“Anticonvulsant action” of vitamin D in epileptic patients? A controlled pilot study
Open accessAbstract
The frequency of epileptic seizures was observed in a controlled therapeutic trial on 23 epileptic inpatients before and after treatment with vitamin D 2 or placebo in addition to anticonvulsant drugs. The number of seizures was reduced during treatment with vitamin D 2 but not with placebo. The effect was unrelated to changes in serum calcium or magnesium. The results may support the concept that epileptics should be treated prophylactically with vitamin D.
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Correction of vitamin D deficiency in patients with seizures decreased the frequency of seizures by 30%-40%.
“Correction of vitamin D deficiency in patients with seizures, decreased the frequency of seizures by 30%–40% [197,198].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [198]
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Cites
Disturbance of Calcium Metabolism by Anticonvulsant Drugs
Richens, A., & Rowe, D. J. (1970) · BMJ · doi:10.1136/bmj.4.5727.73 · Cited by 378 · see citing works
Principles of Medical Statistics
Benjamin, B. (1967) · Journal of Medical Genetics · doi:10.1136/jmg.4.1.72-a · Cited by 223 · see citing works
Incidence of Anticonvulsant Osteomalacia and Effect of Vitamin D: Controlled Therapeutic Trial
Christiansen, C., Rødbro, P., & Lund, M. (1973) · BMJ · doi:10.1136/bmj.4.5894.695 · Cited by 161 · see citing works
Self-citationLetter: Anticonvulsant hypomagnesaemia.
Christiansen, C. B., Nielsen, S. P., & Rødbro, P. (1974) · BMJ · doi:10.1136/bmj.1.5900.198-e · Cited by 13 · see citing works
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- Richens, A., and Rowe, D. J. F. (1970). British Medical Journal, 4, 73. on 11 July 2023 by guest. Protected by copyright. http://www.bmj.com/ Br Med J: first published as 10.1136/bmj.2.5913.258 on 4 May 1974. Downloaded from
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Vitamin D as a neurosteroid affecting the developing and adult brain
Groves, N. J., McGrath, J. J., & Burne, T. H. J. (2014) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071813-105557 · Cited by 256 · see citing works
Correction of vitamin D deficiency improves seizure control in epilepsy: A pilot study
Holló, A., Clemens, Z., Kamondi, A., Lakatos, P., & Szűcs, A. (2012) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2012.03.011 · Cited by 149 · see citing works
Vitamin D and Autism Spectrum Disorder: A Literature Review
Mazahery, H., Camargo, C., Conlon, C., Beck, K., Kruger, M., & Von Hurst, P. (2016) · Nutrients · doi:10.3390/nu8040236 · Cited by 110 · see citing works
Anticonvulsant effects of 1,25-dihydroxyvitamin D in chemically induced seizures in mice
Kalueff, A. V., Minasyan, A., & Tuohimaa, P. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2005.06.022 · Cited by 94 · see citing works
Siegel, A., Malkowitz, L., Moskovits, M. J., & Christakos, S. (1984) · Brain Research · doi:10.1016/0006-8993(84)91153-3 · Cited by 78 · see citing works
- Authors
- Christiansen, C., Rødbro, P., & Sjö, O.
- ORCID
- Christiansen, Claus
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1974-05-04
- Volume
- 2
- Issue
- 5913
- Pages
- 258-259
- ISSN
- 0007-1447 (ISSN-L)
- 1468-5833
- OpenAlex
- W2032738705
- Cited by
- 112
- References
- 4
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 5 · 2020: 4 · 2019: 8 · 2018: 4 · 2017: 2 · 2016: 8 · 2015: 2 · 2014: 3 · 2013: 8 · 2012: 1
- FWCI
- 7.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy (tdm)
- Locations
- BMJ (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Keywords
- vitamin D, vitamin D2, epilepsy, anticonvulsant activity, seizure frequency, anticonvulsant prophylaxis, serum calcium, serum magnesium, antiepileptic drugs
- MeSH terms
- Adolescent, Adult, Alkaline Phosphatase, Anticonvulsants, Calcium, Child, Clinical Trials as Topic, Epilepsy, Epilepsy, Tonic-Clonic, Female, Humans, Magnesium, Male, Phenobarbital, Phenytoin, Placebos, Primidone, Vitamin D
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