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Soft drinks, fructose consumption, and the risk of gout in men: prospective cohort study
Open accessAbstract
OBJECTIVE: To examine the relation between intake of sugar sweetened soft drinks and fructose and the risk of incident gout in men. DESIGN: Prospective cohort over 12 years. SETTING: Health professionals follow-up study. PARTICIPANTS: 46 393 men with no history of gout at baseline who provided information on intake of soft drinks and fructose through validated food frequency questionnaires. MAIN OUTCOME MEASURE: Incident cases of gout meeting the American College of Rheumatology survey criteria for gout. RESULTS: During the 12 years of follow-up 755 confirmed incident cases of gout were reported. Increasing intake of sugar sweetened soft drinks was associated with an increasing risk of gout. Compared with consumption of less than one serving of sugar sweetened soft drinks a month the multivariate relative risk of gout for 5-6 servings a week was 1.29 (95% confidence interval 1.00 to 1.68), for one serving a day was 1.45 (1.02 to 2.08), and for two or more servings a day was 1.85 (1.08 to 3.16; P for trend=0.002). Diet soft drinks were not associated with risk of gout (P for trend=0.99). The multivariate relative risk of gout according to increasing fifths of fructose intake were 1.00, 1.29, 1.41, 1.84, and 2.02 (1.49 to 2.75; P for trend <0.001). Other major contributors to fructose intake such as total fruit juice or fructose rich fruits (apples and oranges) were also associated with a higher risk of gout (P values for trend <0.05). CONCLUSIONS: Prospective data suggest that consumption of sugar sweetened soft drinks and fructose is strongly associated with an increased risk of gout in men. Furthermore, fructose rich fruits and fruit juices may also increase the risk. Diet soft drinks were not associated with the risk of gout.
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“Hyperuricaemia is a precursor to gout.109 110”
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“Many studies have confirmed that excessive fructose consumption can promote uric acid synthesis by inducing degradation ATP to AMP, a substrate for uric acid production.109 110 111”
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Cites
Statistical Abstract of the U nited S tates
(2005) · Wiley eBooks · doi:10.1002/0471667196.ess2527 · Cited by 8,872
A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure
Appel, L. J., Moore, T. J., Obarzanek, E., Vollmer, W. M., Svetkey, L. P., Sacks, F. M., Bray, G. A., Vogt, T. M., Cutler, J. A., Windhauser, M. M., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704173361601 · Cited by 5,981
Sacks, F. M., Svetkey, L. P., Vollmer, W. M., Appel, L. J., Bray, G. A., Harsha, D., Obarzanek, E., Conlin, P. R., Miller, E. R., Simons-Morton, D. G., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200101043440101 · Cited by 5,638
Principles and Practice of Sleep Medicine
Kryger, M. H., Roth, T. G., & Dement, W. C. (2011) · Elsevier eBooks · doi:10.1016/c2009-0-59875-3 · Cited by 5,118
Willett, W. C. (1998) · doi:10.1093/acprof:oso/9780195122978.001.0001 · Cited by 4,541
Reproducibility and validity of a semiquantitative food frequency questionnaire
WILLETT, W. C., SAMPSON, L., STAMPFER, M. J., ROSNER, B., BAIN, C., WITSCHI, J., HENNEKENS, C. H., & SPEIZER, F. E. (1985) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114086 · Cited by 4,274
Ludwig, D. S., Peterson, K. E., & Gortmaker, S. L. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04041-1 · Cited by 2,414
Rimm, E. B., Giovannucci, E. L., Stampfer, M. J., Colditz, G. A., Litin, L. B., & Willett, W. C. (1992) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116211 · Cited by 2,104
Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity
Bray, G. A., Nielsen, S. J., & Popkin, B. M. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.4.537 · Cited by 1,990
Dietary Fat Intake and the Risk of Coronary Heart Disease in Women
Hu, F. B., Stampfer, M. J., Manson, J. E., Rimm, E. B., Colditz, G. A., ROSNER, B. A., Hennekens, C. H., & Willett, W. C. (1997) · New England Journal of Medicine · doi:10.1056/nejm199711203372102 · Cited by 1,774
The principles and practice of medicine
(1938) · The American Journal of Surgery · doi:10.1016/s0002-9610(38)91188-2 · Cited by 1,657
Schulze, M. B. (2004) · JAMA · doi:10.1001/jama.292.8.927 · Cited by 1,639
Preliminary criteria for the classification of the acute arthritis of primary gout
Wallace, S. L., Robinson, H., Masi, A. T., Decker, J. L., McCarty, D. J., & Yű, T.-F. (1977) · Arthritis & Rheumatism · doi:10.1002/art.1780200320 · Cited by 1,433
The Effect of Fruit and Vegetable Intake on Risk for Coronary Heart Disease
Joshipura, K. J., Hu, F. B., Manson, J. E., Stampfer, M. J., Rimm, E. B., Speizer, F. E., Colditz, G., Ascherio, A., Rosner, B., Spiegelman, D., et al. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-12-200106190-00010 · Cited by 1,396
Fruit and vegetable intake and risk of major chronic disease
Hung, H.-C., Joshipura, K. J., Jiang, R., Hu, F. B., Hunter, D., Smith-Warner, S. A., Colditz, G. A., Rosner, B., Spiegelman, D., & Willett, W. C. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh296 · Cited by 1,327
Purine-Rich Foods, Dairy and Protein Intake, and the Risk of Gout in Men
Choi, H. K., Atkinson, K. A., Karlson, E. W., Willett, W. C., & Curhan, G. C. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa035700 · Cited by 1,183
Self-citationFruit and Vegetable Intake in Relation to Risk of Ischemic Stroke
Joshipura, K. J. (1999) · JAMA · doi:10.1001/jama.282.13.1233 · Cited by 1,078
Dietary Guidelines for Americans 2005
SKOLNIK, N., & King, M. (2005) · Family Practice News · doi:10.1016/s0300-7073(05)71075-6 · Cited by 1,072
Feskanich, D., Rimm, E. B., Giovannucci, E. L., Colditz, G. A., Stampfer, M. J., Litin, L. B., & Willett, W. C. (1993) · Journal of the American Dietetic Association · doi:10.1016/0002-8223(93)91754-e · Cited by 1,070
Choi, H. K., Mount, D. B., & Reginato, A. M. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-143-7-200510040-00009 · Cited by 943
Self-citationAsymptomatic hyperuricemia. Risks and consequences in the normative aging study
Campion, E. W., Glynn, R. J., & Delabry, L. O. (1987) · The American Journal of Medicine · doi:10.1016/0002-9343(87)90441-4 · Cited by 851
Dietary Guidelines for Americans, 2005
Mosocco, D. J. (2006) · Home Healthcare Now · doi:10.1097/00004045-200610000-00002 · Cited by 798
B IOLOGIC M ECHANISMS OF THE P ROTECTIVE R OLE OF L UTEIN AND Z EAXANTHIN IN THE E YE
Krinsky, N. I., Landrum, J. T., & Bone, R. A. (2003) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.23.011702.073307 · Cited by 779
Alcohol intake and risk of incident gout in men: a prospective study
Choi, H. K., Atkinson, K. A., Karlson, E. W., Willett, W. C., & Curhan, G. C. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16000-5 · Cited by 753
Self-citationGross, L. S., Li, L., Ford, E. S., & Liu, S. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.774 · Cited by 681
Obesity, Weight Change, Hypertension, Diuretic Use, and Risk of Gout in Men
Choi, H. K., Atkinson, K. A., Karlson, E. W., & Curhan, G. C. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.7.742 · Cited by 629
Self-citationHealth and nutritionPreprint
Behrman, J. R., & Deolalikar, A. B. (1988) · RePEc: Research Papers in Economics · Cited by 574
Emmerson, B. T. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602153340707 · Cited by 516
Choi, H. K., Ford, E. S., Li, C., & Curhan, G. C. (2007) · Arthritis Care & Research · doi:10.1002/art.22466 · Cited by 468
Self-citationTordoff, M. G., & Alleva, A. (1990) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/51.6.963 · Cited by 444
Nakagawa, T., Tuttle, K. R., Short, R. A., & Johnson, R. J. (2005) · Nature Clinical Practice Nephrology · doi:10.1038/ncpneph0019 · Cited by 382
Epidemiology of gout: is the incidence rising?
Arromdee, E., Michet, C. J., Crowson, C. S., O’Fallon, W. M., & Gabriel, S. E. (2002) · PubMed · Cited by 377
Gout and coronary heart disease: The framingham study
Abbott, R. D., Brand, F. N., Kannel, W. B., & Castelli, W. P. (1988) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(88)90127-8 · Cited by 355
Fructose-induced in vivo insulin resistance and elevated plasma triglyceride levels in rats
Thorburn, A. W., Storlien, L. H., Jenkins, A. B., Khouri, S., & Kraegen, E. W. (1989) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/49.6.1155 · Cited by 348
The Principles and Practice of Medicine
Osler, S. W. (1944) · Southern Medical Journal · doi:10.1097/00007611-194407000-00016 · Cited by 348
Faller, J., & Fox, I. H. (1982) · New England Journal of Medicine · doi:10.1056/nejm198212233072602 · Cited by 333
FRUCTOSE-INDUCED HYPERURICÆMIA
Stirpe, F., Corte, E. D., Bonetti, E., Abbondanza, A., Abbati, A., & Stefano, F. D. (1970) · The Lancet · doi:10.1016/s0140-6736(70)92269-5 · Cited by 331
Effect of Oestrogen Therapy on Plasma and Urinary Levels of Uric Acid
Nicholls, A., Snaith, M. L., & Scott, J. T. (1973) · BMJ · doi:10.1136/bmj.1.5851.449 · Cited by 274
Cho, E. (2004) · Archives of Ophthalmology · doi:10.1001/archopht.122.6.883 · Cited by 266
Effect of fructose feeding on insulin secretion and insulin action in the rat
Zavaroni, I., Sander, S., Scott, S., & Reaven, G. M. (1980) · Metabolism · doi:10.1016/0026-0495(80)90041-4 · Cited by 254
Choi, H. K., & Curhan, G. C. (2007) · Arthritis Care & Research · doi:10.1002/art.22762 · Cited by 240
Self-citationIncidence and Risk Factors for Gout in White Men
Roubenoff, R. (1991) · JAMA · doi:10.1001/jama.1991.03470210072035 · Cited by 237
Studies on the mechanism of fructose-induced hyperuricemia in man
Fox, I. H., & Kelley, W. N. (1972) · Metabolism · doi:10.1016/0026-0495(72)90120-5 · Cited by 231
Gout, diet, and the insulin resistance syndrome.
Fam, A. G. (2002) · PubMed · Cited by 225
Foods contributing to energy intake in the US: data from NHANES III and NHANES 1999–2000
Block, G. (2004) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2004.02.007 · Cited by 223 · cited 1×
“coincided with a substantial increase in the consumption of soft drinks and fructose.”
BackgroundDietary protein and risk of ischemic heart disease in women
Hu, F. B., Stampfer, M. J., Manson, J. E., Rimm, E. B., Colditz, G. A., Speizer, F. E., Hennekens, C. H., & Willett, W. C. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.70.2.221 · Cited by 208
Beck-Nielsen, H., Pedersen, O., & Lindskov, H. (1980) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/33.2.273 · Cited by 185
Ethanol-induced activation of adenine nucleotide turnover. Evidence for a role of acetate.
Puig, J., & Fox, I. H. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111512 · Cited by 174
Prevalence of the metabolic syndrome among 40,698 Korean metropolitan subjects
Lee, W., Park, J.-S., Noh, S.-Y., Rhee, E., Kim, S. W., & Zimmet, P. (2004) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2003.12.007 · Cited by 160
Effect of oral fructose on urate production.
Emmerson, B. T. (1974) · Annals of the Rheumatic Diseases · doi:10.1136/ard.33.3.276 · Cited by 158
Sugar-Sweetened Soft Drinks, Obesity, and Type 2 Diabetes
Apovian, C. M. (2004) · JAMA · doi:10.1001/jama.292.8.978 · Cited by 148
Metabolic Syndrome and Ischemic Heart Disease in Gout
Vázquez‐Mellado, J., García-García, C., Vázquez, S. G., Medrano, G., Ornelas, M., Alcocer, L. A., Marquez, A., & Burgos‐Vargas, R. (2004) · JCR Journal of Clinical Rheumatology · doi:10.1097/01.rhu.0000129082.42094.fc · Cited by 133
Racial differences in the incidence of gout
Hochberg, M. C., Thomas, J. W., Thomas, D., Mead, L. A., Levine, D., & Klag, M. J. (1995) · Arthritis & Rheumatism · doi:10.1002/art.1780380508 · Cited by 131
Gout: epidemiology and lifestyle choices.
Choi, H. K., & Curhan, G. C. (2005) · PubMed · Cited by 126
Self-citationWu, T., Giovannucci, E., Pischon, T., Hankinson, S. E., Ma, J., Rifai, N., & Rimm, E. B. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.4.1043 · Cited by 123
Hallfrisch, J. G., Ellwood, K. C., Michaelis, O. E., Reiser, S., O’Dorisio, T. M., & Prather, E. S. (1983) · Journal of Nutrition · doi:10.1093/jn/113.9.1819 · Cited by 122
Disordered metabolism in diabetes: Have we underemphasized the fat component?
McGarry, J. (1994) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240550005 · Cited by 107
Long-Term Effects of Moderate Fructose Feeding on Glucose Tolerance Parameters in Rats
Blakely, S. R., Hallfrisch, J. G., Reiser, S., & Prather, E. S. (1981) · Journal of Nutrition · doi:10.1093/jn/111.2.307 · Cited by 100
Stimulation of human purine synthesis de novo by fructose infusion
Raivio, K. O., Becker, M. A., Meyer, L. J., Greene, M. L., Nuki, G., & Seegmiller, J. E. (1975) · Metabolism · doi:10.1016/0026-0495(75)90133-x · Cited by 95
A controlled study of diet in patients with gout.
Gibson, T., Rodgers, A., Simmonds, H. A., Court-Brown, F., TODD, E., & Meilton, V. (1983) · Annals of the Rheumatic Diseases · doi:10.1136/ard.42.2.123 · Cited by 94
Hyperuricemia: A Marker for Cell Energy Crisis
Fox, I. H., Palella, T. D., & Kelley, W. N. (1987) · New England Journal of Medicine · doi:10.1056/nejm198707093170209 · Cited by 89
Metabolic Effects of Fructose Supplementation in Diabetic Individuals
Anderson, J. W., Story, L. J., Zettwoch, N. C., Gustafson, N., & Jefferson, B. S. (1989) · Diabetes Care · doi:10.2337/diacare.12.5.337 · Cited by 86
Shadick, N. A., Kim, Y., Weiss, S. T., Liang, M. H., Sparrow, D., & Hu, H. (2000) · PubMed · Cited by 82
FRUCTOSE-INDUCED HYPERURICÆMIA
Heuckenkamp, P.-U., & Zöllner, N. (1971) · The Lancet · doi:10.1016/s0140-6736(71)91259-1 · Cited by 72
Moeller, S. M., Taylor, A., Tucker, K. L., Jacques, P. F., McCullough, M. L., Chylack, L. T., Hankinson, S. E., & Willett, W. C. (2004) · Journal of Nutrition · doi:10.1093/jn/134.7.1812 · Cited by 68
Elliott, W. J. (2006) · Yearbook of Cardiology · doi:10.1016/s0145-4145(07)70013-8 · Cited by 67
A case-control study of alcohol consumption and drinking behaviour in patients with acute gout.
Cr, S. (1984) · PubMed · Cited by 46
Incidence and risk factors for gout in white men
Roubenoff, R. (1991) · JAMA · doi:10.1001/jama.266.21.3004 · Cited by 45
Freis, E. D. (1960) · American Journal of Public Health and the Nations Health · doi:10.2105/ajph.50.3_pt_2.11 · Cited by 37
Rizkalla, S. W., Boillot, J., Tricottet, V., Fontvieille, A.-M., Luo, J., Salzman, J.-L., Camilleri, J.-P., & Slama, G. (1993) · British Journal Of Nutrition · doi:10.1079/bjn19930117 · Cited by 37
Asymptomatic Hyperuricemia. Risks and Consequences in the Normative Aging Study
Campion, E. W., Glynn, R. J., & Delabry, L. O. (1987) · The Journal of Urology · doi:10.1016/s0022-5347(17)43321-0 · Cited by 23
The Effect of Acid Loading on Renal Excretion of Uric Acid and Ammonium in Gout
Gibson, T., Hannan, S., Hatfield, P. J., Simmonds, H. A., Cameron, J. S., Potter, C. S., & Crute, C. M. (1977) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-3285-5_6 · Cited by 17
FRUCTOSE-INDUCED HYPERURICÆMIA
Keene, D. S. (1967) · The Lancet · doi:10.1016/s0140-6736(67)90718-0 · Cited by 9
Lawrence (1998) · doi:10.1002/1529-0131(199805)41:5
Research works printed but not linked: 3
- Stirpe F, Della Corte E, Bonetti E, Abbondanza A, Abbati A, De Stefano F. Fructose-induced hyperuricaemia. Lancet 1970;2:1310-1.
- Perheentupa J, Raivio K. Fructose-induced hyperuricaemia. Lancet 1967;2:528-31.
- Krinsky NI, Landrum JT, Bone RA. Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye. Annu Rev Nutr 2003;23:171-201.
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Self-citation
Metadata
- Authors
- Choi, H. K., & Curhan, G.
- Affiliations
- University of British Columbia (CA)
- Brigham and Women's Hospital (US)
- Corresponding author
- Choi, Hyon K
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2008-01-31
- Volume
- 336
- Issue
- 7639
- Pages
- 309-312
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- PMC
- PMC2234536
- OpenAlex
- W2063161169
- Cited by
- 577
- References
- 74
- Citations by year
- 2026: 13 · 2025: 9 · 2024: 19 · 2023: 22 · 2022: 28 · 2021: 29 · 2020: 26 · 2019: 26 · 2018: 38 · 2017: 30 · 2016: 40 · 2015: 28 · 2014: 50 · 2013: 44 · 2012: 38
- FWCI
- 36.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BMJ (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Arthritis Society
- National Institutes of Health (CA55075)
- National Institute on Alcohol Abuse and Alcoholism (AA-11181, R01AA011181)
- National Heart, Lung, and Blood Institute (R01HL035464, HL35464)
- National Cancer Institute (CA-55075)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-58573)
- Topics
- Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- gout, sugar-sweetened beverages, fructose consumption, diet soft drinks, fruit juice, men, hyperuricemia, dietary risk factors
- MeSH terms
- Alcohol Drinking, Beverages, Diet, Epidemiologic Methods, Fructose, Gout, Humans, Male, Body Mass Index
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