Cited by 938Atrial Fibrillation Management and OutcomesChronic Obstructive Pulmonary Disease (COPD) ResearchStatistical Methods in Epidemiology

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Confidence intervals for the number needed to treat.

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Altman, Douglas G·1998·BMJ

DOI 10.1136/bmj.317.7168.1309PMC PMC1114210

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Abstract

Chronic obstructive pulmonary disease has been associated with a high frequency of arrhythmias. Few studies have analysed the role of reduced lung function in predicting atrial fibrillation (AF). The aim of the present study was to investigate the relationship between forced expiratory volume in one second (FEV1) and risk of first episode of AF in a prospective study. Data from 13,430 males and females without previous myocardial infarction, who participated in the Copenhagen City Heart Study, were analysed. New AF was assessed at re-examination after 5 yrs and by hospital admission for AF during a period of 13 yrs. Multivariate analyses were used with adjustment for cardiopulmonary risk factors. There were 62 new cases of AF at 5-yr follow-up (0.58%) and 290 cases (2.20%) diagnosed at hospitalisations. Risk of new AF at re-examination was 1.8-times higher for FEV1 between 60–80% of predicted compared with FEV1 ≥80% after adjustment for sex, age, smoking, blood pressure, diabetes and body mass index. The risk of AF hospitalisation was 1.3-times higher for FEV1 between 60–80% and 1.8-times higher for FEV1 <60% compared with FEV1 ≥80%, when additional adjustment was made for education, treatment with diuretics and chest pain at activity. The authors conclude that reduced lung function is an independent predictor for incident atrial fibrillation.

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Authors: Altman, D. G.
Corresponding author: Altman, Douglas G
ORCID: Altman, Douglas G
Venue: BMJ
Publisher: BMJ
Published: 1998-11-07
Volume: 317
Issue: 7168
Pages: 1309-1312
ISSN: 0007-1447 (ISSN-L)
0959-8138
1468-5833
DOI: 10.1136/bmj.317.7168.1309
PMC: PMC1114210
OpenAlex: W1982900907
Cited by: 938
References: 14
Citations by year: 2026: 29 · 2025: 16 · 2024: 33 · 2023: 30 · 2022: 36 · 2021: 36 · 2020: 32 · 2019: 39 · 2018: 29 · 2017: 30 · 2016: 39 · 2015: 32 · 2014: 43 · 2013: 29 · 2012: 32
FWCI: 19.72
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy (tdm)
Locations: BMJ (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
Keywords: atrial fibrillation, chronic obstructive pulmonary disease, lung function, FEV1, cardiac arrhythmias, risk prediction, Copenhagen City Heart Study
MeSH terms: Confidence Intervals, Randomized Controlled Trials as Topic, Sample Size, Risk Assessment

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