The DOI matches its Crossref record; 21 of the 22 references it cites were found in a registry or an index.
What can mendelian randomisation tell us about modifiable behavioural and environmental exposures?
Open accessAbstract
Using genetic variants as a proxy for modifiable environmental factors that are associated with disease can circumvent some of the problems of observational studies
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“The MR methodology used is less vulnerable to environmental confounding and reverse causation than traditional observational research strategies [6,7].”
From Associations of genetically determined iron status across the phenome: A mendelian randomization study (2019) · cites this paper as [6]
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Cites
Davey Smith, G., & Ebrahim, S. (2003) · International Journal of Epidemiology · doi:10.1093/ije/dyg070 · Cited by 5,882
Self-citationHomocysteine and cardiovascular disease: evidence on causality from a meta-analysis
Wald, D. S., Law, M., & Morris, J. K. (2002) · BMJ · doi:10.1136/bmj.325.7374.1202 · Cited by 1,945
A strategy to reduce cardiovascular disease by more than 80%
Wald, N., & Law, M. R. (2003) · BMJ · doi:10.1136/bmj.326.7404.1419 · Cited by 1,565
Mendelian randomization: prospects, potentials, and limitations
Smith, G. D. (2004) · International Journal of Epidemiology · doi:10.1093/ije/dyh132 · Cited by 1,222
Self-citationProblems of reporting genetic associations with complex outcomes
Colhoun, H. M., McKeigue, P., & Smith, G. D. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12715-8 · Cited by 1,203
Self-citation5, 10-Methylenetetrahydrofolate Reductase Gene Variants and Congenital Anomalies: A HuGE Review
Botto, L. D., & Yang, Q. (2000) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a010290 · Cited by 1,045
Epidemiological methods for studying genes and environmental factors in complex diseases
Clayton, D. G., & McKeigue, P. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06418-2 · Cited by 469
Lawlor, D. A., Smith, G. D., Bruckdorfer, K. R., Kundu, D., & Ebrahim, S. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16260-0 · Cited by 438
Self-citationRise and fall of modern medicine
Fanu, J. L. (1999) · The Lancet · doi:10.1016/s0140-6736(05)75559-8 · Cited by 298
Aldehyde Dehydrogenase 2 Gene Is a Risk Factor for Myocardial Infarction in Japanese Men.
Takagi, S., Iwai, N., Yamauchi, R., Kojima, S., Yasuno, S., Baba, T., Terashima, M., Tsutsumi, Y., Suzuki, S., Morii, I., et al. (2002) · Hypertension Research · doi:10.1291/hypres.25.677 · Cited by 144
Cited by
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Bowden, J., Davey Smith, G., Haycock, P. C., & Burgess, S. (2016) · Genetic Epidemiology · doi:10.1002/gepi.21965 · Cited by 8,922
Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology
Lawlor, D. A., Harbord, R. M., Sterne, J. A. C., Timpson, N., & Davey Smith, G. (2008) · Statistics in Medicine · doi:10.1002/sim.3034 · Cited by 4,618
Self-citationReading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians
Davies, N. M., Holmes, M. V., & Davey Smith, G. (2018) · BMJ · doi:10.1136/bmj.k601 · Cited by 4,404
Avoiding bias from weak instruments in Mendelian randomization studies
Burgess, S., Thompson, S. G., & CRP CHD Genetics Collaboration (2011) · International Journal of Epidemiology · doi:10.1093/ije/dyr036 · Cited by 3,952
Resilience as a dynamic concept
Rutter, M. (2012) · Development and Psychopathology · doi:10.1017/s0954579412000028 · Cited by 1,853
Metadata
- Authors
- Smith, G. D., & Ebrahim, S.
- Affiliations
- University of Bristol (GB)
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2005-05-05
- Volume
- 330
- Issue
- 7499
- Pages
- 1076-1079
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- PMC
- PMC557238
- OpenAlex
- W2096940418
- Cited by
- 545
- References
- 22
- Citations by year
- 2026: 13 · 2025: 33 · 2024: 66 · 2023: 37 · 2022: 29 · 2021: 39 · 2020: 61 · 2019: 15 · 2018: 31 · 2017: 19 · 2016: 14 · 2015: 14 · 2014: 18 · 2013: 22 · 2012: 23
- FWCI
- 10.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- BMJ (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- Bristol Research (University of Bristol) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Physical Sciences › Mathematics › Statistics and Probability › Advanced Causal Inference Techniques
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Keywords
- Mendelian randomization, environmental exposure, causal inference, observational study limitations
- MeSH terms
- Environmental Exposure, Humans, Polymorphism, Genetic, Recombination, Genetic, Genetic Variation, Health Behavior, Occupational Exposure, Genetic Predisposition to Disease
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