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Cited by 528Fibromyalgia and Chronic Fatigue Syndrome ResearchLong-Term Effects of COVID-19Musculoskeletal pain and rehabilitation

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Cognitive behaviour therapy for the chronic fatigue syndrome: a randomised controlled trial.

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Sharpe, Michael, Hawton, Keith, Simkin, Sue, Surawy, Christina, Hackmann, Ann, Klimes, Ivana, Peto, Tim, Warrell, David, Seagroatt, Valerie·1996·BMJ
DOI 10.1136/bmj.312.7022.22PMC PMC2349693
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Abstract

Abstract Objective : To evaluate the acceptability and efficacy of adding cognitive behaviour therapy to the medical care of patients presenting with the chronic fatigue syndrome. Design : Randomised controlled trial with final assessment at 12 months. Setting : An infectious diseases outpatient clinic. Subjects : 60 consecutively referred patients meeting consensus criteria for the chronic fatigue syndrome. Interventions : Medical care comprised assessment, advice, and follow up in general practice. Patients who received cognitive behaviour therapy were offered 16 individual weekly sessions in addition to their medical care. Main outcome measures : The proportions of patients (a) who achieved normal daily functioning (Karnofsky score 80 or more) and (b) who achieved a clinically significant improvement in functioning (change in Karnofsky score 10 points or more) by 12 months after randomisation. Results : Only two eligible patients refused to participate. All randomised patients completed treatment. An intention to treat analysis showed that 73% (22/30) of recipients of cognitive behaviour therapy achieved a satisfactory outcome as compared with 27% (8/30) of patients who were given only medical care (difference 47 percentage points; 95% confidence interval 24 to 69). Similar differences were observed in subsidiary outcome measures. The improvement in disability among patients given cognitive behaviour therapy continued after completion of therapy. Illness beliefs and coping behaviour previously associated with a poor outcome changed more with cognitive behaviour therapy than with medical care alone. Conclusion : Adding cognitive behaviour therapy to the medical care of patients with the chronic fatigue syndrome is acceptable to patients and leads to a sustained reduction in functional impairment. Key messages Key messages There is no generally accepted form of treatment New findings show that patients referred to hospital for the chronic fatigue syndrome have a better outcome if they are given a course of cognitive behaviour therapy than if they receive only basic medical care Clinical improvement with cognitive behaviour therapy may be slow but often continues after treatment has ended Cognitive behaviour therapy should be considered as an option for patients presenting with the chronic fatigue syndrome

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Research works printed but not linked: 6

  1. Sharpe MC . Chronic fatigue syndrome. Psychiatr Clin North Am (in press).
  2. Sharpe, 1995, Cognitive behaviour therapy and the treatment of chronic fatigue syndrome, Journal of Musculoskeletal Pain, 3, 141, 10.1300/J094v03n02_20 · DOI
  3. Beck AT Rush AJ Shaw BF Emery G . Cognitive therapy of depression New York: Guilford Press, 1979.
  4. 10.1002/1097-0142(194811)1:4<634::AID-CNCR2820010410>3.0.CO;2-L · DOI
  5. 10.1037/0022-006X.59.1.88 · DOI
  6. 10.1037/0022-006X.56.2.261 · DOI

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Metadata

Authors
Sharpe, M., Hawton, K., Simkin, S., Surawy, C., Hackmann, A., Klimes, I., Peto, T., Warrell, D., & Seagroatt, V.
Affiliations
  • Warneford Hospital (GB)
  • John Radcliffe Hospital (GB)
  • University of Oxford (GB)
ORCID
Venue
BMJ
Publisher
BMJ
Published
1996-01-06
Volume
312
Issue
7022
Pages
22-26
ISSN
  • 0007-1447 (ISSN-L)
  • 0959-8138
  • 1468-5833
DOI
10.1136/bmj.312.7022.22
PMC
PMC2349693
OpenAlex
W2023718291
Cited by
528
References
27
Citations by year
2026: 2 · 2025: 4 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 7 · 2019: 7 · 2018: 3 · 2017: 9 · 2016: 7 · 2015: 14 · 2014: 11 · 2013: 14 · 2012: 19
FWCI
47.30
Type
journal article
Language
en
Open access
Licence
www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy (tdm)
Locations
  • BMJ (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Funders
Wellcome Trust
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
  • Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
Keywords
chronic fatigue syndrome, cognitive behavioral therapy, health care, functional disability, Karnofsky performance status, illness beliefs, coping behaviour, treatment acceptability, treatment efficacy
MeSH terms
Adaptation, Psychological, Adult, Attitude to Health, Depression, Female, Humans, Male, Patient Compliance, Fatigue Syndrome, Chronic, Cognitive Behavioral Therapy, Treatment Outcome

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