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Cited by 122Malaria Research and ControlNeonatal and Maternal InfectionsReproductive System and Pregnancy

The influence of placental malaria infection and maternal hypergammaglobulinemia on transplacental transfer of antibodies and IgG subclasses in a rural West African population

Okoko, Brown J., Wesumperuma, Lalanga H., Ota, Martin O. C., Pinder, Margaret, Banya, Winston, Gomez, Silver F., McAdam, Keith P. J., Hart, Anthony C.·2001·The Journal of Infectious Diseases
DOI 10.1086/322808
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Abstract

Two hundred thirteen mother-baby pairs in The Gambia were studied to determine the influence of placental malaria infection and maternal hypergammaglobulinemia on transplacental antibody transfer. Antibody transfer for herpes simplex virus 1 (HSV-1), respiratory syncytial virus (RSV), and varicella-zoster virus (VZV) was significantly reduced by placental malaria infection by 69%, 58%, and 55%, respectively. Maternal hypergammaglobulinemia was associated with a significant reduction in antibody transfer for HSV-1, RSV, VZV, and pneumococcus by 89%, 90%, 91%, and 88%, respectively. In addition, placental malaria infection was associated with a significant reduction in transfer of IgG1, IgG2, and IgG4 (P<.01, P=.01, and P=.03, respectively) but not of IgG3 (P=.59). Maternal hypergammaglobulinemia significantly impaired the transfer of IgG1 and IgG2 (P=.01) but not of IgG3 or IgG4 (P=.62 and P=.59, respectively). Placental malaria infection and maternal hypergammaglobulinemia were associated with reduction in the transplacental transfer of these specific antibodies, IgG1, and IgG2 in this Gambian population.

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  • More recent studies demonstrate negative correlations between maternal IgG levels and placental transfer ratios for both total and antigen-specific IgG.

    “Furthermore, a number of more recent studies have demonstrated negative correlations between maternal IgG levels and placental transfer ratios for both total and antigen-specific IgG (96–98).”

    From Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy (2017) · cites this paper as [96]

    The Placental Antibody Transfer section (page unavailable) reports reduced transfer of IgG specific to HSV-1, RSV, VZV, and S. pneumoniae in mothers with high total IgG, supporting the antigen-specific part of the claim. It reports lower transfer of IgG1 and IgG2, but not a negative correlation between maternal IgG levels and a total-IgG transfer ratio. (LLM, conf=0.85)

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  • HIgG and/or placental malaria reduce transfer of IgG to some pathogens including herpes simplex, respiratory syncytial, and varicella-zoster, but not to diphtheria toxoid, S. pneumonia, Hemophilis influenza type b, and tetanus toxoid.

    “Okoko and colleagues (2001) reported that both HIgG and/or PM reduced the transfer of IgG to some pathogens including herpes simplex, respiratory syncytial, varicella-zoster, but not to diphtheria toxoid, S. pneumonia, Hemophilis influenza type b, and TTx21.”

    From Transplacental transfer of total immunoglobulin G and antibodies to Plasmodium falciparum antigens between the 24th week of gestation and term (2022) · cites this paper as [21]

    The Placental Antibody Transfer section reports reduced transfer of HSV-1, RSV, and VZV antibodies with both placental malaria and maternal hypergammaglobulinemia. It reports no significant effect on diphtheria toxoid or Hib transfer, but hypergammaglobulinemia did reduce S. pneumoniae antibody transfer. Tetanus toxoid was not among the antibodies tested in this study; the Discussion describes findings from other studies instead. Page numbers were not provided in our copy. (LLM, conf=0.91)

    Experimental — accuracy not yet measured

  • Maternal antibody levels play a role in determining transfer efficiency.

    “It is well established that maternal antibody levels play a role in determining transfer efficiency.”

    From Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy (2017) · cites this paper as [96]

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Cites

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Research works printed but not linked: 5

  1. [6]6. Saji F, Koyama M, Matsuzaki N. Current topic: human placental Fc recep- tors. Placenta 1994; 15:453-66.
  2. [11]11. de Moraes-Pinto MI, Almeida ACM, Kenj G, et al. Placental transfer and maternally acquired neonatal IgG immunity in HIV infection. J Infect Dis 1996; 173:1077-84.
  3. [21]21. Whittle H, Aaby P, Samb B, et al. Poor serologic responses five to seven years after immunization with high and standard titre measles vaccines. Pediatr Infect Dis J 1999; 18:53-7.
  4. [24]24. Gendrel D, Richard-Lenoble D, Blot P, Fribourg-Blanc A. Transfert des immunoglobulines et des anti-corps antirougeoleux de la mere a' l'enfant en Afrique et en Europe. Presse Med 1998; 17:1633-6.
  5. [27]27. Leach JL, Sedmark DD, Osborn JM, Rahill B, Lairmore MD, Anderson CL. Isolation from human placenta of the IgG, FcRn and localization to the syncytiotrophoblast. J Immunol 1996; 157:3317-22.

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Authors
Okoko, B. J., Wesumperuma, L. H., Ota, M. O. C., Pinder, M., Banya, W., Gomez, S. F., McAdam, K. P. J., & Hart, A. C.
Affiliations
  • Medical Research Council (GB)
  • University of Liverpool (GB)
  • Edward Francis Small Teaching Hospital (GM)
Corresponding author
Okoko, Brown J.
ORCID
Venue
The Journal of Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2001-09
Volume
184
Issue
5
Pages
627-632
ISSN
  • 0022-1899 (ISSN-L)
  • 1537-6613
DOI
10.1086/322808
OpenAlex
W1979281299
Cited by
121
References
27
Citations by year
2026: 5 · 2025: 3 · 2024: 10 · 2023: 4 · 2022: 8 · 2021: 6 · 2020: 10 · 2019: 8 · 2018: 9 · 2017: 12 · 2016: 7 · 2015: 6 · 2014: 5 · 2013: 1 · 2012: 3
FWCI
3.49
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Keywords
placental malaria, transplacental antibody transfer, IgG subclasses, IgG1, IgG2, IgG3, IgG4, herpes simplex virus type 1, respiratory syncytial virus, varicella-zoster virus, Streptococcus pneumoniae, Gambia
MeSH terms
Adult, Animals, Antibodies, Bacterial, Antibodies, Viral, Female, Gambia, Humans, Hypergammaglobulinemia, Immunoglobulin G, Immunity, Maternally-Acquired, Infant, Newborn, Male, Placenta, Placenta Diseases, Plasmodium falciparum, Pregnancy, Pregnancy Complications, Parasitic, Malaria, Falciparum

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