Bushehr Elderly Health (BEH) programme: study protocol and design of musculoskeletal system and cognitive function (stage II)
Open accessAbstract
Introduction: Musculoskeletal disorders and cognitive diseases are prevalent, and they are significant determinants of morbidity and mortality in older adults. The aim of this study is to investigate the prevalence of musculoskeletal and cognitive diseases and their risk factors and also to assess their associations during future follow-ups. Methods and analysis: Bushehr Elderly Health (BEH) programme is a population-based prospective cohort study being conducted in Bushehr, a southern province of Iran. A total of 3000 older people aged ≥60 years participated in the first stage from which 2772 were eligible to participate in the second stage, which started after 2.5 years. Data including demographic status, lifestyle factors, general healthandmedical history, and mentalandfunctional health are collected through a questionnaire. Anthropometric measures, performance testsandmuscle strength, blood pressure and and body composition measurements are done. A total 25 cc venous blood is taken, and sera are stored at –80°C for possible future analyses. Ethics and dissemination: The study protocol was approved by the ethics committee of Endocrinology and Metabolism Research Institute, affiliated to Tehran University of Medical Science as well as the Research Ethics Committee of Bushehr University of Medical Sciences. A written informed consent was signed by all the participants. The study findings will show the prevalence of musculoskeletal disease, cognitive impairment and their risk factors in an elderly population. The participants will be followed during the study to measure the occurrence outcomes. This study will also have the potential to inform the development of beneficial interventions to improve the management of musculoskeletal and cognitive impairment in Iran and other countries in the Middle East. Our findings will be disseminated via scientific publication as well as presentation to stakeholders, including the patients, clinicians, the public and policymakers, via appropriate avenues.
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Serum trigonelline is associated with muscle function in the independent Bushehr elderly health cohort.
“Analysis of the Bushehr elderly health cohort31 (Extended Data Table 2) demonstrated that serum trigonelline is also associated with muscle function in an independent replication study (Extended Data Fig. 1c).”
From Trigonelline Is an NAD+ Precursor That Improves Muscle Function during Ageing and Is Reduced in Human Sarcopenia (2024) · cites this paper as [31]
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“Analysis of the Bushehr elderly health cohort 31 (Extended Data Table 2) demonstrated that serum trigonelline is also associated with muscle function in an independent replication study (Extended Data Fig.”
BackgroundMethodInfluentialSelf-citation
- Authors
- Shafiee, G., Ostovar, A., Heshmat, R., Darabi, H., Sharifi, F., Raeisi, A., Mehrdad, N., Shadman, Z., Razi, F., Amini, M. R., Arzaghi, S. M., Meybodi, H. A., Soltani, A., Nabipour, I., & Larijani, B.
- Affiliations
- Endocrinology and Metabolism Population Sciences Institute (IR)
- Bushehr University of Medical Sciences (IR)
- Endocrinology and Metabolism Clinical Sciences Institute (IR)
- Corresponding author
- Nabipour, Iraj
- Larijani, Bagher
- ORCID
- Venue
- BMJ Open
- Publisher
- BMJ
- Published
- 2017-08
- Volume
- 7
- Issue
- 8
- Pages
- e013606
- ISSN
- 2044-6055 (ISSN-L)
- PMC
- PMC5577871
- OpenAlex
- W2745079190
- Cited by
- 94
- References
- 49
- Citations by year
- 2026: 13 · 2025: 16 · 2024: 17 · 2023: 12 · 2022: 8 · 2021: 16 · 2020: 6 · 2019: 6
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- BMJ Open (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Bushehr University of Medical Sciences Repository (Bushehr University of Medical Sciences) (acceptedVersion)
- Funders
- Bushehr University of Medical Sciences
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Keywords
- musculoskeletal disorders, cognitive impairment, older adults, prevalence, risk factors, population-based cohort, muscle strength, body composition, functional health, Middle East
- MeSH terms
- Aged, Aged, 80 and over, Female, Follow-Up Studies, Genetic Testing, Health Services for the Aged, Humans, Iran, Life Style, Male, Musculoskeletal Diseases, Patient Discharge, Physical Examination, Pilot Projects, Policy Making, Prospective Studies, Surveys and Questionnaires, Research Design, Risk Factors, Serologic Tests, Stroke, Quality Improvement, Cognitive Dysfunction
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