The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Antibiotic resistance in Enterobacteriaceae: mechanisms and clinical implications
Abstract
Resistance of the Enterobacteriaceae to antibiotics, especially of the β lactam type, is increasingly dominated by the mobilization of continuously expressed single genes that encode efficient drug modifying enzymes. Strong and ubiquitous selection pressure has seemingly been accompanied by a shift from "natural" resistance, such as inducible chromosomal enzymes, membrane impermeability, and drug efflux, to the modern paradigm of mobile gene pools that largely determine the epidemiology of modern antibiotic resistance. In this way, antibiotic resistance is more available than ever before to organisms such as Escherichia coli and Klebsiella pneumoniae that are important causes of major sepsis. Modulation of the phenotype by host bacteria makes gene transmission less obvious and may in part explain why tracking and control of carbapenem resistance has been particularly problematic in the Enterobacteriaceae. This review discusses the underlying principles and clinical implications of the mobility and fixation of resistance genes and the exploitable opportunities and potential threats arising from apparent limitations on diversity in these mobile gene pools. It also provides some illustrative paradoxes and clinical corollaries, as well as a summary of future options.
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Antibiotic resistance-the need for global solutions
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The shared antibiotic resistome of soil bacteria and human pathogens
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Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens
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Functional characterization of the antibiotic resistance reservoir in the human microflora
Sommer, M. O. A., Dantas, G., & Church, G. M. (2009) · Science · doi:10.1126/science.1176950 · Cited by 878
Antibiotic resistance is prevalent in an isolated cave microbiome
Bhullar, K., Waglechner, N., Pawlowski, A., Koteva, K., Banks, E. D., Johnston, M. D., Barton, H. A., & Wright, G. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034953 · Cited by 736
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“Blooming” in the gut: how dysbiosis might contribute to pathogen evolution.
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Cited by
Antibiotic resistance in microbes: History, mechanisms, therapeutic strategies and future prospects
Uddin, T. M., Chakraborty, A. J., Khusro, A., Zidan, B. R. M., Mitra, S., Emran, T. B., Dhama, K., Ripon, M. K. H., Gajdács, M., Sahibzada, M. U. K., et al. (2021) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2021.10.020 · Cited by 1,311
Environmental Factors Support the Formation of Specific Bacterial Assemblages on Microplastics
Oberbeckmann, S., Kreikemeyer, B., & Labrenz, M. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02709 · Cited by 549
Carbapenem-Resistant Acinetobacter baumannii and Enterobacteriaceae in South and Southeast Asia
Hsu, L.-Y., Apisarnthanarak, A., Khan, E., Suwantarat, N., Ghafur, A., & Tambyah, P. A. (2017) · Clinical Microbiology Reviews · doi:10.1128/cmr.00042-16 · Cited by 339
Escalating antimicrobial resistance among Enterobacteriaceae: Focus on carbapenemases
Lynch, J. P., Clark, N. M., & Zhanel, G. G. (2021) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2021.1904891 · Cited by 58
Mo, Y., Oonsivilai, M., Lim, C., Niehus, R., & Cooper, B. S. (2023) · PLOS Medicine · doi:10.1371/journal.pmed.1004013 · Cited by 52
Metadata
- Authors
- Iredell, J., Brown, J., & Tagg, K.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2016-02-08
- Volume
- 352
- Pages
- h6420
- ISSN
- 1756-1833 (ISSN-L)
- OpenAlex
- W2273170195
- Cited by
- 392
- References
- 8
- FWCI
- 12.48
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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