Reduced lung function and risk of atrial fibrillation in the Copenhagen City Heart Study
Open accessAbstract
Chronic obstructive pulmonary disease has been associated with a high frequency of arrhythmias. Few studies have analysed the role of reduced lung function in predicting atrial fibrillation (AF). The aim of the present study was to investigate the relationship between forced expiratory volume in one second (FEV1) and risk of first episode of AF in a prospective study. Data from 13,430 males and females without previous myocardial infarction, who participated in the Copenhagen City Heart Study, were analysed. New AF was assessed at re-examination after 5 yrs and by hospital admission for AF during a period of 13 yrs. Multivariate analyses were used with adjustment for cardiopulmonary risk factors. There were 62 new cases of AF at 5-yr follow-up (0.58%) and 290 cases (2.20%) diagnosed at hospitalisations. Risk of new AF at re-examination was 1.8-times higher for FEV1 between 60-80% of predicted compared with FEV1 > or = 80% after adjustment for sex, age, smoking, blood pressure, diabetes and body mass index. The risk of AF hospitalisation was 1.3-times higher for FEV1 between 60-80% and 1.8-times higher for FEV1 < 60% compared with FEV1 > or = 80%, when additional adjustment was made for education, treatment with diuretics and chest pain at activity. The authors conclude that reduced lung function is an independent predictor for incident atrial fibrillation.
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Chronic obstructive pulmonary disease is independently associated with AF, with FEV1 60-80% RR 1.28 and FEV1 <60% RR 2.53 compared with FEV1 ≥80%.
“Chronic obstructive pulmonary disease 209 FEV1 ≥ 80% 60-80% < 60% RR: 1.00 (reference) 1.28 (95% CI 0.79-2.06)2.53 (95% CI 1.45-4.42)”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [209]
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- Authors
- Buch, P., Friberg, J., Scharling, H., Lange, P., & Prescott, E.
- Affiliations
- Hvidovre Hospital (DK)
- Bispebjerg Hospital (DK)
- Copenhagen Municipal Hospital (DK)
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2003-06
- Volume
- 21
- Issue
- 6
- Pages
- 1012-1016
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2101874379
- Cited by
- 311
- References
- 25
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 14 · 2023: 18 · 2022: 11 · 2021: 18 · 2020: 35 · 2019: 20 · 2018: 22 · 2017: 18 · 2016: 22 · 2015: 14 · 2014: 20 · 2013: 19 · 2012: 11
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Respiratory Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hjerteforeningen
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- atrial fibrillation, reduced lung function, FEV1, chronic obstructive pulmonary disease, arrhythmia risk, Copenhagen City Heart Study
- MeSH terms
- Adult, Aged, Atrial Fibrillation, Denmark, Female, Follow-Up Studies, Forced Expiratory Volume, Humans, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Respiratory Function Tests, Risk Factors, Time Factors, Cohort Studies, Incidence, Pulmonary Disease, Chronic Obstructive
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