The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
HIV infection, antiretroviral treatment, ageing, and non-AIDS related morbidity.
Abstract
#### Summary points More than 25 antiretroviral drugs from six therapeutic classes are now available for the management of HIV infection (box 1). Most patients who take medication achieve durable and perhaps lifelong viral suppression, so the classic AIDS related conditions are becoming less common. However, treated patients do not have completely restored health. Compared with people without HIV infection, patients with the infection who are treated with antiretrovirals have increased risk for several “non-AIDS” complications, many of which are commonly associated with ageing (box 2). This risk is particularly evident in patients whose CD4+ T cell counts are below normal during long term treatment, but it is also seen to some extent in those with higher CD4+ T cell counts. As a consequence of the changing spectrum of HIV associated disease, the medical management of HIV infection is evolving—a lower proportion of time is now spent managing drug resistance and short term toxicities and a higher proportion is spent managing these premature age associated complications. This review discusses the evidence that the major complications of “treated” HIV disease—including cardiovascular disease, malignancy, renal disease, …
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, as among those without HIV infection, a likely driving force behind this vulnerability to injury is chronic inflammation (67–69).”
From HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group (2012) · cites this paper as [68]
Citations
Cites
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
Brenchley, J. M., Price, D. A., Schacker, T. W., Asher, T. E., Silvestri, G., Rao, S., Kazzaz, Z., Bornstein, E., Lambotte, O., Altmann, D., et al. (2006) · Nature Medicine · doi:10.1038/nm1511 · Cited by 3,559
CD4+ Count–Guided Interruption of Antiretroviral Treatment
The Strategies for Management of Antiretroviral Therapy (SMART) Study Group (2006) · New England Journal of Medicine · doi:10.1056/nejmoa062360 · Cited by 2,250
. Inflammatory and coagulation biomarkers and mortality in patients with HIV infection.
Kuller, L. H., Tracy, R., Belloso, W., Wit, S. D., Drummond, F., Lane, H. C., Ledergerber, B., Lundgren, J., Neuhaus, J., Nixon, D., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050203 · Cited by 1,617
Triant, V. A., Lee, H., Hadigan, C., & Grinspoon, S. K. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2190 · Cited by 1,613
Class of Antiretroviral Drugs and the Risk of Myocardial Infarction
(2007) · New England Journal of Medicine · doi:10.1056/nejmoa062744 · Cited by 1,521
Liver-Related Deaths in Persons Infected With the Human Immunodeficiency Virus
The Data Collection on Adverse Events of Anti-HIV Drugs Study Group* (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.15.1632 · Cited by 1,115
Hunt, P. W., Martin, J. N., Sinclair, E., Bredt, B. M., Hagos, E., Lampiris, H. W., & Deeks, S. G. (2003) · The Journal of Infectious Diseases · doi:10.1086/374786 · Cited by 852
. Survival of persons with and without HIV infection in Denmark, 1995-2005.
Lohse, N., Hansen, A.-B. E., Pedersen, G., Kronborg, G., Gerstoft, J., Sørensen, H. T., Væth, M., & Obel, N. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-2-200701160-00003 · Cited by 748
Flagged first, then by citations
Cited by
Sorted by citations
Items 701–702 of 702
Wang, Y., Sabit, A. H., Anzalone, J., Li, D., Hurwitz, E. G., Fadul, N. A., Wei, S., Olex, A. L., Safo, S. E., Islam, J. Y., et al. (2026) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofag560
Joe, J. R., Castro, C., Conner, S., Pitocchelli, H., Brown, M., Zeligman, M. R., Lombardi, D., Karran, A., & Gil, A. (2026) · Journal of Counseling & Development · doi:10.1002/jcad.70074
Metadata
- Authors
- Deeks, S. G., & Phillips, A. N.
- Affiliations
- San Francisco General Hospital (US)
- The Royal Free Hospital (GB)
- Corresponding author
- Deeks, S. G
- ORCID
- Phillips, A. N
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2009-01-26
- Volume
- 338
- Issue
- jan26 2
- Pages
- a3172-a3172
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- OpenAlex
- W2110559078
- Cited by
- 704
- References
- 25
- Citations by year
- 2026: 14 · 2025: 14 · 2024: 22 · 2023: 27 · 2022: 36 · 2021: 38 · 2020: 37 · 2019: 48 · 2018: 47 · 2017: 48 · 2016: 46 · 2015: 71 · 2014: 57 · 2013: 61 · 2012: 53
- FWCI
- 47.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- BMJ (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Keywords
- HIV infection, antiretroviral therapy, aging, CD4 count, cardiovascular disease, HIV-associated malignancies, kidney disease, drug resistance, long-term viral suppression
- MeSH terms
- Age Factors, Cardiovascular Diseases, Health Status, Humans, Kidney Diseases, Liver Diseases, Neoplasms, Risk Factors, HIV Infections, Treatment Outcome, CD4 Lymphocyte Count, Anti-HIV Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
