Cited by 704HIV-related health complications and treatmentsHIV/AIDS drug development and treatmentHIV/AIDS Research and Interventions

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

HIV infection, antiretroviral treatment, ageing, and non-AIDS related morbidity.

Deeks, S. G, Phillips, A. N·2009·BMJ

DOI 10.1136/bmj.a3172

Open this paper in CoChat — free account

Abstract

#### Summary points More than 25 antiretroviral drugs from six therapeutic classes are now available for the management of HIV infection (box 1). Most patients who take medication achieve durable and perhaps lifelong viral suppression, so the classic AIDS related conditions are becoming less common. However, treated patients do not have completely restored health. Compared with people without HIV infection, patients with the infection who are treated with antiretrovirals have increased risk for several “non-AIDS” complications, many of which are commonly associated with ageing (box 2). This risk is particularly evident in patients whose CD4+ T cell counts are below normal during long term treatment, but it is also seen to some extent in those with higher CD4+ T cell counts. As a consequence of the changing spectrum of HIV associated disease, the medical management of HIV infection is evolving—a lower proportion of time is now spent managing drug resistance and short term toxicities and a higher proportion is spent managing these premature age associated complications. This review discusses the evidence that the major complications of “treated” HIV disease—including cardiovascular disease, malignancy, renal disease, …

Integrity signals

Registry

Crossref · 10.1136/bmj.a3172

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Microbial translocation is a cause of systemic immune activation in chronic HIV infection
Brenchley, J. M., Price, D. A., Schacker, T. W., Asher, T. E., Silvestri, G., Rao, S., Kazzaz, Z., Bornstein, E., Lambotte, O., Altmann, D., et al. (2006) · Nature Medicine · doi:10.1038/nm1511 · Cited by 3,559
CD4+ Count–Guided Interruption of Antiretroviral Treatment
The Strategies for Management of Antiretroviral Therapy (SMART) Study Group (2006) · New England Journal of Medicine · doi:10.1056/nejmoa062360 · Cited by 2,250
Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies.
(2008) · The Lancet · doi:10.1016/s0140-6736(08)61113-7 · Cited by 1,661
. Inflammatory and coagulation biomarkers and mortality in patients with HIV infection.
Kuller, L. H., Tracy, R., Belloso, W., Wit, S. D., Drummond, F., Lane, H. C., Ledergerber, B., Lundgren, J., Neuhaus, J., Nixon, D., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050203 · Cited by 1,617
Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease
Triant, V. A., Lee, H., Hadigan, C., & Grinspoon, S. K. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2190 · Cited by 1,613
Class of Antiretroviral Drugs and the Risk of Myocardial Infarction
(2007) · New England Journal of Medicine · doi:10.1056/nejmoa062744 · Cited by 1,521
Liver-Related Deaths in Persons Infected With the Human Immunodeficiency Virus
The Data Collection on Adverse Events of Anti-HIV Drugs Study Group* (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.15.1632 · Cited by 1,115
Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the D:A:D study: a multi-cohort collaboration
‡ (2008) · The Lancet · doi:10.1016/s0140-6736(08)60423-7 · Cited by 918
T Cell Activation Is Associated with Lower CD4+T Cell Gains in Human Immunodeficiency Virus–Infected Patients with Sustained Viral Suppression during Antiretroviral Therapy
Hunt, P. W., Martin, J. N., Sinclair, E., Bredt, B. M., Hagos, E., Lampiris, H. W., & Deeks, S. G. (2003) · The Journal of Infectious Diseases · doi:10.1086/374786 · Cited by 852
. Survival of persons with and without HIV infection in Denmark, 1995-2005.
Lohse, N., Hansen, A.-B. E., Pedersen, G., Kronborg, G., Gerstoft, J., Sørensen, H. T., Væth, M., & Obel, N. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-2-200701160-00003 · Cited by 748

Show all 25 references

Sorted by citations

Circulating microRNAs in Sera Correlate with Soluble Biomarkers of Immune Activation but Do Not Predict Mortality in ART Treated Individuals with HIV-1 Infection: A Case Control Study
Murray, D. D., Suzuki, K., Law, M. G., Trebicka, J., Neuhaus, J., Wentworth, D. N., Johnson, M. A., Vjecha, M. J., Kelleher, A. D., Emery, S., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139981 · Cited by 2,740
The end of AIDS: HIV infection as a chronic disease
Deeks, S. G., Lewin, S. R., & Havlir, D. V. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61809-7 · Cited by 2,081
. Premature Age-Related Comorbidities Among HIV-Infected Persons Compared with the General Population.
Guaraldi, G., Orlando, G., Zona, S., Menozzi, M., Carli, F., Garlassi, E., Berti, A., Rossi, E., Roverato, A., & Palella, F. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir627 · Cited by 1,331
Cross-sectional Comparison of the Prevalence of Age-Associated Comorbidities and Their Risk Factors Between HIV-Infected and Uninfected Individuals: The AGEhIV Cohort Study
Schouten, J., Wit, F. W. N. M., Stolte, I. G., Kootstra, N. A., van der Valk, M., Geerlings, S. E., Prins, M., Reiss, P., for the AGEhIV Cohort Study Group, Reiss, P., et al. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu701 · Cited by 773
Morbidity and Aging in HIV-Infected Persons: The Swiss HIV Cohort Study
Hasse, B. K., Ledergerber, B., Furrer, H., Battegay, M., Hirschel, B. J., Cavassini, M. L., Bertisch, B., Bernasconi, E., Weber, R. K., & Study, T. S. H. C. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir626 · Cited by 608
Causes of Death in HIV‐1–Infected Patients Treated with Antiretroviral Therapy, 1996–2006: Collaborative Analysis of 13 HIV Cohort Studies
The Antiretroviral Therapy Cohort Collaboration (2010) · Clinical Infectious Diseases · doi:10.1086/652283 · Cited by 592
Effect of immunodeficiency, HIV viral load, and antiretroviral therapy on the risk of individual malignancies (FHDH-ANRS CO4): a prospective cohort study
Guiguet, M., Boué, F., Cadranel, J. L., Lang, J.-M., Rosenthal, É., & Costagliola, D. G. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70282-7 · Cited by 561
HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group
High, K. P., Brennan-Ing, M., Clifford, D. B., Cohen, M. H., Currier, J., Deeks, S. G., Deren, S., Effros, R. B., Gebo, K., Goronzy, J. J., et al. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31825a3668 · Cited by 522
Self-citation
Antiretroviral therapy and management of HIV infection
Volberding, P. A., & Deeks, S. G. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60676-9 · Cited by 461
Frailty as a Novel Predictor of Mortality and Hospitalization in Individuals of All Ages Undergoing Hemodialysis
McAdams‐DeMarco, M., Law, A. H., Salter, M. L., Boyarsky, B. J., Giménez, L., Jaar, B. G., Walston, J. D., & Segev, D. L. (2013) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12266 · Cited by 449
Projected life expectancy of people with HIV according to timing of diagnosis
Nakagawa, F., Lodwick, R. K., Smith, C. J., Smith, R. D., Cambiano, V., Lundgren, J. D., Delpech, V., & Phillips, A. N. (2011) · AIDS · doi:10.1097/qad.0b013e32834dcec9 · Cited by 444
Is HIV a Model of Accelerated or Accentuated Aging?
Pathai, S., Bajillan, H., LANDAY, A. L., & High, K. P. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt168 · Cited by 437
HIV Infection and Risk for Incident Pulmonary Diseases in the Combination Antiretroviral Therapy Era
Crothers, K. A., Huang, L., Goulet, J. L., Goetz, M. B., Brown, S. T., Rodriguez‐Barradas, M. C., Oursler, K. K., Rimland, D., Gibert, C. L., Butt, A. A., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201006-0836oc · Cited by 417
Mortality and causes of death in people diagnosed with HIV in the era of highly active antiretroviral therapy compared with the general population: an analysis of a national observational cohort
Croxford, S., Kitching, A., Desai, S., Kall, M. M., Edelstein, M. L., Skingsley, A., Burns, F. M., Copas, A. J., Brown, A. E., Sullivan, A. K., et al. (2016) · The Lancet Public Health · doi:10.1016/s2468-2667(16)30020-2 · Cited by 400
Life expectancy living with HIV
Nakagawa, F., May, M., & Phillips, A. N. (2012) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e32835ba6b1 · Cited by 374
Co-Morbidities in Persons Infected with HIV: Increased Burden with Older Age and Negative Effects on Health-Related Quality of Life
Rodriguez-Penney, A. T., Iudicello, J. E., Riggs, P. K., Doyle, K. L., Ellis, R. J., Letendre, S. L., Grant, I., & Woods, A. T. H. N. S. P. (2013) · AIDS Patient Care and STDs · doi:10.1089/apc.2012.0329 · Cited by 323
HIV and aging: time for a new paradigm.
Justice, A. C. (2010) · Current HIV/AIDS Reports · doi:10.1007/s11904-010-0041-9 · Cited by 309
Increased risk of myocardial infarction in HIV-infected patients in France, relative to the general population
Lang, S., Mary‐Krause, M., Cotte, L., Gilquin, J., Partisani, M., Simon, A., Boccara, F., Bingham, A., & Costagliola, D. G. (2010) · AIDS · doi:10.1097/qad.0b013e328339192f · Cited by 297
Global and regional trends of people living with HIV aged 50 and over: Estimates and projections for 2000–2020
Autenrieth, C. S., Beck, E. J., Stelzle, D., Mallouris, C., Mahy, M. I., & Ghys, P. D. (2018) · PLoS ONE · doi:10.1371/journal.pone.0207005 · Cited by 287
Serious Fatal and Nonfatal Non-AIDS-Defining Illnesses in Europe
Mocroft, A., Reiss, P., Gąsiorowski, J., Ledergerber, B., Kowalska, J. D., Chiesi, A., Gatell, J. M., Rakhmanova, A. G., Johnson, M. A., Kirk, O., et al. (2010) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3181e9be6b · Cited by 271
Noncommunicable diseases among HIV-infected persons in low-income and middle-income countries
Patel, P., Rose, C. E., Collins, P. Y., Nuche‐Berenguer, B., Sahasrabuddhe, V. V., Peprah, E. K., Vorkoper, S., Pastakia, S. D., Rausch, D. M., & Levitt, N. S. (2018) · AIDS · doi:10.1097/qad.0000000000001888 · Cited by 281
Immunologic Basis of Cardiovascular Disease in HIV-Infected Adults
Hsue, P. Y., Deeks, S. G., & Hunt, P. W. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis200 · Cited by 281
Immune aging, dysmetabolism, and inflammation in neurological diseases
Deleidi, M., JÃ¤ggle, M., & Rubino, G. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00172 · Cited by 260
Early Immune Senescence in HIV Disease
Desai, S. N., & LANDAY, A. L. (2010) · Current HIV/AIDS Reports · doi:10.1007/s11904-009-0038-4 · Cited by 252
The Next Therapeutic Challenge in HIV: Polypharmacy
Edelman, E. J., Gordon, K. S., Glover, J. G., McNicholl, I. R., Fiellin, D. A., & Justice, A. C. (2013) · Drugs & Aging · doi:10.1007/s40266-013-0093-9 · Cited by 232
Biomarkers of immune dysfunction in HIV
Nixon, D. E., & LANDAY, A. L. (2010) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e32833ed6f4 · Cited by 223
The split personality of regulatory T cells in HIV infection
Chevalier, M. F., & Weiss, L. (2012) · Blood · doi:10.1182/blood-2012-07-409755 · Cited by 227
Growing Older With HIV/AIDS: New Public Health Challenges
Cahill, S., & Valadéz, R. (2013) · American Journal of Public Health · doi:10.2105/ajph.2012.301161 · Cited by 228
Does an Index Composed of Clinical Data Reflect Effects of Inflammation, Coagulation, and Monocyte Activation on Mortality Among Those Aging With HIV?
Justice, A. C., Freiberg, M. S., Tracy, R. P., Kuller, L. H., Tate, J., Goetz, M. B., Fiellin, D. A., Vanasse, G. J., Butt, A. A., Rodriguez‐Barradas, M. C., et al. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cir989 · Cited by 204
HIV Infection and Older Americans: The Public Health Perspective
Brooks, J. T., Buchacz, K. A., Gebo, K. A., & Mermin, J. (2012) · American Journal of Public Health · doi:10.2105/ajph.2012.300844 · Cited by 204
Gut epithelial barrier and systemic inflammation during chronic HIV infection
Somsouk, M., Estes, J. D., Deléage, C., Dunham, R. M., Albright, R. G., Inadomi, J. M., Martin, J. N., Deeks, S. G., McCune, J. M., & Hunt, P. W. (2014) · AIDS · doi:10.1097/qad.0000000000000511 · Cited by 203
An internationally generalizable risk index for mortality after one year of antiretroviral therapy
Tate, J. P., Justice, A. C., Hughes, M. D., Bonnet, F., Reiss, P., Mocroft, A., Nattermann, J., Lampe, F. C., Bucher, H. C., Sterling, T. R., et al. (2012) · AIDS · doi:10.1097/qad.0b013e32835b8c7f · Cited by 201
Cumulative and current exposure to potentially nephrotoxic antiretrovirals and development of chronic kidney disease in HIV-positive individuals with a normal baseline estimated glomerular filtration rate: a prospective international cohort study
Mocroft, A., Lundgren, J. D., Ross, M. J., Fux, C. A., Reiss, P., Moranne, O. P., Morlat, P., Monforte, A. D., Kirk, O., & Ryom, L. (2015) · The Lancet HIV · doi:10.1016/s2352-3018(15)00211-8 · Cited by 198
Cytomegalovirus Coinfection Is Associated With an Increased Risk of Severe Non–AIDS-Defining Events in a Large Cohort of HIV-Infected Patients
Lichtner, M., Cicconi, P., Vita, S., Cozzi‐Lepri, A., Galli, M., Caputo, S. L., Saracino, A., Luca, A. D., Moioli, M. C., Maggiolo, F., et al. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu417 · Cited by 194
Increase in 2–Long Terminal Repeat Circles and Decrease in D-dimer After Raltegravir Intensification in Patients With Treated HIV Infection: A Randomized, Placebo-Controlled Trial
Hatano, H., Strain, M. C., Scherzer, R., Bacchetti, P., Wentworth, D. N., Hoh, R., Martin, J. N., McCune, J. M., Neaton, J. D., Tracy, R. P., et al. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit453 · Cited by 172
Pathogenesis of HIV-Related Lung Disease: Immunity, Infection, and Inflammation
Cribbs, S. K., Crothers, K. A., & Morris, A. (2019) · Physiological Reviews · doi:10.1152/physrev.00039.2018 · Cited by 175
Immune restoration after antiretroviral therapy: the pitfalls of hasty or incomplete repairs
Wilson, E. M. P., & Sereti, I. (2013) · Immunological Reviews · doi:10.1111/imr.12064 · Cited by 176
DCAF1 regulates Treg senescence via the ROS axis during immunological aging
Guo, Z., Wang, G., Wu, B., Chou, W.-C., Cheng, L., Zhou, C., Lou, J., Wu, D., Su, L., Zheng, J., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci136466 · Cited by 163
The CD4/CD8 ratio as a marker T-cell activation, senescence and activation/exhaustion in treated HIV-infected children and young adults
Sainz, T., Villar, S. S., Díaz, L., Tomé, M. I. G., Gurbindo, M. D., de José, M. I., Mellado, M. J., Ramos, J. T., Zamora, J., Moreno, S., et al. (2013) · AIDS · doi:10.1097/qad.0b013e32835faa72 · Cited by 160
The CD4/CD8 ratio in HIV-infected subjects is independently associated with T-cell activation despite long-term viral suppression
Villar, S. S., Gutiérrez, C., Vallejo, A., Hernández‐Novoa, B., Díaz, L., Abad-Fernández, M., Madrid, N., Dronda, F., Zamora, J., Muñoz‐Fernández, M. Á., et al. (2012) · Journal of Infection · doi:10.1016/j.jinf.2012.09.013 · Cited by 159
Immunosenescence and HIV
Deeks, S. G., Verdin, E. M., & McCune, J. M. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.05.004 · Cited by 169
HIV-ASSOCIATED VENOUS THROMBOEMBOLISM
Bibas, M., Biava, G., & Antinori, A. (2011) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2011.030 · Cited by 158
Increased Risk of Myocardial Infarction in HIV-Infected Individuals in North America Compared With the General Population
Drozd, D. R., Kitahata, M. M., Althoff, K. N., Zhang, J., Gange, S. J., Napravnik, S., Burkholder, G., Mathews, W. C., Silverberg, M. J., Sterling, T. R., et al. (2017) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000001450 · Cited by 156
The CD 4: CD 8 ratio is associated with markers of age‐associated disease in virally suppressed HIV ‐infected patients with immunological recovery
Villar, S. S., Moreno, S., Fuentes, M. E., Sánchez, C., Ávila, M., Sainz, T., de Villar, N., Fernández‐Cruz, A., & Estrada, V. (2013) · HIV Medicine · doi:10.1111/hiv.12081 · Cited by 155
Evidence for Innate Immune System Activation in HIV Type 1–Infected Elite Controllers
Krishnan, S., Wilson, E. M. P., Sheikh, V., Rupert, A. W., Mendoza, D., Yang, J., Lempicki, R. A., Migueles, S. A., & Sereti, I. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit581 · Cited by 146
Impact of Non-HIV and HIV Risk Factors on Survival in HIV-Infected Patients on HAART: A Population-Based Nationwide Cohort Study
Obel, N., Omland, L. H., Kronborg, G., Larsen, C. S., Pedersen, C., Pedersen, G., Sørensen, H. T., & Gerstoft, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022698 · Cited by 145
Inhibition of telomerase activity by human immunodeficiency virus (HIV) nucleos(t)ide reverse transcriptase inhibitors: a potential factor contributing to HIV-associated accelerated aging
Leeansyah, E., Cameron, P. U., Solomon, A., Tennakoon, S., Velayudham, P., Gouillou, M., Spelman, T., Hearps, A., Fairley, C., Smit, D. V., et al. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit006 · Cited by 136
Level of Adherence and HIV RNA Suppression in the Current Era of Highly Active Antiretroviral Therapy (HAART)
Viswanathan, S., Detels, R., Mehta, S. H., Macatangay, B. J. C., Kirk, G. D., & Jacobson, L. P. (2014) · AIDS and Behavior · doi:10.1007/s10461-014-0927-4 · Cited by 139
Premature and accelerated aging: HIV or HAART?
Smith, R. L., de Boer, R., Brul, S., Budovskaya, Y. V., & van der Spek, H. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2012.00328 · Cited by 138
Premature Decline of Serum Total Testosterone in HIV-Infected Men in the HAART-Era
Rochira, V., Zirilli, L., Orlando, G., Santi, D., Brigante, G., Diazzi, C., Carli, F., Carani, C., & Guaraldi, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028512 · Cited by 137
The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T-cell recovery: a randomized trial
Hunt, P. W., Shulman, N. S., Hayes, T. L., Dahl, V., Somsouk, M., Funderburg, N., McLaughlin, B. E., LANDAY, A. L., Adeyemi, O. M., Gilman, L. T., et al. (2013) · Blood · doi:10.1182/blood-2012-06-436345 · Cited by 138
Immune activation, apoptosis, and Treg activity are associated with persistently reduced CD4+ T-cell counts during antiretroviral therapy
Piconi, S., Trabattoni, D., Gori, A., Parisotto, S., Magni, C. F., Meraviglia, P., Bandera, A., Capetti, A. F., Rizzardini, G., & Clerici, M. (2010) · AIDS · doi:10.1097/qad.0b013e32833c93ce · Cited by 137
HIV cure and eradication: how will we get from the laboratory to effective clinical trials?
Lewin, S. R., & Rouzioux, C. (2011) · AIDS · doi:10.1097/qad.0b013e3283467041 · Cited by 133
The lifetime medical cost savings from preventing HIV in the United States
Schackman, B. R., Fleishman, J. A., Su, A. E., Berkowitz, B. K., Moore, R. D., Walensky, R. P., Becker, J. E., Voss, C., Paltiel, A. D., Weinstein, M. C., et al. (2015) · Medical Care · doi:10.1097/mlr.0000000000000308 · Cited by 123
Experienced discrimination and racial differences in leukocyte gene expression
Thames, A. D., Irwin, M. R., Breen, E. C., & Cole, S. W. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.04.016 · Cited by 125
mRNA transfection of a novel TAL effector nuclease (TALEN) facilitates efficient knockout of HIV co-receptor CCR5
Mock, U., Machowicz, R., Hauber, I., Horn, S., Abramowski, P., Berdien, B., Hauber, J., & Fehse, B. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv469 · Cited by 129
HIV-Associated Immune Activation: From Bench to Bedside
d’Ettorre, G., Paiardini, M., Ceccarelli, G., Silvestri, G., & Vullo, V. (2011) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2010.0342 · Cited by 124
Cerebrospinal fluid metabolomics reveals altered waste clearance and accelerated aging in HIV patients with neurocognitive impairment
Cassol, E., Misra, V., Dutta, A., Morgello, S., & Gabuzda, D. H. (2014) · AIDS · doi:10.1097/qad.0000000000000303 · Cited by 127
HIV-infected persons continue to lose kidney function despite successful antiretroviral therapy
Choi, A. I., Shlipak, M. G., Hunt, P. W., Martin, J. N., & Deeks, S. G. (2009) · AIDS · doi:10.1097/qad.0b013e3283313c91 · Cited by 121
Projections of non-communicable disease and health care costs among HIV-positive persons in Italy and the U.S.A.: A modelling study
Smit, M., Cassidy, R., Cozzi‐Lepri, A., Quirós-Roldán, E., Girardi, E., Mammone, A., Antinori, A., Saracino, A., Bai, F., Rusconi, S., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186638 · Cited by 122
Disparities in Prevalence of Key Chronic Diseases by Gender and Race/Ethnicity among Antiretroviral-Treated HIV-Infected Adults in the Us
Buchacz, K. A., Baker, R. K., Palella, F. J., Shaw, L., Patel, P., Lichtenstein, K. A., Chmiel, J. S., Vellozzi, C. J., Debes, R., Henry, K., et al. (2012) · Antiviral Therapy · doi:10.3851/imp2450 · Cited by 126
Premature Aging and Premature Age-Related Comorbidities in HIV-Infected Patients: Facts and Hypotheses
Capeau, J. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir628 · Cited by 125
Expert consensus statement on the science of HIV in the context of criminal law
Barré‐Sinoussi, F., Karim, S. S. A., Albert, J., Bekker, L., Beyrer, C., Cahn, P. E., Calmy, A., Grinsztejn, B. G. J., Grulich, A. E., Kamarulzaman, A., et al. (2018) · Journal of the International AIDS Society · doi:10.1002/jia2.25161 · Cited by 124
Basic science and pathogenesis of ageing with HIV
Lagathu, C., Cossarizza, A., Béréziat, V., Nasi, M., Capeau, J., & Pinti, M. (2017) · AIDS · doi:10.1097/qad.0000000000001441 · Cited by 114
Hypertension control in integrated HIV and chronic disease clinics in Uganda in the SEARCH study
Kwarisiima, D., Atukunda, M., Owaraganise, A., Chamie, G., Clark, T. D., Kabami, J., Jain, V., Byonanebye, D. M., Mwangwa, F., Balzer, L. B., et al. (2019) · BMC Public Health · doi:10.1186/s12889-019-6838-6 · Cited by 110
The Incidence of AIDS-Defining Illnesses at a Current CD4 Count >=200 Cells/ L in the Post-Combination Antiretroviral Therapy Era
Mocroft, A., Furrer, H., Miro, J. M., Reiss, P., Mussini, C., Kirk, O., Abgrall, S., Ayayi, S., Bartmeyer, B., Braun, D., et al. (2013) · doi:10.7892/boris.44212 · Cited by 110
Physical activity correlates in people living with HIV/AIDS: a systematic review of 45 studies
Vancampfort, D., Mugisha, J., Richards, J. A., Binder, M. D., Probst, M., & Stubbs, B. (2017) · Disability and Rehabilitation · doi:10.1080/09638288.2017.1306587 · Cited by 109
Nevirapine versus Atazanavir/Ritonavir, Each Combined with Tenofovir Disoproxil Fumarate/Emtricitabine, in Antiretroviral-Naive HIV-1 Patients: The Arten Trial
ARTEN investigators, Soriano, V., Arastéh, K., Migrone, H., Lutz, T., Opravil, M., Andrade-Villanueva, J. F., Antunes, F., Perri, G. D., Podzamczer, D., et al. (2010) · Antiviral Therapy · doi:10.3851/imp1745 · Cited by 108
HIV-1 infection induces strong production of IP-10 through TLR7/9-dependent pathways
Simmons, R. P., Scully, E. P., Groden, E. E., Arnold, K. B., Chang, J. J., Lane, K., Lifson, J. D., Rosenberg, E. S., Lauffenburger, D. A., & Altfeld, M. A. (2013) · AIDS · doi:10.1097/01.aids.0000432455.06476.bc · Cited by 106
Association Between Short Leukocyte Telomere Length and HIV Infection in a Cohort Study: No Evidence of a Relationship With Antiretroviral Therapy
Zanet, D. L., Thorne, A., Singer, J., Maan, E. J., Sattha, B., Campion, A. L., Soudeyns, H., Pick, N., Murray, M. C. M., Money, D., et al. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu051 · Cited by 106
Targeting the Brain Reservoirs: Toward an HIV Cure
Marban, C., Forouzanfar, F., Aït-Ammar, A., Fahmi, F., Mekdad, H. E., Daouad, F., Rohr, O., & Schwartz, C. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00397 · Cited by 110
Markers of coagulation and inflammation often remain elevated in ART-treated HIV-infected patients
Funderburg, N. (2013) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000019 · Cited by 105
Targeting of mTOR catalytic site inhibits multiple steps of the HIV-1 lifecycle and suppresses HIV-1 viremia in humanized mice
Heredia, A., Le, N. M., Gartenhaus, R. B., Sausville, E. A., Medina-Moreno, S., Zapata, J. C., Davis, C. E. L. B., Gallo, R. C., & Redfield, R. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1511144112 · Cited by 104
Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV
Alrubayyi, A., Gea‐Mallorquí, E., Touizer, E., Hameiri‐Bowen, D., Kopycinski, J. T., Charlton, B. G., Fisher-Pearson, N., Muir, L., Rosa, A., Roustan, C., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26137-7 · Cited by 107
HIV-Associated Lung Infections and Complications in the Era of Combination Antiretroviral Therapy
Crothers, K. A., Thompson, B. W., Burkhardt, K., Morris, A. M., Flores, S. C., Diaz, P. T., Chaisson, R. E., Kirk, G. D., Rom, W. N., & Huang, L. (2011) · Proceedings of the American Thoracic Society · doi:10.1513/pats.201009-059wr · Cited by 101
Therapeutic Immunization with HIV-1 Tat Reduces Immune Activation and Loss of Regulatory T-Cells and Improves Immune Function in Subjects on HAART
Ensoli, B., Bellino, S., Tripiciano, A., Longo, O., Francavilla, V., Marcotullio, S., Cafaro, A., Picconi, O., Paniccia, G., Scoglio, A., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013540 · Cited by 97
Chronic Disease Onset Among People Living with HIV and AIDS in a Large Private Insurance Claims Dataset
Yang, H.-Y., Beymer, M. R., & Suen, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-54969-3 · Cited by 97
Hypogonadism in the HIV-infected man
Rochira, V., & Guaraldi, G. (2014) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2014.06.005 · Cited by 95
In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and "kill" in strategy for virus eradication
Marsden, M. D., Loy, B. A., Wu, X., Ramirez, C. M., Schrier, A. J., Murray, D., Shimizu, A., Ryckbosch, S. M., Near, K. E., Chun, T., et al. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006575 · Cited by 94
An active lifestyle is associated with better neurocognitive functioning in adults living with HIV infection
the HNRP Group, Fazeli, P. L., Woods, S. P., Heaton, R. K., Umlauf, A., Gouaux, B. D., Cookson, D. R., Moore, R. C., Grant, I., & Moore, D. J. (2014) · Journal of NeuroVirology · doi:10.1007/s13365-014-0240-z · Cited by 88
Clonal Sequences Recovered from Plasma from Patients with Residual HIV-1 Viremia and on Intensified Antiretroviral Therapy Are Identical to Replicating Viral RNAs Recovered from Circulating Resting CD4 + T Cells
Anderson, J. A., Archin, N. M., Ince, W., Parker, D., Wiegand, A. P., Coffin, J. M., Kuruc, J. D., Eron, J. J., Swanstrom, R. I., & Margolis, D. M. (2011) · Journal of Virology · doi:10.1128/jvi.00284-11 · Cited by 86
Definition of Advanced Age in HIV Infection: Looking for an Age Cut-Off
Blanco, J. R., Jarrín, I., Vallejo, M., Berenguer, J., Solera, C., Rubio, R., Pulido, F., Asensi, V., del Amo, J., & Moreno, A. C. S. (2012) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2011.0377 · Cited by 85
Comorbidities in people living with HIV: An epidemiologic and economic analysis using a claims database in France
Pourcher, V., Gourmelen, J., Bureau, I., & Bouée, S. (2020) · PLoS ONE · doi:10.1371/journal.pone.0243529 · Cited by 83
Association of Viral Suppression With Lower AIDS-Defining and Non–AIDS-Defining Cancer Incidence in HIV-Infected Veterans
Park, L. S., Tate, J. P., Sigel, K. M., Brown, S. T., Crothers, K. A., Gibert, C. L., Goetz, M. B., Rimland, D., Rodriguez‐Barradas, M. C., Bedimo, R., et al. (2018) · Annals of Internal Medicine · doi:10.7326/m16-2094 · Cited by 84
Immunodeficiency and the risk of serious clinical endpoints in a well studied cohort of treated HIV-infected patients
Achhra, A. C., Amin, J., Law, M. G., Emery, S., Gerstoft, J., Gordin, F. M., Vjecha, M. J., Neaton, J. D., & Cooper, D. A. (2010) · AIDS · doi:10.1097/qad.0b013e32833b1b26 · Cited by 83
Circulating (1→3)-β-D-glucan Is Associated With Immune Activation During Human Immunodeficiency Virus Infection
Mehraj, V., Ramendra, R., Isnard, S., Dupuy, F. P., Ponte, R., Chen, J., Kema, I. P., Jenabian, M.-A., Costiniuk, C. T., Lebouché, B., et al. (2019) · Clinical Infectious Diseases · doi:10.1093/cid/ciz212 · Cited by 87
Influence of the Timing of Antiretroviral Therapy on the Potential for Normalization of Immune Status in Human Immunodeficiency Virus 1–Infected Individuals
Okulicz, J. F., Le, T. D., Agan, B. K., Camargo, J. F., Landrum, M. L., Wright, E., Dolan, M. J., Ganesan, A., Ferguson, T. M., Smith, D. M., et al. (2014) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2014.4010 · Cited by 83
Antiretroviral exposure and comorbidities in an aging HIV-infected population: The challenge of geriatric patients
Allavena, C., Hanf, M., Rey, D., Duvivier, C., Bani‐Sadr, F., Poizot‐Martin, I., Jacomet, C., Puglièse, P., Delobel, P., Katlama, C., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0203895 · Cited by 82
The Dual Impact of HIV-1 Infection and Aging on Naïve CD4+ T-Cells: Additive and Distinct Patterns of Impairment
Rickabaugh, T. M., Kilpatrick, R. D., Hultin, L. E., Hultin, P. M., Hausner, M. A., Sugar, C. A., Althoff, K. N., Margolick, J. B., Rinaldo, C. R., Detels, R., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016459 · Cited by 83
Beyond the replication-competent HIV reservoir: transcription and translation-competent reservoirs
Baxter, A. E., O’Doherty, U., & Kaufmann, D. (2018) · Retrovirology · doi:10.1186/s12977-018-0392-7 · Cited by 81
Dimethyl Fumarate Modulation of Immune and Antioxidant Responses: Application to HIV Therapy
Gill, A. J., & Kolson, D. L. (2013) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2013007247 · Cited by 81
Th17, gut, and HIV: therapeutic implications
Hunt, P. W. (2010) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e32833647d9 · Cited by 82
The Veterans Aging Cohort Study Index is Associated With Concurrent Risk for Neurocognitive Impairment
Marquine, M. J., Umlauf, A., Rooney, A. S., Fazeli, P. L., Gouaux, B. D., Woods, S. P., Letendre, S. L., Ellis, R. J., Grant, I., & Moore, D. J. (2013) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000000008 · Cited by 78
Immune Activation and Collateral Damage in AIDS Pathogenesis
Miedema, F. F., Hazenberg, M. D., Tesselaar, K., van Baarle, D., de Boer, R. J., & Borghans, J. A. M. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00298 · Cited by 79
Updating the Free Radical Theory of Aging
Ziada, A. S., Smith, M.-S. R., & Côté, H. C. F. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.575645 · Cited by 87
Residual immune dysfunction under antiretroviral therapy
Cai, C. W., & Sereti, I. (2021) · Seminars in Immunology · doi:10.1016/j.smim.2021.101471 · Cited by 80
High frequency of poor locomotor performance in HIV-infected patients
Richert, L. E., Dehail, P., Mercié, P., Dauchy, F., Bruyand, M., Greib, C., Dabis, F., Bonnet, F., & Chêne, G. (2011) · AIDS · doi:10.1097/qad.0b013e3283455dff · Cited by 78
The Many Faces of Immune Activation in HIV-1 Infection: A Multifactorial Interconnection
Mazzuti, L., Turriziani, O., & Mezzaroma, I. (2023) · Biomedicines · doi:10.3390/biomedicines11010159 · Cited by 77
Galectin-9 Is Rapidly Released During Acute HIV-1 Infection and Remains Sustained at High Levels Despite Viral Suppression Even in Elite Controllers
Tandon, R., Chew, G. M., Byron, M. M., Borrow, P., Niki, T., Hirashima, M., Barbour, J. D., Norris, P. J., Lanteri, M. C., Martin, J. N., et al. (2014) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2014.0004 · Cited by 77
Building on the HIV chronic care platform to address noncommunicable diseases in sub-Saharan Africa
Vorkoper, S., Kupfer, L. E., Anand, N. P., Patel, P., Beecroft, B., Tierney, W. M., Ferris, R., & El-Sadr, W. M. (2018) · AIDS · doi:10.1097/qad.0000000000001898 · Cited by 76

Authors: Deeks, S. G., & Phillips, A. N.
Affiliations: San Francisco General Hospital (US)
The Royal Free Hospital (GB)
Corresponding author: Deeks, S. G
ORCID: Phillips, A. N
Venue: BMJ
Publisher: BMJ
Published: 2009-01-26
Volume: 338
Issue: jan26 2
Pages: a3172-a3172
ISSN: 0007-1447 (ISSN-L)
0959-8138
1468-5833
DOI: 10.1136/bmj.a3172
OpenAlex: W2110559078
Cited by: 704
References: 25
Citations by year: 2026: 14 · 2025: 14 · 2024: 22 · 2023: 27 · 2022: 36 · 2021: 38 · 2020: 37 · 2019: 48 · 2018: 47 · 2017: 48 · 2016: 46 · 2015: 71 · 2014: 57 · 2013: 61 · 2012: 53
FWCI: 47.39
Type: journal article
Language: en
Open access: closed
Locations: BMJ (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Keywords: HIV infection, antiretroviral therapy, aging, CD4 count, cardiovascular disease, HIV-associated malignancies, kidney disease, drug resistance, long-term viral suppression
MeSH terms: Age Factors, Cardiovascular Diseases, Health Status, Humans, Kidney Diseases, Liver Diseases, Neoplasms, Risk Factors, HIV Infections, Treatment Outcome, CD4 Lymphocyte Count, Anti-HIV Agents

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

HIV infection, antiretroviral treatment, ageing, and non-AIDS related morbidity.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks