Prospective Study of Intake of Fruits, Vegetables, Vitamins, and Carotenoidsand Risk of Age-Related Maculopathy
Abstract
OBJECTIVE: To examine the intake of antioxidant vitamins and carotenoids as well as fruits and vegetables in relation to the development of age-related maculopathy (ARM). METHODS: We conducted a prospective follow-up study of women in the Nurses' Health Study and men in the Health Professionals Follow-up Study. We followed 77 562 women and 40 866 men who were at least 50 years of age and had no diagnosis of ARM or cancer at baseline for up to 18 years for women and up to 12 years for men. Fruit and vegetable intakes were assessed with a validated semiquantitative food-frequency questionnaire up to 5 times for women and up to 3 times for men during follow-up. RESULTS: A total of 464 (329 women and 135 men) incident cases of early ARM and 316 (217 women and 99men) cases of neovascular ARM, all with visual loss of 20/30 or worse due primarily to ARM, were diagnosed during follow-up. Fruit intake was inversely associated with the risk of neovascular ARM. Participants who consumed 3 or more servings per day of fruits had a pooled multivariate relative risk of 0.64 (95% confidence interval, 0.44-0.93; P value for trend =.004) compared with those who consumed less than 1.5 servings per day. The results were similar in women and men. However, intakes of vegetables, antioxidant vitamins, or carotenoids were not strongly related to either early or neovascular ARM. CONCLUSION: These data suggest a protective role for fruit intake on the risk of neovascular ARM.
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Another study found no association between dietary lutein and zeaxanthin intake and age-related macular degeneration.
“However, another study found no such association.101”
From Age-related macular degeneration (2008) · cites this paper as [101]
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- Authors
- Cho, E.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Cho, Eunyoung
- ORCID
- Cho, Eunyoung
- Venue
- Archives of Ophthalmology
- Publisher
- American Medical Association (AMA)
- Published
- 2004-06-01
- Volume
- 122
- Issue
- 6
- Pages
- 883
- ISSN
- 0003-9950 (ISSN-L)
- OpenAlex
- W2149867743
- Cited by
- 266
- References
- 55
- Citations by year
- 2025: 4 · 2024: 6 · 2023: 9 · 2022: 13 · 2021: 9 · 2020: 10 · 2019: 9 · 2018: 10 · 2017: 13 · 2016: 14 · 2015: 14 · 2014: 12 · 2013: 15 · 2012: 21
- FWCI
- 22.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL035464, HL35464)
- National Eye Institute (R01EY009611, EY09611)
- National Cancer Institute (CA-87969, CA-55075, P01CA087969)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- age-related maculopathy, fruit consumption, vegetable consumption, antioxidant vitamins, carotenoids, dietary intake, vision loss, disease risk factors, Nurses' Health Study, Health Professionals Follow-up Study
- MeSH terms
- Adult, Aged, Antioxidants, Carotenoids, Diet, Feeding Behavior, Female, Follow-Up Studies, Fruit, Humans, Macular Degeneration, Male, Middle Aged, Prospective Studies, Risk Factors, United States, Vegetables, Vitamins, Diet Records, Incidence
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