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Cited by 136Malaria Research and ControlGlobal Maternal and Child HealthMaternal and Neonatal Healthcare

Impact of Malaria at the End of Pregnancy on Infant Mortality and Morbidity

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Bardají, Azucena, Sigauque, Betuel, Sanz, Sergi, Maixenchs, María, Ordi, Jaume, Aponte, John J, Mabunda, Samuel, Alonso, Pedro L +1 more·2011·The Journal of Infectious Diseases
DOI 10.1093/infdis/jiq049PMC PMC3071276
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Abstract

BACKGROUND: There is some consensus that malaria in pregnancy may negatively affect infant's mortality and malaria morbidity, but there is less evidence concerning the factors involved. METHODS: A total of 1030 Mozambican pregnant women were enrolled in a randomized, placebo-controlled trial of intermittent preventive treatment with sulfadoxine-pyrimethamine, and their infants were followed up throughout infancy. Overall mortality and malaria morbidity rates were recorded. The association of maternal and fetal risk factors with infant mortality and malaria morbidity was assessed. RESULTS: There were 58 infant deaths among 997 live-born infants. The risk of dying during infancy was increased among infants born to women with acute placental infection (odds ratio [OR], 5.08 [95% confidence interval (CI), 1.77-14.53)], parasitemia in cord blood (OR, 19.31 [95% CI, 4.44-84.02]), low birth weight (OR, 2.82 [95% CI, 1.27-6.28]) or prematurity (OR, 3.19 [95% CI, 1.14-8.95]). Infants born to women who had clinical malaria during pregnancy (OR, 1.96 [95% CI, 1.13-3.41]) or acute placental infection (OR, 4.63 [95% CI, 2.10-10.24]) had an increased risk of clinical malaria during infancy. CONCLUSIONS: Malaria infection at the end of pregnancy and maternal clinical malaria negatively impact survival and malaria morbidity in infancy. Effective clinical management and prevention of malaria in pregnancy may improve infant's health and survival.

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  • Placenta malaria, especially active infection, has been linked to neonatal and infant mortality.

    “Placenta malaria, especially active infection, has been linked to neonatal and infant mortality.53”

    From Malaria in pregnancy. (2013) · cites this paper as [53]

    The Results section on multivariate analysis reports that placental malaria was associated with infant mortality, mainly among women with acute infection; it also reports an association with postneonatal mortality. The paper counts neonatal deaths but the passages found do not establish a separate association between placental malaria and neonatal mortality. (LLM, conf=0.82)

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  • Malaria infection during pregnancy increases the risk of infant's death and perinatal mortality by causing low birth weight.

    “It also increases the risk of infant’s death and perinatal mortality, by causing LBW.39,53,55”

    From Malaria in pregnancy. (2013) · cites this paper as [53]

    The Background passage (page unavailable) says malaria in pregnancy has been proposed to contribute to infant mortality through low birth weight, but calls the evidence on infant survival inconclusive. The Results associate acute placental infection and low birth weight with infant death; they do not establish that low birth weight mediates the infection’s effect. Perinatal death is mentioned only as a finding of a prior study, without a low-birth-weight mechanism. (LLM, conf=0.86)

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  • Congenital malaria can occur in the neonatal period and can contribute to infant morbidity and mortality.

    “Congenital malaria can occur in the neonatal period and can contribute to infant morbidity and mortality.53”

    From Malaria in pregnancy. (2013) · cites this paper as [53]

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Authors
Bardají, A., Sigauque, B., Sanz, S., Maixenchs, M., Ordi, J., Aponte, J. J., Mabunda, S., Alonso, P. L., & Menéndez, C.
Affiliations
  • Universitat de Barcelona (ES)
  • Manhiça Health Research Centre (MZ)
  • Ministry of Health (MZ)
Corresponding author
Bardají, Azucena
ORCID
Venue
The Journal of Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2011-01-03
Volume
203
Issue
5
Pages
691-699
ISSN
  • 0022-1899 (ISSN-L)
  • 1537-6613
DOI
10.1093/infdis/jiq049
PMC
PMC3071276
OpenAlex
W2168652259
Cited by
136
References
49
Citations by year
2026: 4 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 13 · 2019: 7 · 2018: 13 · 2017: 5 · 2016: 13 · 2015: 8 · 2014: 12 · 2013: 18 · 2012: 16
FWCI
16.36
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • The Journal of Infectious Diseases (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
Banco Bilbao Vizcaya Argentaria
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Global Maternal and Child Health
  • Health Sciences › Health Professions › General Health Professions › Maternal and Neonatal Healthcare
Keywords
malaria in pregnancy, infant mortality, infant morbidity, clinical malaria, placental malaria, low birth weight, preterm birth, sulfadoxine-pyrimethamine, intermittent preventive treatment, maternal risk factors, Mozambique
MeSH terms
Antimalarials, Drug Combinations, Female, Humans, Infant Mortality, Infant, Newborn, Morbidity, Mozambique, Placebos, Placenta, Pregnancy, Pregnancy Outcome, Pyrimethamine, Surveys and Questionnaires, Risk Factors, Sulfadoxine, Pregnancy Complications, Parasitic, Proportional Hazards Models, Malaria, Falciparum

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