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Cited by 168Cardiovascular Function and Risk FactorsCardiovascular Disease and AdiposityBariatric Surgery and Outcomes

Effects of obesity and weight loss on left ventricular mass and relative wall thickness: survey and intervention study

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Karason, K., Wallentin, I., Larsson, B., Sjostrom, L.·1997·BMJ
DOI 10.1136/bmj.315.7113.912PMC PMC2127625
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Abstract

Abstract Objectives: To investigate the consequences of longstanding obesity on left ventricular mass and structure and to examine the effects of weight loss on these variables. Design: Cross sectional survey and controlled intervention study. Setting: City of Gothenburg and surrounding areas, Sweden. Subjects: 41 obese patients treated with weight reducing gastric surgery, 31 obese patients treated conventionally, and 43 non-obese subjects. Main outcome measures: Changes in left ventricular mass and relative wall thickness. Results: Obese patients had higher blood pressure, greater left ventricular mass, and increased relative wall thickness than did matched non-obese control subjects. Obese subjects treated with gastric surgery had a substantial weight loss and a significant reduction in all variables when compared with conventionally treated obese subjects. Univariate and multivariate analysis of pooled data from the two groups of obese subjects showed that changes in relative wall thickness and left ventricular mass were more closely related to the change in weight than to the concomitant change in blood pressure. Conclusions: Structural heart abnormalities occurring in conjunction with obesity diminish after weight loss. The regression in these structural aberrations is better predicted by the weight loss than by the accompanying reduction in blood pressure. To prevent or improve abnormalities of heart structure in obese people, weight control should be the primary goal; it should be regarded as at least as important as regulating blood pressure. Key messages Obesity and hypertension often coexist, leading to various degrees of eccentric and concentric left ventricular hypertrophy These structural heart changes are in turn powerful risk factors for cardiovascular morbidity and mortality Weight loss is followed by a reduction in left ventricular mass and relative wall thickness Changes in left ventricular structure are better predicted by the weight loss than by the accompanying reduction in blood pressure To prevent or improve abnormal heart structure in obese people, weight control should be the primary goal and should be regarded as at least as important as regulating blood pressure

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  • Weight loss achieved via life-style modifications or through bariatric surgery have both been consistently associated with reductions in LV dimensions, LV wall thickness, LV mass, and LA dimension.

    “Weight loss achieved via life-style modifications or through bariatric surgery have both been consistently associated with reductions in LV dimensions, LV wall thickness, LV mass, and LA dimension (14, 16, 17, 169).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [169]

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Authors
Karason, K., Wallentin, I., Larsson, B., & Sjostrom, L.
Affiliations
Sahlgrenska University Hospital (SE)
Corresponding author
Karason, K.
ORCID
Venue
BMJ
Publisher
BMJ
Published
1997-10-11
Volume
315
Issue
7113
Pages
912-916
ISSN
  • 0007-1447 (ISSN-L)
  • 0959-8138
  • 1468-5833
DOI
10.1136/bmj.315.7113.912
PMC
PMC2127625
OpenAlex
W2005764705
Cited by
168
References
39
Citations by year
2024: 3 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 8 · 2019: 7 · 2018: 2 · 2017: 7 · 2016: 6 · 2015: 5 · 2014: 4 · 2013: 6 · 2012: 2
FWCI
3.41
Type
journal article
Language
en
Open access
Locations
  • BMJ (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Göteborgs Läkaresällskap
  • Sahlgrenska Universitetssjukhuset
  • Medical Research Council
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
Keywords
obesity, weight loss, left ventricular mass, relative wall thickness, left ventricular hypertrophy, gastric bypass, blood pressure, hypertension, cardiovascular risk factors
MeSH terms
Adult, Analysis of Variance, Blood Pressure, Cross-Sectional Studies, Female, Heart Ventricles, Humans, Male, Middle Aged, Obesity, Weight Loss, Body Mass Index

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