2023) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-023-04046-3 · Cited by 4
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Statistical analysis plan for the Prophylactic Melatonin for Delirium in Intensive Care (ProMEDIC): a randomised controlled trial
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Data Safety and Monitoring Boards (DSMBs)
Glasser, S. P., & Williams, O. D. (2014) · Springer eBooks · doi:10.1007/978-3-319-05470-4_9 · Cited by 4
Causal Criteria in Medical and Biological Disciplines: History, Essence, and Radiation Aspect. Report 3, Part 2: Hill’s Last Four Criteria: Use and Limitations
Koterov, A. N. (2022) · Biology Bulletin · doi:10.1134/s1062359022110115 · Cited by 4
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Wilkinson, D. J. C. (2010) · Journal of Paediatrics and Child Health · doi:10.1111/j.1440-1754.2010.01864.x · Cited by 4
Comparison of two regimens of a monthly injectable contraceptive containing dihydroxyprogesterone acetophenide and estradiol enanthate
Coutinho, E. M., Spinola, P. G., Athayde, C., Noronha, C. F., de Melo, N. R., Cabral, Z. A. F., Almeida, J. A. M., da Silva, B. L., Neto, J. S. P., & Rumi, D. O. (2005) · Contraception · doi:10.1016/j.contraception.2005.08.016 · Cited by 4
Perspectives on the Womenʼs Health Initiative Trial of Hormone Replacement Therapy
Grimes, D. A., & Løbo, R. A. (2002) · Obstetrics and Gynecology · doi:10.1097/00006250-200212000-00029 · Cited by 4
Monitoring Randomized Clinical Trials
Leifer, E., & Geller, N. L. (2012) · Wiley series in probability and statistics · doi:10.1002/9781118147634.ch6 · Cited by 4
Families’ experiences with medical research for pediatric rare diseases : a qualitative ethnographic study of parents and children participating in clinical trials for Duchenne muscular dystrophy (DMD)
Condin, C. J. (2014) · cIRcle (University of British Columbia) · doi:10.14288/1.0135585 · Cited by 4
Reporting of clinical trials using group sequential methods
Moran, J. L., Peake, S., & Solomon, P. (2001) · Critical Care and Resuscitation · doi:10.1016/s1441-2772(23)00605-1 · Cited by 4
Development and Evaluation of a Simulation-Based Algorithm to Optimize the Planning of Interim Analyses for Clinical Trials in ALS
van Unnik, J. W. J., Nikolakopoulos, S., Eijkemans, M. J. C., Gonzalez‐Bermejo, J., Bruneteau, G., Morélot‐Panzini, C., van den Berg, L. H., Cudkowicz, M., McDermott, C. J., Similowski, T., et al. (2023) · Neurology · doi:10.1212/wnl.0000000000207306 · Cited by 3
Induction of Labor and Termination of the Previable Pregnancy
Sanchez‐Ramos, L., & Delke, I. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4160-5908-0.00066-1 · Cited by 3
Can we trust in trials stopped early for benefit?
(GrAM), G. D. A. M., Casazza, G., & Casella, F. (2012) · Internal and Emergency Medicine · doi:10.1007/s11739-012-0871-0 · Cited by 3
Three-stage designs for monitoring clinical trials
Case, L. D., Morgan, T. M., & DAVIS, C. E. (1994) · Communication in Statistics- Theory and Methods · doi:10.1080/03610929408831362 · Cited by 3
Patients as subjects for research: ethical dilemmas for the primary care clinician-investigator.
Slatkoff, S. F., Curtis, P., & Coker, A. L. (1994) · PubMed · Cited by 3
Should Clinical Trials Be Terminated Early?
Streiner, D. L. (2019) · Clinical Therapeutics · doi:10.1016/j.clinthera.2019.07.004 · Cited by 3
Implementation of a Data and Safety Monitoring Program in a General Clinical Research Center
Brass, E. P. (2001) · Journal of Investigative Medicine · doi:10.2310/6650.2001.33623 · Cited by 3
Bristow artroscópico: Avaliação da segurança e da eficácia, 12 anos de experiência
Garcia, J. C. (2019) · Revista Brasileira de Ortopedia · doi:10.1055/s-0039-1697972 · Cited by 2
Ensayos clínicos aleatorizados
Cobos, A. (2010) · Elsevier eBooks · doi:10.1016/b978-84-8086-461-9.50013-8 · Cited by 2
Interim analysis in randomized trials: DAMOCLES' sword?
Besselink, M. G., van der Graaf, Y., & Gooszen, H. G. (2009) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2009.07.004 · Cited by 2
Treating Clostridium difficile infections: Should fecal microbiota transplantation be reclassified from investigational drug to human tissue?
Stuntz, M., & Vignes, F. D. (2015) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2015.11.001 · Cited by 2
Health technology assessment teaching for BME
Pecchia, L., Piaggio, D., Pallikarakis, N. E., & Iadanza, E. (2019) · Clinical Engineering Handbook · doi:10.1016/b978-0-12-813467-2.00119-x · Cited by 2
Discovering treatment effectiveness via median treatment effects—Applications to COVID‐19 clinical trials
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Stopping Trials Early: Responsibility and Risks
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Authors: Pocock, S. J.
Affiliations: London School of Hygiene & Tropical Medicine (GB)
Corresponding author: Pocock, S. J.
ORCID: Pocock, S. J.
Venue: BMJ
Publisher: BMJ
Published: 1992-07-25
Volume: 305
Issue: 6847
Pages: 235-240
ISSN: 0007-1447 (ISSN-L)
0959-8138
1468-5833
DOI: 10.1136/bmj.305.6847.235
PMC: PMC1882707
OpenAlex: W1968817382
Cited by: 255
References: 21
Citations by year: 2025: 2 · 2024: 1 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 3 · 2019: 10 · 2018: 4 · 2017: 6 · 2016: 12 · 2015: 10 · 2014: 20 · 2013: 8 · 2012: 12
FWCI: 10.53
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: BMJ (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
DigitalGeorgetown (Georgetown University Library) (submittedVersion)
Topics: Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
Keywords: clinical trial termination, stopping rules, trial ethics
MeSH terms: Clinical Trials as Topic, Data Interpretation, Statistical, Decision Making, Ethics, Medical, Risk Assessment, Information Dissemination, Editorial Policies, Uncertainty, Therapeutic Human Experimentation

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