Cited by 25Gastroesophageal reflux and treatmentsGastrointestinal motility and disordersHelicobacter pylori-related gastroenterology studies

Stress-related changes in oesophageal permeability: filling the gaps of GORD?: Figure 1

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Söderholm, Johan D·2007·Gut

Abstract

Albeit remaining a controversial issue, it has become increasingly recognised that psychological stress has a major impact on gut mucosal function and affects the course of gastrointestinal disorders. Research during the last decade has shown that stress causes barrier dysfunction of the gastrointestinal mucosa by mechanisms that mainly involve neuropeptides and mast cells. Moreover, accumulating evidence implicates increased permeability as a pathogenic factor in gastroesophageal reflux disease (GORD). Recent data demonstrating that psychological stress may induce a permeability defect in stratified epithelia, including the oesophagus, shed new light on the pathophysiological events leading to heartburn and GORD.

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Crossref · 10.1136/gut.2007.120691

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64 of 64 references verified0 citation errors · 0 not checkable

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  • Several animal and human studies suggest that postprandial hyperglycemia is responsible for initiating esophageal mucosal injury and the development of dysmotility.

    “Several animal and human studies suggest that this is responsible for initiating esophageal mucosal injury and the development of dysmotility [13], [18], [19].”

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Authors
Söderholm, J. D.
Affiliations
Linköping University (SE)
Corresponding author
Söderholm, Johan D
Venue
Gut
Publisher
BMJ
Published
2007-04-20
Volume
56
Issue
9
Pages
1177.1-1180
ISSN
  • 0017-5749 (ISSN-L)
  • 1468-3288
OpenAlex
W2051879837
Cited by
25
References
64
Citations by year
2026: 2 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 1
FWCI
2.11
Type
journal article
Language
en
Open access
Locations
  • Gut (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Funders
  • Vetenskapsrådet
  • Svenska Läkaresällskapet
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
Keywords
psychological stress, gastroesophageal reflux disease, neuropeptides, mast cells, heartburn, stratified epithelium
MeSH terms
Corticotropin-Releasing Hormone, Epithelium, Esophagus, Gastroesophageal Reflux, Humans, Mast Cells, Models, Biological, Permeability, Stress, Psychological

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