MMR vaccine and Crohn's disease: ecological study of hospital admissions in England, 1991 to 2002
Open accessAbstract
Valerie SeagroattIt has been hypothesised that the measles, mumps, and rubella vaccine (MMR vaccine) increases the risk of autism and Crohn's disease.Although a possible link with autism has been extensively studied and refuted, 1 a link with Crohn's disease has not.I tested this hypothesis by analysing trends in age specific admission rates for Crohn's disease in children and adolescents to determine if the introduction of MMR vaccine in 1988 increased rates in those populations that were offered the vaccine as infants.
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The introduction of the MMR vaccination programme in England did not increase the risk of Crohn's disease, with an estimated rate ratio of 0.95 (95% CI 0.84 to 1.08).
“The introduction of the MMR vaccination programme in England did not increase the risk of CD.”
From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as Seagroatt 2005
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Cites
MMR vaccination and pervasive developmental disorders: a case-control study
Smeeth, L., Cook, C., Fombonne, E., Heavey, L., Rodrigues, L. C., Smith, P. G., & Hall, A. J. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17020-7 · Cited by 263 · see citing works
Is measles vaccination a risk factor for inflammatory bowel disease?
Thompson, N. P., Pounder, R. E., Wakefield, A. J., & Montgomery, S. (1995) · The Lancet · doi:10.1016/s0140-6736(95)90816-1 · Cited by 213 · see citing works
Davis, R. L. (2001) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpedi.155.3.354 · Cited by 123 · see citing works
"Gold standard" is an appropriate term.
Versi, E. (1992) · BMJ · doi:10.1136/bmj.305.6846.187-b · Cited by 113 · see citing works
Time to abolish "gold standard"
Duggan, P. (1992) · BMJ · doi:10.1136/bmj.304.6841.1568-b · Cited by 36 · see citing works
Crohn’s disease, ulcerative colitis, and measles vaccine in an English population, 1979–1998
Seagroatt, V. A., & Goldacre, M. J. (2003) · Journal of Epidemiology & Community Health · doi:10.1136/jech.57.11.883 · Cited by 29 · see citing works
Self-citationMeasles, measles vaccination, and Crohn's disease
Miller, E. J., & Waight, P. (1998) · BMJ · doi:10.1136/bmj.316.7146.1745 · Cited by 27 · see citing works
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Vaccines for measles, mumps and rubella in children
Demicheli, V., Rivetti, A., Debalini, M. G., & Di Pietrantonj, C. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004407.pub3 · Cited by 372 · see citing works
- Authors
- Seagroatt, V.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Seagroatt, Valerie
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2005-04-18
- Volume
- 330
- Issue
- 7500
- Pages
- 1120-1121
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- PMC
- PMC557892
- OpenAlex
- W2106996695
- Cited by
- 21
- References
- 7
- Citations by year
- 2022: 1 · 2021: 3 · 2020: 1 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 1
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BMJ (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Social Sciences › Health › Vaccine Coverage and Hesitancy
- Keywords
- MMR vaccine, Crohn's disease, hospitalization, childhood immunization, vaccine safety, children and adolescents
- MeSH terms
- Adolescent, Child, Child, Preschool, Crohn Disease, England, Hospitalization, Humans, Infant, Infant, Newborn, Risk Factors, Age Distribution, Measles-Mumps-Rubella Vaccine
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