The scandal of poor medical research.

Withdrawal of Digoxin from Patients with Chronic Heart Failure Treated with Angiotensin-Converting-Enzyme Inhibitors

Packer, M., Gheorghiade, M., Young, J. B., Costantini, P. J., Adams, K. F., Cody, R. J., Smith, L. K., Voorhees, L. V., Gourley, L. A., & Jolly, M. (1993) · New England Journal of Medicine · doi:10.1056/nejm199307013290101 · Cited by 826 · see citing works

Statistical Problems in the Reporting of Clinical Trials

Pocock, S., Hughes, M. D., & Lee, R. J. (1987) · New England Journal of Medicine · doi:10.1056/nejm198708133170706 · Cited by 660 · see citing works

Methodology and overt and hidden bias in reports of 196 double-blind trials of nonsteroidal antiinflammatory drugs in rheumatoid arthritis

Gøtzsche, P. C. (1989) · Controlled Clinical Trials · doi:10.1016/0197-2456(89)90017-2 · Cited by 339 · see citing works

Statistics in medical journals

Altman, D. G. (1982) · Statistics in Medicine · doi:10.1002/sim.4780010109 · Cited by 227 · see citing works

Statistics and ethics in medical research. Misuse of statistics is unethical.

Altman, D. G. (1980) · BMJ · doi:10.1136/bmj.281.6249.1182 · Cited by 132 · see citing works

Impact of multiple comparisons in randomized clinical trials

Smith, D. G., Clemens, J. D., Credè, W. B., Harvey, M., & Gracely, E. J. (1987) · The American Journal of Medicine · doi:10.1016/0002-9343(87)90768-6 · Cited by 88 · see citing works

Reflections on the Decline of Science in England (1830)

Babbage, C. (2024) · Routledge eBooks · doi:10.4324/9781003548249-13 · Cited by 76 · see citing works

Inadequate size of 'negative' clinical trials in dermatology

Williams, H. C., & Seed, P. T. (1993) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1993.tb00178.x · Cited by 67 · see citing works

The task of a statistical referee

Murray, G. D. (1988) · British journal of surgery · doi:10.1002/bjs.1800750714 · Cited by 64 · see citing works

Methodological errors in Medical Research

Huxtable, R. J. (1991) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(91)90504-l · Cited by 39 · see citing works

Screening for congenital hypothyroidism

Fisher, D. A. (1991) · Trends in Endocrinology and Metabolism · doi:10.1016/1043-2760(91)90002-5 · Cited by 36 · see citing works

Methodological Errors in Medical Research. An Incomplete Catalogue

(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-7-608_1 · Cited by 25 · see citing works

Bailar's laws of data analysis

Bailar, J. C. (1976) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1976201113 · Cited by 19 · see citing works

Statisticians in Medical Schools

Bland, J. M., Altman, D. G., & Royston, J. P. (1990) · Journal of the Royal College of Physicians of London · doi:10.1016/s0035-8819(25)02119-1 · Cited by 12 · see citing works

Therapeutics and government: 1776 and 1976

Abrams, W. B. (1976) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt19762011 · Cited by 3 · see citing works

Bias in meta-analysis detected by a simple, graphical test

Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722 · see citing works

CONSORT 2010 Explanation and Elaboration: updated guidelines for reporting parallel group randomised trials

Moher, D., Hopewell, S., Schulz, K. F., Montori, V., Gotzsche, P. C., Devereaux, P. J., Elbourne, D., Egger, M., & Altman, D. G. (2010) · BMJ · doi:10.1136/bmj.c869 · Cited by 8,883 · see citing works

The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials

Moher, D., Schulz, K. F., & Altman, D. G. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04337-3 · Cited by 5,373 · see citing works

The Revised CONSORT Statement for Reporting Randomized Trials: Explanation and Elaboration

Altman, D. G., Schulz, K. F., Moher, D., Egger, M., Davidoff, F., Elbourne, D., Gøtzsche, P. C., Lang, T., & for the CONSORT Group (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-8-200104170-00012 · Cited by 3,835 · see citing works

Improving the Quality of Reporting of Randomized Controlled Trials: The CONSORT Statement

Begg, C. (1996) · JAMA · doi:10.1001/jama.1996.03540080059030 · Cited by 3,127 · see citing works

The CONSORT statement: revised recommendations for improving the quality of reports of parallel group randomized trials

Moher, D., Schulz, K. F., & Altman, D. G. (2001) · BMC Medical Research Methodology · doi:10.1186/1471-2288-1-2 · Cited by 2,755 · see citing works

The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials

Moher, D. (2001) · JAMA · doi:10.1001/jama.285.15.1987 · Cited by 2,545 · see citing works

CONSORT 2010 explanation and elaboration: Updated guidelines for reporting parallel group randomised trials

Moher, D., Hopewell, S., Schulz, K. F., Montori, V., Gøtzsche, P. C., Devereaux, P. J., Elbourne, D., Egger, M., & Altman, D. G. (2012) · International Journal of Surgery · doi:10.1016/j.ijsu.2011.10.001 · Cited by 2,345 · see citing works

CONSORT 2010 Explanation and Elaboration: Updated guidelines for reporting parallel group randomised trials

Moher, D., Hopewell, S., Schulz, K. F., Montori, V., Gøtzsche, P. C., Devereaux, P. J., Elbourne, D., Egger, M., & Altman, D. G. (2010) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.03.004 · Cited by 1,858 · see citing works

Increasing value and reducing waste in research design, conduct, and analysis

Ioannidis, J. P. A., Greenland, S., Hlatky, M. A., Khoury, M. J., Macleod, M. R., Moher, D., Schulz, K. F., & Tibshirani, R. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62227-8 · Cited by 1,597 · see citing works

How to increase value and reduce waste when research priorities are set

Chalmers, I., Bracken, M. B., Djulbegovic, B., Garattini, S., Grant, J., Gülmezoglu, A. M., Howells, D. W., Ioannidis, J. P. A., & Oliver, S. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62229-1 · Cited by 1,436 · see citing works

The CONSORT Statement: Revised Recommendations for Improving the Quality of Reports of Parallel-Group Randomized Trials

Moher, D., Schulz, K. F., Altman, D. G., & for the CONSORT Group* (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-8-200104170-00011 · Cited by 1,426 · see citing works

Progress in evidence-based medicine: a quarter century on

Djulbegovic, B., & Guyatt, G. H. (2017) · The Lancet · doi:10.1016/s0140-6736(16)31592-6 · Cited by 1,022 · see citing works

The impact of study size on meta-analyses: examination of underpowered studies in Cochrane reviews

Turner, R. M., Bird, S. M., & Higgins, J. P. T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059202 · Cited by 672 · see citing works

The problem of pseudoreplication in neuroscientific studies: is it affecting your analysis?

Lazic, S. E. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-5 · Cited by 381 · see citing works

Guidelines for Reporting Trial Protocols and Completed Trials Modified Due to the COVID-19 Pandemic and Other Extenuating Circumstances: The CONSERVE 2021 Statement

Orkin, A. M., Gill, P. J., Ghersi, D., Campbell, L., Sugarman, J., Emsley, R., Steg, P. G., Weijer, C., Simes, J., Rombey, T., et al. (2021) · JAMA · doi:10.1001/jama.2021.9941 · Cited by 299 · see citing works

Effect of using reporting guidelines during peer review on quality of final manuscripts submitted to a biomedical journal: masked randomised trial

Cobo, E., Cortes, J., Ribera, J. M., Cardellach, F., Selva-O'Callaghan, A., Kostov, B., Garcia, L., Cirugeda, L., Altman, D. G., Gonzalez, J. A., et al. (2011) · BMJ · doi:10.1136/bmj.d6783 · Cited by 290 · see citing works

False Alarms and Pseudo-Epidemics: The Limitations of Observational Epidemiology

Grimes, D. A., & Schulz, K. F. (2012) · Obstetrics & Gynecology · doi:10.1097/aog.0b013e31826af61a · Cited by 254 · see citing works

What errors do peer reviewers detect, and does training improve their ability to detect them?

Schroter, S., Black, N., Evans, S., Godlee, F., Osorio, L., & Smith, R. (2008) · Journal of the Royal Society of Medicine · doi:10.1258/jrsm.2008.080062 · Cited by 226 · see citing works

Are Peer Reviewers Encouraged to Use Reporting Guidelines? A Survey of 116 Health Research Journals

Hirst, A., & Altman, D. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035621 · Cited by 200 · see citing works

The CONSORT statement: revised recommendations for improving the quality of reports of parallel group randomized trials

Moher, D., Schulz, K. F., & Altman, D. G. (2001) · Journal of the American Podiatric Medical Association · doi:10.7547/87507315-91-8-437 · Cited by 193 · see citing works

Incongruence between test statistics and P values in medical papers

García-Berthou, E., & Alcaraz, C. (2004) · BMC Medical Research Methodology · doi:10.1186/1471-2288-4-13 · Cited by 181 · see citing works

Methodology over metrics: current scientific standards are a disservice to patients and society

Van Calster, B., Wynants, L., Riley, R. D., van Smeden, M., & Collins, G. S. (2021) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2021.05.018 · Cited by 105 · see citing works

Sources of error in the retracted scientific literature

Casadevall, A., Steen, R. G., & Fang, F. C. (2014) · The FASEB Journal · doi:10.1096/fj.14-256735 · Cited by 89 · see citing works

Effect of Removing Outliers on Statistical Inference: Implications to Interpretation of Experimental Data in Medical Research

Marshall University, Gress, T. W., Denvir, J., Marshall University, Shapiro, J. I., & Marshall University (2018) · Marshall Journal of Medicine · doi:10.18590/mjm.2018.vol4.iss2.9 · Cited by 60 · see citing works

Protect us from poor-quality medical research

ESHRE Capri Workshop Group, Ioannidis, J. P. A., Bhattacharya, S., Evers, J. L. H., der Veen, F. V., Somigliana, E., Barratt, C. L. R., Bontempi, G., Baird, D. T., Crosignani, P., et al. (2018) · Human Reproduction · doi:10.1093/humrep/dey056 · Cited by 59 · see citing works

Evidence synthesis for tackling research waste

Grainger, M. J., Bolam, F. C., Stewart, G. B., & Nilsen, E. B. (2020) · Nature Ecology & Evolution · doi:10.1038/s41559-020-1141-6 · Cited by 59 · see citing works

Combining Animal Welfare With Experimental Rigor to Improve Reproducibility in Behavioral Neuroscience.

Loss, C. M., Melleu, F. F., Domingues, K., Lino-de-Oliveira, C., & Viola, G. G. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.763428 · Cited by 44 · see citing works

“Case-Control” Confusion: Mislabeled Reports in Obstetrics and Gynecology Journals

Grimes, D. A. (2009) · Obstetrics & Gynecology · doi:10.1097/aog.0b013e3181c03421 · Cited by 33 · see citing works

Why statistical inference from clinical trials is likely to generate false and irreproducible results

Hanin, L. (2017) · BMC Medical Research Methodology · doi:10.1186/s12874-017-0399-0 · Cited by 32 · see citing works

Evidence appraisal: a scoping review, conceptual framework, and research agenda

Goldstein, A., Venker, E., & Weng, C. (2017) · Journal of the American Medical Informatics Association · doi:10.1093/jamia/ocx050 · Cited by 30 · see citing works

Increase value and reduce waste in research on psychological therapies

Cristea, I. A., & Naudet, F. (2019) · Behaviour Research and Therapy · doi:10.1016/j.brat.2019.103479 · Cited by 22 · see citing works

Data extraction methods: an analysis of internal reporting discrepancies in single manuscripts and practical advice

Puljak, L., Riva, N., Parmelli, E., González-Lorenzo, M., Moja, L., & Pieper, D. (2020) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2019.09.003 · Cited by 16 · see citing works

Research transparency in dental research: A programmatic analysis

Raittio, E., Sofi‐Mahmudi, A., & Uribe, S. E. (2023) · European Journal of Oral Sciences · doi:10.1111/eos.12908 · Cited by 15 · see citing works

Up Front and Open? Shrouded in Secrecy? Or Somewhere in Between? A Meta-Research Systematic Review of Open Science Practices in Sport Medicine Research

Bullock, G. S., Ward, P., Impellizzeri, F. M., Kluzek, S., Hughes, T., Hillman, C., Waterman, B. R., Danelson, K., Henry, K., Barr, E., et al. (2023) · Journal of Orthopaedic & Sports Physical Therapy · doi:10.2519/jospt.2023.12016 · Cited by 15 · see citing works

CONSORT statement adherence and risk of bias in randomized controlled trials on deep caries management: a meta-research

Elagami, R. A., Reis, T. M., Hassan, M. A., Tedesco, T. K., Braga, M. M., Mendes, F. M., Cenci, M. S., Huysmans, M.-C., & Raggio, D. P. (2024) · BMC Oral Health · doi:10.1186/s12903-024-04417-0 · Cited by 14 · see citing works

GPT for RCTs?: Using AI to determine adherence to reporting guidelines

Wrightson, J. G., Blazey, P., Moher, D., Khan, K. M., & Ardern, C. L. (2023) · doi:10.1101/2023.12.14.23299971 · Cited by 24 · see citing works

Scientific integrity and the market for lemons

Cottrell, R. C. (2014) · Research Ethics · doi:10.1177/1747016113494651 · Cited by 6 · see citing works

Halal Food Logistics: The Challenges among Food & Beverages Small and Medium Sizes Manufacturers

Mahidin, N., & Saifudin, A. M. (2017) · Universiti Utara Malaysia Institutional Repository (Universiti Utara Malaysia) · Cited by 15 · see citing works

Driving In-Role and Extra-Role Brand Performance among Retail Frontline Salespeople: Antecedents and the Moderating Role of Customer Orientation

Hughes, D. E., Richards, K. A., Calantone, R. J., Baldus, B. J., & Spreng, R. A. (2019) · Journal of Retailing · doi:10.1016/j.jretai.2019.03.003 · Cited by 74 · see citing works

Determinant factors towards the adoption of halal logistics services among Malaysian halal Small Medium Enterprises (SMES)

Husny, Z. J., Hussein, M., & Tan, M. (2016) · Research Journal of Applied Sciences · Cited by 1 · see citing works

Impact of halal supplier service quality and staff readiness to adopt halal technology on halal logistics performance: a study of Indonesian halal meat supply chain

Masudin, I., Jie, F., & Widayat, N. A. (2020) · International Journal of Agile Systems and Management · doi:10.1504/ijasm.2020.109258 · Cited by 26 · see citing works

Impact of halal supplier service quality and staff readiness to adopt halal technology on halal logistics performance: a study of Indonesian halal meat supply chain

Widayat, W., Masudin, I., & Jie, F. (2020) · International Journal of Agile Systems and Management · doi:10.1504/ijasm.2020.10031513 · Cited by 6 · see citing works