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HIV infection, antiretroviral treatment, ageing, and non-AIDS related morbidity.
Abstract
#### Summary points More than 25 antiretroviral drugs from six therapeutic classes are now available for the management of HIV infection (box 1). Most patients who take medication achieve durable and perhaps lifelong viral suppression, so the classic AIDS related conditions are becoming less common. However, treated patients do not have completely restored health. Compared with people without HIV infection, patients with the infection who are treated with antiretrovirals have increased risk for several “non-AIDS” complications, many of which are commonly associated with ageing (box 2). This risk is particularly evident in patients whose CD4+ T cell counts are below normal during long term treatment, but it is also seen to some extent in those with higher CD4+ T cell counts. As a consequence of the changing spectrum of HIV associated disease, the medical management of HIV infection is evolving—a lower proportion of time is now spent managing drug resistance and short term toxicities and a higher proportion is spent managing these premature age associated complications. This review discusses the evidence that the major complications of “treated” HIV disease—including cardiovascular disease, malignancy, renal disease, …
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From HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group (2012) · cites this paper as [68]
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Metadata
- Authors
- Deeks, S. G., & Phillips, A. N.
- Affiliations
- San Francisco General Hospital (US)
- The Royal Free Hospital (GB)
- Corresponding author
- Deeks, S. G
- ORCID
- Phillips, A. N
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2009-01-26
- Volume
- 338
- Issue
- jan26 2
- Pages
- a3172-a3172
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- OpenAlex
- W2110559078
- Cited by
- 704
- References
- 25
- Citations by year
- 2026: 14 · 2025: 14 · 2024: 22 · 2023: 27 · 2022: 36 · 2021: 38 · 2020: 37 · 2019: 48 · 2018: 47 · 2017: 48 · 2016: 46 · 2015: 71 · 2014: 57 · 2013: 61 · 2012: 53
- FWCI
- 47.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- BMJ (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Keywords
- HIV infection, antiretroviral therapy, aging, CD4 count, cardiovascular disease, HIV-associated malignancies, kidney disease, drug resistance, long-term viral suppression
- MeSH terms
- Age Factors, Cardiovascular Diseases, Health Status, Humans, Kidney Diseases, Liver Diseases, Neoplasms, Risk Factors, HIV Infections, Treatment Outcome, CD4 Lymphocyte Count, Anti-HIV Agents
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