Stress-related changes in oesophageal permeability: filling the gaps of GORD?: Figure 1
Open accessAbstract
Albeit remaining a controversial issue, it has become increasingly recognised that psychological stress has a major impact on gut mucosal function and affects the course of gastrointestinal disorders. Research during the last decade has shown that stress causes barrier dysfunction of the gastrointestinal mucosa by mechanisms that mainly involve neuropeptides and mast cells. Moreover, accumulating evidence implicates increased permeability as a pathogenic factor in gastroesophageal reflux disease (GORD). Recent data demonstrating that psychological stress may induce a permeability defect in stratified epithelia, including the oesophagus, shed new light on the pathophysiological events leading to heartburn and GORD.
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Several animal and human studies suggest that postprandial hyperglycemia is responsible for initiating esophageal mucosal injury and the development of dysmotility.
“Several animal and human studies suggest that this is responsible for initiating esophageal mucosal injury and the development of dysmotility [13], [18], [19].”
From Cytoprotective Effects of Hydrogen Sulfide in Novel Rat Models of Non-Erosive Esophagitis (2014) · cites this paper as [18]
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Gastroesophageal reflux disease–from reflux episodes to mucosal inflammation
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“esophageal mucosal injury and the development of dysmotility [13,18,19].”
Background
- Authors
- Söderholm, J. D.
- Affiliations
- Linköping University (SE)
- Corresponding author
- Söderholm, Johan D
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2007-04-20
- Volume
- 56
- Issue
- 9
- Pages
- 1177.1-1180
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1954954
- OpenAlex
- W2051879837
- Cited by
- 25
- References
- 64
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 1
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Gut (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Vetenskapsrådet
- Svenska Läkaresällskapet
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Keywords
- psychological stress, gastroesophageal reflux disease, neuropeptides, mast cells, heartburn, stratified epithelium
- MeSH terms
- Corticotropin-Releasing Hormone, Epithelium, Esophagus, Gastroesophageal Reflux, Humans, Mast Cells, Models, Biological, Permeability, Stress, Psychological
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