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Cited by 484Diabetes Management and ResearchDiabetes, Cardiovascular Risks, and LipoproteinsChronic Kidney Disease and Diabetes

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Comparison of tests for glycated haemoglobin and fasting and two hour plasma glucose concentrations as diagnostic methods for diabetes

Open access
McCane, D R, Hanson, R L, Charles, M A, Jacobsson, L T H, Pettitt, D Dj, Bennett, P H, Knowler, W C·1994·BMJ
DOI 10.1136/bmj.308.6940.1323PMC PMC2540244
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Abstract

Objective : To compare the ability of tests measuring two hour plasma glucose, fasting plasma glucose, and glycated haemoglobin concentrations in predicting the specific microvascular complications of non-insulin dependent diabetes mellitus. Design : Cross sectional and longitudinal analysis of the relation between complications and concomitant results of the three tests. Setting : Gila River Indian Community, Arizona. Subjects : Pima Indians (cross sectional, n=960),aged 25 years or above who were not receiving insulin or oral hypoglycaemic treatment at the baseline examination. Main outcome measures : Development of retinopathy and nephropathy. Results : Cross sectionally, frequency distributions of logarithms of the three sets of results were bimodal, with the prevalence of retinopathy and nephropathy being, respectively, 12.0-26.7 and 3.9-4.2 times as high above as below cut off points which minimised overlap (two hour plasma glucose concentration 12.6 mmol/l; fasting plasma glucose concentration 9.3mmol/l; glycated haemoglobin (HbA1c) concentration 7.8%). Longitudinally, each of the three measures of glycaemia significantly predicted the development of retinopathy (P<0.0001) and nephropathy (P<0.05). Receiver operating characteristic curves showed that two hour plasma glucose concentration was superior to fasting plasma glucose concentration (P<0.05) for prevalent cases of retinopathy, but otherwise no variable had a significant advantage for detecting incident or prevalent cases of either complication. Conclusions : These findings suggest that determination of glycated haemoglobin or fasting plasma glucose concentrations alone may be acceptable alternatives to measuring glucose concentration two hours after challenge with 75 g glucose for the diagnosis of diabetes.

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Crossref · 10.1136/bmj.308.6940.1323

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47 of 47 references verified0 citation errors · 0 not checkable

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Citations

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Show all 45 references

Research works printed but not linked: 5

  1. John, 1922, Glucose tolerance and its value in diagnosis, Journal of Metabolic Research, 1, 497
  2. 1980, Second report, World Health Org Tech Rep Ser, 646, 9
  3. 1985, Diabetes mellitus, World Health Org Tech Rep Ser, 727, 9
  4. 10.2337/diab.18.5.299 · DOI
  5. 10.2337/diacare.12.8.588 · DOI

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Metadata

Authors
McCane, D. R., Hanson, R. L., Charles, M. A., Jacobsson, L. T. H., Pettitt, D. D., Bennett, P. H., & Knowler, W. C.
Affiliations
National Institute of Diabetes and Digestive and Kidney Diseases (US)
ORCID
Venue
BMJ
Publisher
BMJ
Published
1994-05-21
Volume
308
Issue
6940
Pages
1323-1328
ISSN
  • 0007-1447 (ISSN-L)
  • 0959-8138
  • 1468-5833
DOI
10.1136/bmj.308.6940.1323
PMC
PMC2540244
OpenAlex
W2054652204
Cited by
484
References
45
Citations by year
2026: 5 · 2025: 2 · 2024: 8 · 2023: 5 · 2022: 10 · 2021: 13 · 2020: 11 · 2019: 7 · 2018: 12 · 2017: 12 · 2016: 18 · 2015: 21 · 2014: 11 · 2013: 24 · 2012: 19
FWCI
5.86
Type
journal article
Language
en
Open access
Licence
www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy (tdm)
Locations
  • BMJ (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
Keywords
HbA1c, fasting blood glucose, diabetes diagnosis, type 2 diabetes, diabetic retinopathy, diabetic nephropathy, microvascular complications, Pima Indians, diagnostic test comparison
MeSH terms
Adult, Aged, Blood Glucose, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Diabetic Retinopathy, Fasting, Female, Glucose Tolerance Test, Glycated Hemoglobin, Humans, Indians, North American, Longitudinal Studies, Male, Middle Aged, Incidence, Prevalence

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