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Cited by 123Inflammatory Bowel DiseasePharmacovigilance and Adverse Drug ReactionsVirology and Viral Diseases

Measles-Mumps-Rubella and Other Measles-Containing Vaccines Do Not Increase the Risk for Inflammatory Bowel Disease<subtitle>A Case-Control Study From the Vaccine Safety Datalink Project</subtitle>

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Davis, Robert L.·2001·Archives of Pediatrics & Adolescent Medicine
DOI 10.1001/archpedi.155.3.354
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Abstract

CONTEXT: A link between measles virus-containing vaccines and inflammatory bowel disease (IBD) has been suggested by recent studies. OBJECTIVE: To address whether receipt or timing of measles-containing vaccine (MCV) increases risk for IBD. DESIGN: A case-control study. SETTING: Four large health maintenance organizations (HMOs) that are part of the Centers for Disease Control and Prevention's Vaccine Safety Datalink project. PATIENTS OR OTHER PARTICIPANTS: A total of 155 persons with codes from International Classification of Diseases, Ninth Revision specific for IBD, born between 1958 and 1989 and enrolled from birth to the onset of disease, were identified. Up to 5 controls were matched by sex, HMO, and birth year. INTERVENTION: None. MAIN OUTCOME MEASURES: Risk for IBD, Crohn's disease, and ulcerative colitis. RESULTS: Past vaccination was not associated with an increased risk for Crohn's disease (odds ratio [OR] for measles-mumps-rubella vaccine [MMR], 0.4; 95% confidence interval [CI], 0.08-2.0), ulcerative colitis (OR, 0.8; 95% CI, 0.18-3.56), or IBD (OR, 0.59; 95% CI, 0.21-1.68). Risk for IBD was not increased among children vaccinated who were younger than 12 months (OR for MMR, 0.61; 95% CI, 0.15-2.45) or aged 12 to 18 months (OR, 0.86; 95% CI, 0.28-2.59) relative to unvaccinated children. Children vaccinated with MMR who were older than 18 months were at significantly decreased risk for IBD (OR, 0.16; 95% CI, 0.04-0.68). Neither past vaccination nor age at vaccination with other MCV was associated with increased risk for Crohn's disease, ulcerative colitis, or IBD. Risk for Crohn's disease, ulcerative colitis, or IBD was not elevated in the time immediately following vaccination with either vaccine. CONCLUSIONS: Vaccination with MMR or other MCV, or the timing of vaccination early in life, did not increase the risk for IBD.

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  • In Black 1997 and Davis 2001, the risk of bias was low.

    “Low risk of bias: two studies (Black 1997; Davis 2001).”

    From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as Davis 2001

  • Exposure to the MMR vaccine was not associated with an increased risk of Crohn's disease (OR 0.4; 95% CI 0.08 to 2.0), ulcerative colitis (OR 0.80; 95% CI 0.18 to 3.56) or all inflammatory bowel disease (OR 0.59; 95% CI 0.21 to 1.69) in a US case-control study using Vaccine Safety Datalink data.

    “The authors concluded that exposure to the MMR vaccine was not associated with an increase risk of CD (OR 0.4; 95% CI 0.08 to 2.0), ulcerative colitis (OR 0.80; 95% CI 0.18 to 3.56) and all IBD (OR 0.59; 95% CI 0.21 to 1.69).”

    From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as Davis 2001

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Research works printed but not linked: 4

  1. Miller E, Waight P. Measles, measles vaccination and Crohn's's disease second immunisation has not affected incidence in England [letter]. BMJ. 1998;316: 1745.
  2. Chadwick N, Bruce IJ, Schepelmann S, Pounder RE, Wakefield AJ. Measles vi- rus RNA is not detected in inflammatory bowel disease using hybrid capture and reverse transcription followed by the polymerase chain reaction. J Med Virol. 1998;55:305-311.
  3. Measles, MMR, and autism: the confusion continues [editorial]. Lancet. 2000; 355:1379.
  4. Vaccine Safety Datalink Team National Immunization Program, Centers for Disease Con- trol and Prevention, Atlanta, Ga: Frank DeStefano, MD, MPH; Robert T. Chen, MD; John Glasser, PhD, MPH; Philip H. Rhodes, PhD; Piotr Kramarz, MD; Thomas Ver- straeten, MD; David Walker, MPH; Catherine Okoro Group Health Cooperative, Seattle, Wash: Robert S. Thomp- son, MD; Robert L. Davis, MD, MPH; Lisa A. Jackson, MD, MPH; Patti Benson, MPH; William Barlow, PhD; Kari Bohlke, ScD; Paula Lee Poy; David Rubanowice; Ann Zavitkovsky, MPH; Jo Ann Habakangas; Darren Malais; Wendy Rogers; Christi Hanson; Onchee Yu, MS; Viviana Rebolledo Kaiser Permanente Northwest Region, Portland, Ore: John P. Mullooly, PhD; Julie E. Maher, PhD; Sheila Weinman, PhD; Lois Drew, BA; Jill Mesa; Kim Olson; Heather Hous- ton, RN; Colleen Chun, MD; Steven Gancher, MD; John A. Pearson, MD; Jerry Slepak, MD; Alan Bauck, BS; Ter- esa Kimes, MS; Joseph Murphy, BA; Nadia Redmond, MSPH; Karen Riedlinger, MPH; Carol Sullivan; Gayle Tho- mas-Monk Kaiser Permanente of Northern California, Oakland: Steven B. Black, MD; Henry R. Shinefield, MD; Paula Ray, MPH; Edwin Lewis, MPH; Bruce H. Fireman, MA; Joan Schwalbe; Ajit De Silva; Patti Hallam Center for Vaccine Research, Harbor-UCLA Medical Cen- ter, Torrance, Calif: Joel I. Ward, MD; Connie M. Vad- heim, PhD; Hang Lee, PhD; Jennie Jing, MA; Nancy Goff Southern California Kaiser Permanente, Los Angeles: S. Mi- chael Marcy, MD; Marlene Lugg, DrPH Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Md: M. Miles Braun, MD, MPH;

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Authors
Davis, R. L.
Affiliations
Group Health Cooperative (US)
Corresponding author
Davis, Robert L.
ORCID
Davis, Robert L.
Venue
Archives of Pediatrics & Adolescent Medicine
Publisher
American Medical Association (AMA)
Published
2001-03-01
Volume
155
Issue
3
Pages
354
ISSN
1072-4710 (ISSN-L)
DOI
10.1001/archpedi.155.3.354
OpenAlex
W2115310959
Cited by
123
References
24
Citations by year
2025: 4 · 2022: 2 · 2021: 5 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 9 · 2014: 6 · 2013: 9 · 2012: 5
FWCI
5.82
Type
journal article
Language
en
Open access
Locations
  • Archives of Pediatrics and Adolescent Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Kaiser Permanente
  • Centers for Disease Control and Prevention
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords
measles-containing vaccine, inflammatory bowel disease, Crohn's disease, ulcerative colitis, vaccine safety, age at vaccination, vaccination timing, childhood immunization, vaccine adverse events, health maintenance organizations, measles incidence, mumps incidence, rubella incidence
MeSH terms
Adolescent, Adult, Child, Child, Preschool, Colitis, Ulcerative, Crohn Disease, Female, Humans, Infant, Male, Risk Factors, Inflammatory Bowel Diseases, Logistic Models, Case-Control Studies, Medical Records Systems, Computerized, Measles-Mumps-Rubella Vaccine

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