Placental antibody transfer: influence of maternal HIV infection and placental malaria
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AIM: To determine the influence of placental malaria, maternal HIV infection, and maternal hypergammaglobulinaemia on transplacental IgG antibody transfer. METHODS: One hundred and eighty materno-neonatal pairs from a Malawian population were assessed. Cord and maternal serum samples were tested for total serum IgG antibody titres using nephelometry, and for specific IgG antibody titres to Streptococcus pneumoniae, measles, and tetanus toxoid antibodies using an enzyme linked immunsorbent assay (ELISA). RESULTS: Multiple regression analyses showed that placental malaria was associated with a decrease in placental IgG antibody transfer to S pneumoniae and measles to 82% and 81%, respectively. Maternal HIV infection was associated with a reduction in IgG antibody transfer to S pneumoniae to 79%; raised maternal total serum IgG titres were correlated with S pneumoniae and measles IgG antibody transfer reduction to 86% and 87%, respectively. No effect was seen with tetanus toxoid antibody transfer. CONCLUSION: The combined influence of placental malaria, maternal HIV infection, and maternal hypergammaglobulinaemia seems to be linked to the low transplacental antibody transfer observed in the Malawian population.
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Calculations based on data from 9 African studies found that mothers averaged 17.3 ± 3.1 mg/ml IgG, cord blood 14.7 ± 2.5 mg/ml, with CMR of 0.85 ± 0.15.
“In comparison, calculations based on data from 9 African studies for mothers averaged 17.3 ± 3.1 mg/IgG, cord blood 14.7 ± 2.5 mg/ml, with CMR of 0.85 ± 0.15,13,14,16,30–34.”
From Transplacental transfer of total immunoglobulin G and antibodies to Plasmodium falciparum antigens between the 24th week of gestation and term (2022) · cites this paper as [31]
The Results (Table 2; page not available in our copy) report maternal and cord IgG measurements from this Malawian study, including 17.3 g/L for HIV-seronegative mothers. The paper does not report calculations across nine African studies or the quoted aggregate cord value, variability, and CMR, so it supports the underlying study-data citation but not those summary figures. (LLM, conf=0.86)
Experimental — accuracy not yet measuredOne Malawian study demonstrated that reduced antibody transfer in placental malaria may occur independently of hypergammaglobulinemia using multivariate regression analysis.
“One Malawian study demonstrated that reduced antibody transfer in placental malaria may occur independently of hypergammaglobulinemia using multivariate regression analysis (106);”
From Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy (2017) · cites this paper as [106]
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- Authors
- de Moraes-Pinto, M. I., Verhoeff, F., Chimsuku, L., Milligan, P. J. M., Wesumperuma, L., Broadhead, R. L., Brabin, B. J., Johnson, P. M., & Hart, C. A.
- Affiliations
- University of Liverpool (GB)
- Corresponding author
- Hart, C Anthony
- Venue
- Archives of Disease in Childhood - Fetal and Neonatal Edition
- Publisher
- BMJ
- Published
- 1998-11-01
- Volume
- 79
- Issue
- 3
- Pages
- F202-F205
- ISSN
- 1359-2998 (ISSN-L)
- 1468-2052
- PMC
- PMC1720856
- OpenAlex
- W2103326273
- Cited by
- 189
- References
- 0
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 8 · 2023: 9 · 2022: 9 · 2021: 8 · 2020: 10 · 2019: 15 · 2018: 9 · 2017: 14 · 2016: 16 · 2015: 6 · 2014: 8 · 2013: 9 · 2012: 6
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Archives of Disease in Childhood Fetal & Neonatal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Americanae (AECID Library) (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Funders
- Wellcome Trust
- European Commission
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- transplacental IgG transfer, placental malaria, maternal HIV, measles antibodies, tetanus toxoid antibodies, passive immunity, Malawi
- MeSH terms
- Adult, Antibodies, Bacterial, Antibodies, Viral, Female, Humans, Hypergammaglobulinemia, Immunoglobulin G, Immunity, Maternally-Acquired, Infant, Newborn, Malawi, Maternal-Fetal Exchange, Measles, Placenta, Pregnancy, Streptococcus pneumoniae, HIV Infections, Malaria, Falciparum
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