The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Disturbance of Calcium Metabolism by Anticonvulsant Drugs
Open accessAbstract
A survey of calcium metabolism in epileptic patients in a residential centre showed a subnormal serum calcium level in 22.5% of patients and a raised alkaline phosphatase in 29%. Hypocalcaemia was related to high dosage of anticonvulsant drugs, to multiple drug therapy, and to the use of individual anticonvulsant drugs in the following order, with decreasing order of importance: pheneturide, primidone, phenytoin, phenobarbitone. Subnormal serum calcium levels occurred more commonly in patients with a raised liver alkaline phosphatase isoenzyme than in those whose phosphatase was mainly of bone origin.Preliminary results of treatment with calciferol suggested that the disturbance of calcium metabolism was the result of vitamin D deficiency. It is possible that anticonvulsant drugs accelerate the breakdown of vitamin D by liver enzyme induction.
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Citations
Cites
Osteomalacia with Long-term Anticonvulsant Therapy in Epilepsy
Dent, C. E., Richens, A., Rowe, D. J., & Stamp, T. C. B. (1970) · BMJ · doi:10.1136/bmj.4.5727.69 · Cited by 423
Self-citationMetabolism of Vitamin D3-3H in Human Subjects: Distribution in Blood, Bile, Feces, and Urine*
Avioli, L. V., Lee, S. W., McDonald, J. E., Lund, J., & DeLuca, H. F. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105605 · Cited by 178
Cited by
Effect of antiepileptic drugs on bone density in ambulatory patients
Farhat, G., Yamout, B., Mikati, M. A., Demirjian, S., Sawaya, R., & El-Hajj Fuleihan, G. (2002) · Neurology · doi:10.1212/wnl.58.9.1348 · Cited by 358
Phenobarbital-Induced Alterations in Vitamin D Metabolism
Hahn, T. J., Birge, S. J., Scharp, C. R., & Avioli, L. V. (1972) · Journal of Clinical Investigation · doi:10.1172/jci106868 · Cited by 309
Conney, A. H., & Burns, J. J. (1972) · Science · doi:10.1126/science.178.4061.576 · Cited by 260
“Anticonvulsant action” of vitamin D in epileptic patients? A controlled pilot study
Christiansen, C., Rødbro, P., & Sjö, O. (1974) · BMJ · doi:10.1136/bmj.2.5913.258 · Cited by 112
Menon, B., & Harinarayan, C. V. (2010) · Seizure · doi:10.1016/j.seizure.2010.01.006 · Cited by 70
Metadata
- Authors
- Richens, A., & Rowe, D. J. F.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1970-10-10
- Volume
- 4
- Issue
- 5727
- Pages
- 73-76
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- OpenAlex
- W2008017621
- Cited by
- 377
- References
- 2
- FWCI
- 48.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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