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Cited by 104Cardiovascular Function and Risk FactorsCardiovascular Disease and AdiposityDiabetes, Cardiovascular Risks, and Lipoproteins

Echocardiographic Abnormalities in Normotensive Obese Patients: Relationship with Visceral Fat

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Morricone, Lelio, Malavazos, Alexis Elias, Coman, Calin, Donati, Cristina, Hassan, Tamin, Caviezel, Francesco·2002·Obesity Research
DOI 10.1038/oby.2002.67
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Abstract

Objective: To evaluate the relationship of echocardiographic characteristics and visceral adipose tissue (VAT) distribution in normotensive obese patients. Research Methods and Procedures: Echocardiographic parameters were assessed in 28 normotensive obese patients [7 men, 21 women, mean age, 43.2 years; mean body mass index (BMI), 37.2 kg/m 2; 10 with impaired glucose tolerance (IGT); 6 with type 2 diabetes] and 18 sex‐ and age‐matched healthy, normal‐weight controls (4 men, 14 women; mean age, 45.8 years; mean BMI, 22.4 kg/m 2) by an M‐mode, color‐doppler videofluoroscope. VAT in the obese patients was assessed by computed tomography (at L4 level). Results: The obese patients had a significantly larger internal diastolic left ventricular (LV) diameter (p < 0.05), a thicker end‐diastolic septum (p < 0.001) and posterior wall (p < 0.001), a greater indexed (g/m 2.7) LV mass (p < 0.001), a higher atrial diastolic filling wave velocity (p < 0.001), a lower ratio between early and atrial diastolic filling wave velocities (p < 0.01), and a prolonged isovolumic relaxation time (p < 0.05). End‐diastolic septum and posterior wall thickness and the LV mass were significantly greater in patients with a VAT area >130 cm 2 than with <130 cm 2. In the multivariate regression analysis, only VAT (p < 0.0001), waist‐to‐hip ratio (p < 0.001), and sex (p < 0.001) were associated with the most important echocardiographic alterations. Discussion: The morphological and functional echocardiographic alterations usually found in normotensive obese patients closely correlate with the amount of intra‐abdominal fat deposition, even in the presence of diabetes or IGT.

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  • More recent data confirm the increased prevalence of LV hypertrophy in obese subjects.

    “The more recent data confirm the increased prevalence of LV hypertrophy in obese subjects.”

    From Cardiac remodeling in obesity (2008) · cites this paper as [242]

  • Both LV cavity size and wall thickness are increased in obese subjects compared with age-matched controls.

    “In addition, the results indicate that both LV cavity size and wall thickness are increased in obese subjects compared with age-matched controls (22, 134, 151, 156, 242, 279, 377).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [242]

  • Many published studies have concluded that obesity is independently associated with LV hypertrophy.

    “Many published studies have concluded that obesity is independently associated with LV hypertrophy (22, 28, 63, 72, 116, 235, 242, 266, 279, 284, 377).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [242]

  • LV ejection fraction is normal or even supranormal in the majority of obese subjects, even those with severe obesity.

    “More recently, however, several studies have found that LV ejection fraction is normal or even supranormal in the majority of obese subjects, even those with severe obesity (22, 28, 155, 191, 242, 274, 279, 375, 377).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [242]

  • Findings on LV ejection fraction in obese subjects are variable, with studies reporting depressed, normal, or supernormal EF.

    “Various authors have reported depressed LV ejection fraction (EF) (15, 68, 100), normal EF (22, 111, 116, 191, 242, 266, 279, 377), and supernormal EF (28, 155, 274, 375) in obese subjects.”

    From Cardiac remodeling in obesity (2008) · cites this paper as [242]

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  1. Enzi G, Pavan M, Digito M, et al. Clustering of metabolic abnormalities and other risk factors for cardiovascular disease in visceral obesity. Diab Nutr Metab. 1993;6:47-55.
  2. Heart and Fat Distribution in Obesity, Morricone et al. OBESITY RESEARCH Vol. 10 No. 6 June 2002 497 15508528, 2002, 6, Downloaded from https://onlinelibrary.wiley.com/doi/10.1038/oby.2002.67 by Universita Di Milano, Wiley Online Library on [28/02/2023]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License · DOI

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Authors
Morricone, L., Malavazos, A. E., Coman, C., Donati, C., Hassan, T., & Caviezel, F.
Affiliations
University of Milan (IT)
Corresponding author
Morricone, Lelio
ORCID
Venue
Obesity Research
Publisher
Wiley
Published
2002-06
Volume
10
Issue
6
Pages
489-498
ISSN
  • 1071-7323 (ISSN-L)
  • 1550-8528
DOI
10.1038/oby.2002.67
OpenAlex
W1985494866
Cited by
104
References
58
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 6 · 2013: 7 · 2012: 9
FWCI
1.53
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3750 d)
Locations
  • Obesity Research (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
obesity, visceral adipose tissue, left ventricular hypertrophy, left ventricular mass, diastolic function, impaired glucose tolerance, type 2 diabetes, waist-to-hip ratio, intra-abdominal fat, echocardiographic abnormalities
MeSH terms
Adipose Tissue, Adult, Blood Pressure, Body Composition, Female, Fluoroscopy, Humans, Male, Middle Aged, Obesity, Tomography, X-Ray Computed, Viscera, Body Mass Index, Glucose Intolerance, Echocardiography, Doppler, Color

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