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Cited by 40Ovarian function and disordersReproductive Health and TechnologiesReproductive Biology and Fertility

Current concepts in the treatment of anovulation

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Rabau, E, Serr, D M, Mashiach, S, Insler, V, Salomy, M, Lunenfeld, B·1967·BMJ
DOI 10.1136/bmj.4.5577.446PMC PMC1748542
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Abstract

MEDIBCAILIJUNAL residual follicle stimulating hormone secretion leading to the production of polycystic ovaries (Ferriman, 1960) ; all follicle stimulating hormone secretion may have disappeared in the more severely affected patients.The development of sensitive and precise radio-immunological assays for gonadotrophins may shed some light on the problem before long.The incidence of conception in our series (9 out of 41) is higher than we would have anticipated from our previous experiences in the field.This has been the experience of many other workers (Greenblatt, 1966).It is not possible to make a precise statistical assessment of the comparative value of this drug in the absence of control data.The provision of such data would be of great interest.It is odd that while patients with polycystic ovaries show a better ovulatory response to clomiphene than those with normal- sized ovaries their conception rate should be lower.Perhaps the thickened capsules of the polycystic ovaries interfere with the release of ova, or the increased production of androgen by these ovaries impairs nidation. SummaryThe ovulatory response to clomiphene is significantly better in patients with menstrual cycles of less than six months' dura- tion compared with those whose cycles exceed this figure, and in patients with polycystic ovaries compared with those whose ovaries are of normal size.It is better in patients with basal oestrogen excretions exceeding 21 ,ug./24hours than in those whose excretion levels fall below this figure (obtained by a method having a nonspecific background fluorescence of 10 xug./24 hours), though the difference does not quite reach formal significance.Patients with normal-sized ovaries conceive more readily than those with polycystic ovaries.The difference does not quite reach formal significance.We wish to thank Dr. D.

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  • Clomiphene citrate treatment is associated with a discrepancy between ovulation and conception rates, and a higher incidence of miscarriage than in the general population.

    “In addition, CC treatment is associated with a discrepancy between ovulation and conception rates, and the incidence of miscarriage is higher than in the general population (2)(3)(4)(5).”

    From A randomized trial of letrozole versus clomiphene citrate in women undergoing superovulation (2004) · cites this paper as [4]

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  1. Bishop, P. M. F. (1965). Proc. roy. Soc. Med., 58, 905.

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Authors
Rabau, E., Serr, D. M., Mashiach, S., Insler, V, Salomy, M., & Lunenfeld, B.
Affiliations
Tel Aviv University (IL)
Venue
BMJ
Publisher
BMJ
Published
1967-11-25
Volume
4
Issue
5577
Pages
446-449
ISSN
  • 0007-1447 (ISSN-L)
  • 0959-8138
  • 1468-5833
DOI
10.1136/bmj.4.5577.446
PMC
PMC1748542
OpenAlex
W1963595907
Cited by
40
References
11
Citations by year
2022: 1 · 2018: 1 · 2015: 1 · 2014: 1 · 2012: 1
FWCI
3.58
Type
journal article
Language
en
Open access
Locations
  • BMJ (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords
anovulation, clomiphene citrate, polycystic ovary, ovulation induction, conception rate, menstrual cycle length, gonadotropin secretion, follicle-stimulating hormone
MeSH terms
Chiari-Frommel Syndrome, Clomiphene, Female, Chorionic Gonadotropin, Gonadotropins, Pituitary, Humans, Hypopituitarism, Infertility, Female, Polycystic Ovary Syndrome, Pregnancy

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