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Alteration of the spinal modulation of nociceptive processing in patients with irritable bowel syndrome

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Coffin, B, Bouhassira, D, Sabaté, J-M, Barbe, L, Jian, R·2004·Gut

DOI 10.1136/gut.2003.031310PMC PMC1774236

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Abstract

BACKGROUND: Visceral hypersensitivity has been evidenced in patients with irritable bowel syndrome (IBS) but its mechanisms remain poorly elucidated. We investigated the spinal transmission of nociceptive signals in IBS patients by analysing the effects of rectal distensions on electromyographic recordings of the somatic nociceptive flexion (RIII) reflex, an objective index of spinal nociceptive processes. METHODS: Fourteen IBS and 10 healthy volunteers were included in the study. Slow ramp (40 ml/min) and rapid phasic (900 ml/min, 10, 20, 30, and 40 mm Hg) rectal distensions were randomly performed while the RIII reflex evoked by electrical stimulation of the sural nerve at the ankle was continuously recorded from the ipsilateral biceps femoris. RESULTS: In healthy volunteers, significant progressive inhibition of the RIII reflex was observed during slow ramp distension (61 (13)% of control values) while biphasic effects (facilitation and inhibition) were observed during rapid distensions. In contrast, in IBS patients, the RIII reflex was significantly facilitated during slow ramp distension (139 (15)% of control values) and inhibitions induced by rapid distensions were significantly reduced. Volumes of distension and rectal compliance were similar in both groups. CONCLUSIONS: Our results provide direct evidence that a hyperexcitability of spinal nociceptive processes is present in a large subgroup of IBS patients.

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Authors: Coffin, B., Bouhassira, D., Sabaté, J.-M., Barbe, L., & Jian, R.
Affiliations: Hôpital Louis-Mourier (FR)
Inserm (FR)
Assistance Publique – Hôpitaux de Paris (FR)
Corresponding author: Coffin, B
ORCID: Coffin, B
Sabaté, J-M
Venue: Gut
Publisher: BMJ
Published: 2004-09-10
Volume: 53
Issue: 10
Pages: 1465-1470
ISSN: 0017-5749 (ISSN-L)
1468-3288
DOI: 10.1136/gut.2003.031310
PMC: PMC1774236
OpenAlex: W2076464902
Cited by: 117
References: 30
Citations by year: 2026: 1 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 6 · 2012: 11
FWCI: 6.97
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Gut (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
Keywords: irritable bowel syndrome, visceral hypersensitivity, spinal nociceptive processing, rectal distension, RIII reflex, sural nerve stimulation, rectal compliance
MeSH terms: Adult, Aged, Dilatation, Electric Stimulation, Electromyography, Female, Humans, Male, Middle Aged, Nociceptors, Pain Measurement, Rectum, Reflex, Sensation, Spinal Cord, Sural Nerve, Irritable Bowel Syndrome

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Alteration of the spinal modulation of nociceptive processing in patients with irritable bowel syndrome

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