The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Coffee, including caffeinated and decaffeinated coffee, and the risk of hepatocellular carcinoma: A systematic review and dose-response meta-analysis
Abstract
Objectives: To examine the association between coffee, including caffeinated and decaffeinated coffee, with hepatocellular carcinoma (HCC) and assess the influence of HCC aetiology and pre-existing liver disease. Design: We performed a systematic review and meta-analysis. We calculated relative risks (RRs) of HCC according to caffeinated and decaffeinated coffee consumption using a random-effects dose–response meta-analysis. We tested for modification of the effect estimate by HCC aetiology and pre-existing liver disease. We judged the quality of evidence using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) criteria. Results: We found 18 cohorts, involving 2 272 642 participants and 2905 cases, and 8 case–control studies, involving 1825 cases and 4652 controls. An extra two cups per day of coffee was associated with a 35% reduction in the risk of HCC (RR 0.65, 95% CI 0.59 to 0.72). The inverse association was weaker for cohorts (RR 0.71, 95% CI 0.65 to 0.77), which were generally of higher quality than case–control studies (RR 0.53, 95% CI 0.41 to 0.69). There was evidence that the association was not significantly altered by stage of liver disease or the presence/absence of high alcohol consumption, high body mass index, type 2 diabetes mellitus, smoking, or hepatitis B and C viruses. An extra two cups of caffeinated and decaffeinated coffee (2 and 3 cohort studies, respectively) were associated with reductions of 27% (RR 0.73, 95% CI 0.63 to 0.85) and 14% (RR 0.86, 95% CI 0.74 to 1.00) in the risk of HCC. However, due to a lack of randomised controlled trials, potential publication bias and there being no accepted definition of coffee, the quality of evidence under the GRADE criteria was ‘very low’. Conclusions: Increased consumption of caffeinated coffee and, to a lesser extent, decaffeinated coffee are associated with reduced risk of HCC, including in pre-existing liver disease. These findings are important given the increasing incidence of HCC globally and its poor prognosis.
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“A meta-analysis of eighteen cohort and eight case-control studies reported an inverse association between coffee consumption and liver cancer with a risk ratio of 0.71 (95% CI = 0.65–0.77) for cohort studies and of 0.53 (95% CI = 0.41–0.69) for case-control studies, but the former are considered of higher quality than the latter.”
From Effects of Coffee on the Gastro-Intestinal Tract: A Narrative Review and Literature Update (2022) · cites this paper as [182]
In the citing paper
“A meta-analysis of eighteen cohort and eight case-control studies reported an inverse association between coffee consumption and liver cancer with a risk ratio of 0.71 (95% CI = 0.65–0.77) for cohort studies and of 0.53 (95% CI = 0.41–0.69) for case-control studies, but the former are considered of higher quality than the latter.”
From Effects of Coffee on the Gastro-Intestinal Tract: A Narrative Review and Literature Update (2022) · cites this paper as [182]
In the citing paper
“This association was not altered by the stage of the disease, the level of alcohol consumption, elevated body mass index, type 2 diabetes, or hepatitis B or C.”
From Effects of Coffee on the Gastro-Intestinal Tract: A Narrative Review and Literature Update (2022) · cites this paper as [182]
In the citing paper
“Both caffeinated and decaffeinated coffee are active [182].”
From Effects of Coffee on the Gastro-Intestinal Tract: A Narrative Review and Literature Update (2022) · cites this paper as [182]
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Citations
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Cited by
Llovet, J. M., Kelley, R. K., Villanueva, A., Singal, A. G., Pikarsky, E., Roayaie, S., Lencioni, R., Koike, K., Zucman-Rossi, J., & Finn, R. S. (2021) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-00240-3 · Cited by 7,055
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AASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma
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Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes
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Self-citation
Metadata
- Authors
- Kennedy, O. J., Roderick, P., Buchanan, R., Fallowfield, J. A., Hayes, P. C., & Parkes, J.
- Venue
- BMJ Open
- Publisher
- BMJ
- Published
- 2017-05
- Volume
- 7
- Issue
- 5
- Pages
- e013739
- ISSN
- 2044-6055
- Cited by
- 163
- References
- 9
- Language
- en
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