Level of chronic life stress predicts clinical outcome in irritable bowel syndrome
Open accessAbstract
Background—Life stress contributes to symptom onset and exacerbation in the majority of patients with irritable bowel syndrome (IBS) and functional dyspepsia (FD); research evidence is conflicting, however, as to the strength of these effects. Aims—To test prospectively the relation of chronic life stress threat to subsequent symptom intensity over time. Patients—One hundred and seventeen consecutive outpatients satisfying the modified Rome criteria for IBS (66% with one or more concurrent FD syndromes) participated. Methods—The life stress and symptom intensity measures were determined from interview data collected independently at entry, and at six and 16 months; these measures assessed the potency of chronic life stress threat during the prior six months or more, and the severity and frequency of IBS and FD symptoms during the following two weeks. Results—Chronic life stress threat was a powerful predictor of subsequent symptom intensity, explaining 97% of the variance on this measure over 16 months. No patient exposed to even one chronic highly threatening stressor improved clinically (by 50%) over the 16 months; all patients who improved did so in the absence of such a stressor. Conclusion—The level of chronic life stress threat predicts the clinical outcome in most patients with IBS/FD.
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Early life experiences, adult stressors, lack of social support, and other social learning experiences can affect physiological and psychological responses and may precipitate abdominal distress and psychiatric disorders.
“Early life experiences (e.g., abuse), adult stressors (e.g., divorce or bereavement), lack of social support, and other social learning experiences can affect both an individual’s physiological and psychological responses, and may precipitate abdominal distress, as well as psychiatric disorders (4,7–11).”
From Psychosocial Distress and Somatic Symptoms in Community Subjects With Irritable Bowel Syndrome: A Psychological Component Is the Rule (2009) · cites this paper as [11]
Increased intestinal permeability is a critical event in the onset of clinical symptoms of GI disorders including IBS and IBD.
“a critical event in the onset of clinical symptoms of GI disorders including irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) [7], [8], [9], [10]”
From CRF induces intestinal epithelial barrier injury via the release of mast cell proteases and TNF-α (2012) · cites this paper as [8]
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Cites
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267 · see citing works
(1970) · Cited by 24,983 · see citing works
Social Origins of Depression: A Study of Psychiatric Disorder in Women.
Schnitzer, P. K., Brown, G. W., & Harris, T. (1980) · Contemporary Sociology A Journal of Reviews · doi:10.2307/2065631 · Cited by 3,053 · see citing works
Social Origins of Depression: A Study of Psychiatric Disorder in Women
McDaniel, E. G. (1980) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-198009000-00013 · Cited by 1,894 · see citing works
Assessment of Anger: The State-Trait Anger Scale
Butcher, J. N., Spielberger, C. D., & Spielberger, C. D. (2013) · Medical Entomology and Zoology · doi:10.4324/9781315825656-12 · Cited by 1,245 · see citing works
Psychosocial Factors in the Irritable Bowel Syndrome
Drossman, D. A., McKee, D. C., Sandler, R. S., Mitchell, C. M., Cramer, E. M., Lowman, B. C., & Burger, A. L. (1988) · Gastroenterology · doi:10.1016/s0016-5085(88)80017-9 · Cited by 757 · see citing works
Agréus, L., Svärdsudd, K., Nyrén, O., & Tibblin, G. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90373-9 · Cited by 686 · see citing works
Chaudhary, N. A., & Truelove, S. C. (1962) · QJM · doi:10.1093/oxfordjournals.qjmed.a066971 · Cited by 498 · see citing works
Onset and Disappearance of Gastrointestinal Symptoms and Functional Gastrointestinal Disorders
Talley, N. J., Weaver, A. L., Zinsmeister, A. R., & Melton, L. J. (1992) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116483 · Cited by 471 · see citing works
A controlled trial of psychological treatment for the irritable bowel syndrome
Guthrie, E., Creed, F. H., Dawson, D., & Tomenson, B. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90215-7 · Cited by 461 · see citing works
Whitehead, W. E., Crowell, M. D., Robinson, J. C., Heller, B. R., & Schuster, M. M. (1992) · Gut · doi:10.1136/gut.33.6.825 · Cited by 432 · see citing works
PROGNOSIS IN THE IRRITABLE BOWEL SYNDROME: A 5-YEAR PROSPECTIVE STUDY
Harvey, R. F., Mauad, E. C., & Brown, A. M. (1987) · The Lancet · doi:10.1016/s0140-6736(87)90304-7 · Cited by 212 · see citing works
Psychosocial aspects of the functional gastrointestinal disorders
Drossman, D. A. (1996) · De Gruyter eBooks · doi:10.1515/9783110815542-005 · Cited by 194 · see citing works
Goal frustration and life events in the aetiology of painful gastrointestinal disorder
Craig, T., & Brown, G. W. (1984) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(84)90073-4 · Cited by 177 · see citing works
PSYCHOSOCIAL ASPECTS OF FUNCTIONAL GASTROINTESTINAL DISORDERS
Whitehead, W. E. (1996) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(05)70363-0 · Cited by 158 · see citing works
The functional gastrointestinal disorders: Diagnosis, pathophysiology, and treatment
Camilleri, M. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90612-6 · Cited by 157 · see citing works
Functional gastrointestinal disorders: psychological, social, and somatic features
Bennett, E. J., Piesse, C., Palmer, K. R., Badcock, C.-A., Tennant, C. C., & Kellow, J. E. (1998) · Gut · doi:10.1136/gut.42.3.414 · Cited by 147 · see citing works
Self-citationPROGNOSIS IN THE IRRITABLE-BOWEL SYNDROME
Waller, S., & Misiewicz, J. J. (1969) · The Lancet · doi:10.1016/s0140-6736(69)90475-9 · Cited by 135 · see citing works
Stress Management for Irritable Bowel Syndrome: A Controlled Trial
Shaw, G., Srivastava, E. D., Sadlier, M., Swann, P., James, J., & Rhodes, J. (2009) · Digestion · doi:10.1159/000200738 · Cited by 125 · see citing works
The contextual threat of life events: the concept and its reliability
Tennant, C., Smith, A., Bebbington, P., & Hurry, J. (1979) · Psychological Medicine · doi:10.1017/s0033291700032086 · Cited by 96 · see citing works
Self-citationLife stress and non-ulcer dyspepsia: A case-control study
Bennett, E., Beaurepaire, J., Langeluddecke, P., Kellow, J. E., & Tennant, C. (1991) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(91)90052-p · Cited by 81 · see citing works
Self-citationMajor life event stress and dyspepsia of unknown cause: a case control study.
Talley, N. J., & Piper, D. W. (1986) · Gut · doi:10.1136/gut.27.2.127 · Cited by 79 · see citing works
Haug, T. T., Wilhelmsen, I., Berstad, A., & Ursin, H. (1995) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529509089784 · Cited by 70 · see citing works
Suls, J. M., Wan, C. K., & Blanchard, E. B. (1994) · Health Psychology · doi:10.1037/0278-6133.13.2.103 · Cited by 69 · see citing works
The perception of life events and daily stress in nonulcer dyspepsia.
Hui, W. M., Shiu, L. P., & Lam, S. (1991) · PubMed · Cited by 65 · see citing works
Latent trait analysis of the eysenck personality questionnaire
Grayson, D. A. (1986) · Journal of Psychiatric Research · doi:10.1016/0022-3956(86)90005-1 · Cited by 64 · see citing works
Talley, N. J., & Piper, D. W. (1987) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528709078590 · Cited by 46 · see citing works
Dinan, T. G., O’Keane, V., O’Boyle, C. A., Chua, A., & Keeling, P. W. N. (1991) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1991.tb01416.x · Cited by 38 · see citing works
Assessing the effects of stress on physical symptoms.
Whitehead, W. E. (1994) · Health Psychology · doi:10.1037//0278-6133.13.2.99 · Cited by 32 · see citing works
Invited review: The irritable bowel syndrome
Ford, M. J. (1986) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(86)90079-6 · Cited by 31 · see citing works
BINUCLEATE HUMAN OOCYTES FROM LARGE FOLLICLES
Kennedy, J., & DONAHUE, R. P. (1969) · The Lancet · doi:10.1016/s0140-6736(69)91755-3 · Cited by 31 · see citing works
The relationship between hassles, uplifts and irritable bowel syndrome: A preliminary study
Dancey, C. P., Whitehouse, A., Painter, J., & Backhouse, S. (1995) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(95)00016-x · Cited by 24 · see citing works
Chaos theory, sensitive dependence, and the logistic equation.
Mandel, D. R. (1995) · American Psychologist · doi:10.1037/0003-066x.50.2.106 · Cited by 22 · see citing works
Psychosocial Factors in Gastrointestinal Illness
Cassileth, B. R., & Drossman, D. A. (2010) · Psychotherapy and Psychosomatics · doi:10.1159/000288657 · Cited by 17 · see citing works
Robertson, C. A. (2010) · Oxford University Press eBooks · doi:10.1093/med/9780195378818.003.0026 · Cited by 14 · see citing works
Chaos theory, sensitive dependence, and the logistic equation.
Mandel, D. R. (1995) · American Psychologist · doi:10.1037//0003-066x.50.2.106 · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Ford MJ. The irritable bowel syndrome. J Psychosom Res 1986;30:399-410.
- Bennett, Tennant, Piesse, et al on July 20, 2023 by guest. Protected by copyright. http://gut.bmj.com/ Gut: first published as 10.1136/gut.43.2.256 on 1 August 1998. Downloaded from
Cited by
Sorted by citations
Intestinal barrier function: molecular regulation and disease pathogenesis
Groschwitz, K. R., & Hogan, S. P. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.05.038 · Cited by 1,775 · see citing works
AGA technical review on irritable bowel syndrome.
Drossman, D. A., Camilleri, M., Mayer, E. A., & Whitehead, W. E. (2002) · Gastroenterology · doi:10.1053/gast.2002.37095 · Cited by 1,384 · see citing works
Messaoudi, M., Lalonde, R., Violle, N., Javelot, H., Desor, D., Nejdi, A., Bisson, J.-F., Rougeot, C., Pichelin, M., Cazaubiel, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114510004319 · Cited by 1,324 · see citing works
“Indeed, several studies have indicated that stressful events are associated with the onset of chronic GI disturbances (5) , functional ones (6–8) , inflammatory bowel disease (9–12) or peptic ulcers (13–16) , as well as anxiety and depression depending on the genetic background (17–19) .”
Enck, P., Aziz, Q., Barbara, G., Farmer, A. D., Fukudo, S., Mayer, E. A., Niesler, B., Quigley, E. M. M., Rajilić-Stojanović, M. D., Schemann, M., et al. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.14 · Cited by 1,057 · see citing works
Postinfectious Irritable Bowel Syndrome
Spiller, R., & Garsed, K. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.074 · Cited by 1,024 · see citing works
Guidelines on the irritable bowel syndrome: mechanisms and practical management
Spiller, R., Aziz, Q., Creed, F., Emmanuel, A., Houghton, L., Hungin, P., Jones, R., Kumar, D., Rubin, G., Trudgill, N., et al. (2007) · Gut · doi:10.1136/gut.2007.119446 · Cited by 818 · see citing works
Psychosocial Aspects of the Functional Gastrointestinal Disorders
Levy, R. L., Olden, K. W., Naliboff, B. D., Bradley, L. A., Francisconi, C., Drossman, D. A., & Creed, F. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.057 · Cited by 776 · see citing works
Shippee, N. D., Shah, N. D., May, C. R., Mair, F. S., & Montori, V. M. (2012) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2012.05.005 · Cited by 728 · see citing works
Anxiety disorders and comorbid medical illness
Roy-Byrne, P. P., Davidson, K. W., Kessler, R. C., Asmundson, G. J. G., Goodwin, R. D., Kubzansky, L., Lydiard, R. B., Massie, M. J., Katon, W., Laden, S. K., et al. (2008) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2007.12.006 · Cited by 668 · see citing works
“[44] Bennett EJ, Tennant CC, Piesse C, Badcock CA, Kellow JE.”
BackgroundThe neurobiology of stress and gastrointestinal disease
MAYER, E. A. (2000) · Gut · doi:10.1136/gut.47.6.861 · Cited by 666 · see citing works
Vanuytsel, T., van Wanrooy, S., Vanheel, H., Vanormelingen, C., Verschueren, S., Houben, E., Salim Rasoel, S., Tόth, J., Holvoet, L., Farré, R., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-305690 · Cited by 615 · see citing works
(2011) · Springer eBooks · doi:10.1007/springerreference_44317 · Cited by 549 · see citing works
Van Oudenhove, L., Levy, R. L., Crowell, M. D., Drossman, D. A., Halpert, A. D., Keefer, L., Lackner, J. M., Murphy, T. B., & Naliboff, B. D. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.027 · Cited by 512 · see citing works
Early weaning stress impairs development of mucosal barrier function in the porcine intestine
Smith, F., Clark, J. E., Overman, B. L., Tozel, C. C., Huang, J. H., Rivier, J., Blikslager, A. T., & Moeser, A. J. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00081.2009 · Cited by 502 · see citing works
Labus, J. S., Bolus, R., Chang, L., Wiklund, I., Naesdal, J., Mayer, E. A., & Naliboff, B. D. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02007.x · Cited by 475 · see citing works
II. Stress and intestinal barrier function
Söderholm, J. D., & Perdue, M. H. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.1.g7 · Cited by 467 · see citing works
Tibble, J. A., Sigthorsson, G., Foster, F., Forgács, I., & Bjarnason, I. (2002) · Gastroenterology · doi:10.1053/gast.2002.34755 · Cited by 437 · see citing works
Galley, J. D., Nelson, M. C., Yu, Z., Dowd, S. E., Walter, J., Kumar, P., Lyte, M., & Bailey, M. T. (2014) · BMC Microbiology · doi:10.1186/1471-2180-14-189 · Cited by 398 · see citing works
Stress and the Microbiota–Gut–Brain Axis in Visceral Pain: Relevance to Irritable Bowel Syndrome
Moloney, R. D., Johnson, A. C., O’Mahony, S. M., Dinan, T. G., Meerveld, B. G., & Cryan, J. F. (2015) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12490 · Cited by 396 · see citing works
Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum
Guilarte, M., Santos, J., de Torres, I., Alonso, C., Vicario, M., Ramos, L., Martinez, C., Casellas, F., Saperas, E., & Malagelada, J. R. (2007) · Gut · doi:10.1136/gut.2006.100594 · Cited by 385 · see citing works
Chang, L., Toner, B. B., Fukudo, S., Guthrie, E., Locke, G. R., Norton, N. J., & Sperber, A. D. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.09.071 · Cited by 374 · see citing works
Spiller, R. E. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00324-x · Cited by 353 · see citing works
Taché, Y., Martı́nez, V., Million, M., & Wang, L. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.2.g173 · Cited by 347 · see citing works
“This preliminary report of beneficial effects of CRF-R1 antagonist treatment on depressive symptoms in patients with major depression (34) suggests a therapeutic potential for CRF-R1 antagonists, particularly in subsets of IBS patients who have psychiatric illness and GI symptoms of enhanced bowel motor function.”
BackgroundInfluentialEvolving pathophysiologic models of functional gastrointestinal disorders
Mayer, E. A., & Collins, S. M. (2002) · Gastroenterology · doi:10.1053/gast.2002.33584 · Cited by 326 · see citing works
Pain and inflammatory bowel disease.
Bielefeldt, K., Davis, B., & Binion, D. G. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20848 · Cited by 304 · see citing works
Irritable bowel syndrome: a little understood organic bowel disease?
Talley, N. J., & Spiller, R. E. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09712-x · Cited by 304 · see citing works
Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia
Bradesi, S., Schwetz, I., Ennes, H. S., Lamy, C. M., Ohning, G., Fanselow, M. S., Pothoulakis, C., McRoberts, J. A., & Mayer, E. A. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00500.2004 · Cited by 307 · see citing works
“The increased mast cell numbers found in the current study are in accordance with numerous reports showing stress-induced mast cell activation at the gut level (13, 48, 19) and with increased mast cell numbers in colonic biopsies from some IBS patients (3).”
BackgroundResultInfluentialRichard Locke, G., Weaver, A. L., Joseph Melton, L., & Talley, N. J. (2004) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.04043.x · Cited by 278 · see citing works
Xu, D., Gao, J., Gillilland, M., Wu, X., Song, I., Kao, J. Y., & Owyang, C. (2014) · Gastroenterology · doi:10.1053/j.gastro.2013.10.026 · Cited by 271 · see citing works
Prognosis in post-infective irritable bowel syndrome: a six year follow up study
Neal, K. R., Barker, L., & Spiller, R. E. (2002) · Gut · doi:10.1136/gut.51.3.410 · Cited by 274 · see citing works
The Role of Stress on Physiologic Responses and Clinical Symptoms in Irritable Bowel Syndrome
Chang, L. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.01.032 · Cited by 268 · see citing works
Lee, C., Doo, E.-Y., Choi, J. M., Jang, S.-H., Ryu, H.-S., Lee, J. Y., Oh, J. H., Park, J. H., & Kim, Y. S. (2017) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm16220 · Cited by 260 · see citing works
Corticotropin-releasing hormone mimics stress-induced colonic epithelial pathophysiology in the rat
Santos, J., Saunders, P. R., Hanssen, N. P. M., Yang, P., Yates, D. A., Groot, J. A., & Perdue, M. H. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.277.2.g391 · Cited by 251 · see citing works
Health-Related Quality of Life and Health Care Costs in Severe, Refractory Irritable Bowel Syndrome
Creed, F. H., Ratcliffe, J., Fernandez, L., Tomenson, B., Palmer, S., Rigby, C., Guthrie, E., Read, N., & Thompson, D. G. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-9_part_2-200105011-00010 · Cited by 246 · see citing works
Mearin, X. B. (2001) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520152584770 · Cited by 240 · see citing works
Layer, P., Andresen, V., Pehl, C., Allescher, H. ‐., Bischoff, S., Claßen, M., Enck, P., Frieling, T., Haag, S., Holtmann, G., et al. (2011) · Zeitschrift für Gastroenterologie · doi:10.1055/s-0029-1245976 · Cited by 231 · see citing works
Taché, Y., Martı́nez, V., Wang, L., & Million, M. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705760 · Cited by 228 · see citing works
Potential Mechanisms Underlying Centralized Pain and Emerging Therapeutic Interventions
Eller-Smith, O. C., Nicol, A. L., & Christianson, J. A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00035 · Cited by 227 · see citing works
Martínez-Martínez, L.-A., Mora, T., Vargas, A., Fuentes-Iniestra, M., & Martínez-Lavín, M. (2014) · JCR: Journal of Clinical Rheumatology · doi:10.1097/rhu.0000000000000089 · Cited by 224 · see citing works
Martínez, C., Vicario, M., Ramos, L., Lobo, B., Mosquera, J. L., Alonso, C., Sánchez, A., Guilarte, M., Antolín, M., de Torres, I., et al. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.472 · Cited by 214 · see citing works
Visceral hyperalgesia in children with functional abdominal pain
Lorenzo, C. D., Youssef, N. N., Sigurðsson, L., Scharff, L., Griffiths, J., & Wald, A. M. (2001) · The Journal of Pediatrics · doi:10.1067/mpd.2001.118883 · Cited by 223 · see citing works
Meta‐analysis: the treatment of irritable bowel syndrome
Pantoflickova, D., Michetti, P., Fried, M., Beglinger, C., & Blum, A. L. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02267.x · Cited by 222 · see citing works
New pathophysiological mechanisms in irritable bowel syndrome
Barbara, G., GIORGIO, R. D., Stanghellini, V., Cremon, C., Salvioli, B., & Corinaldesi, R. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02036.x · Cited by 221 · see citing works
Gender-related differences in irritable bowel syndrome: Potential mechanisms of sex hormones
Méleine, M. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i22.6725 · Cited by 220 · see citing works
Stress and visceral pain: From animal models to clinical therapies
Larauche, M. H., Mulak, A., & Taché, Y. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.04.020 · Cited by 212 · see citing works
Mertz, H. R. (2003) · New England Journal of Medicine · doi:10.1056/nejmra035579 · Cited by 206 · see citing works
CRF induces intestinal epithelial barrier injury via the release of mast cell proteases and TNF-α
Overman, E. L., Rivier, J. E., & Moeser, A. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039935 · Cited by 207 · see citing works
Chronic stress impairs rat growth and jejunal epithelial barrier function: role of mast cells
Santos, J., Benjamin, M. A., Yang, P., Prior, T., & Perdue, M. H. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.278.6.g847 · Cited by 205 · see citing works
Labanski, A., Langhorst, J., Engler, H., & Elsenbruch, S. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104501 · Cited by 200 · see citing works
Piche, T., Saint-Paul, M. C., Dainese, R., Marine-Barjoan, E., Iannelli, A., Montoya, M. L., Peyron, J. F., Czerucka, D., Cherikh, F., Filippi, J., et al. (2008) · Gut · doi:10.1136/gut.2007.127068 · Cited by 198 · see citing works
Murray, C. D. R., Flynn, J., Ratcliffe, L., Jacyna, M. R., Kamm, M. A., & Emmanuel, A. V. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.08.057 · Cited by 185 · see citing works
Stress and the gut microbiota-brain axis
Molina‐Torres, G., Rodríguez-Arrastia, M. J., Román, P., Sánchez‐Labraca, N., & Cardona, D. (2019) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000478 · Cited by 186 · see citing works
“Chronic stress is associated with gastrointestinal (GI) disorders such as irritable bowel syndrome (IBS) (Moloney et al., 2016).”
InfluentialZernicke, K. A., Campbell, T. S., Blustein, P. K., Fung, T. S., Johnson, J. A., Bacon, S. L., & Carlson, L. E. (2013) · International Journal of Behavioral Medicine · doi:10.1007/s12529-012-9241-6 · Cited by 178 · see citing works
Diop, L., Guillou, S., & Durand, H. (2008) · Nutrition Research · doi:10.1016/j.nutres.2007.10.001 · Cited by 162 · see citing works
Moloney, R. D., O’Mahony, S. M., Dinan, T. G., & Cryan, J. F. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00015 · Cited by 167 · see citing works
Psychological comorbidity in gastrointestinal diseases: Update on the brain-gut-microbiome axis
Person, H., & Keefer, L. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110209 · Cited by 158 · see citing works
“[PubMed: 31056802] Mikocka-Walus A, Pittet V, Rossel JB, von Kanel R, Swiss IBDCSG, 2016.”
BackgroundInfluentialStasi, C., Rosselli, M., Bellini, M., Laffi, G., & Milani, S. (2012) · Journal of Gastroenterology · doi:10.1007/s00535-012-0627-7 · Cited by 148 · see citing works
Bardin, L., Malfetes, N., Newman‐Tancredi, A., & Depoortère, R. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.07.005 · Cited by 146 · see citing works
The Effect of Life Stress on Symptoms of Heartburn
Naliboff, B. D., Mayer, M., Fass, R., FitzGerald, L., Chang, L., Bolus, R. R., & Mayer, E. A. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000124756.37520.84 · Cited by 146 · see citing works
Mayer, E. A., Tillisch, K., & Bradesi, S. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.03078.x · Cited by 139 · see citing works
Mechanisms of initiation and perpetuation of gut inflammation by stress
Hart, A., & Kamm, M. A. (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2002.01359.x · Cited by 138 · see citing works
O’Malley, D., Quigley, E. M. M., Dinan, T. G., & Cryan, J. F. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.04.009 · Cited by 139 · see citing works
Role of the gut microbiome in three major psychiatric disorders
Borkent, J., Ioannou, M., Laman, J. D., Haarman, B. C. M., & Sommer, I. E. (2022) · Psychological Medicine · doi:10.1017/s0033291722000897 · Cited by 132 · see citing works
Camilleri, M., Heading, R. C., & Thompson, W. (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2002.01305.x · Cited by 134 · see citing works
Ng, Q. X., Soh, A. Y. S., Loke, W., Venkatanarayanan, N., Lim, D. Y., & Yeo, W. (2019) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.14446 · Cited by 134 · see citing works
Choung, R. S., Locke, G. R., Zinsmeister, A. R., Schleck, C. D., & Talley, N. J. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.239 · Cited by 129 · see citing works
Alonso, C., Guilarte, M., Vicario, M., Ramos, L., Ramadan, Z., Antolín, M., Martínez, C., Rezzi, S., Saperas, E., Kochhar, S., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.036 · Cited by 128 · see citing works
Stereotaxic delivery of corticosterone to the amygdala modulates colonic sensitivity in rats
Meerveld, B. G., Gibson, M. S., Gunter, W., Shepard, J. D., Foreman, R. D., & Myers, D. A. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03305-9 · Cited by 125 · see citing works
Cognitive-behavioral therapy for patients with irritable bowel syndrome: current insights
Kinsinger, S. W. (2017) · Psychology Research and Behavior Management · doi:10.2147/prbm.s120817 · Cited by 119 · see citing works
Catecholamines Modulate Escherichia coli O157:H7 Adherence to Murine Cecal Mucosa
Chen, C., Brown, D. R., Xie, Y., Green, B. T., & Lyte, M. (2003) · Shock · doi:10.1097/01.shk.0000073867.66587.e0 · Cited by 118 · see citing works
Role of Corticotropin-releasing Factor in Gastrointestinal Permeability
Rodiño‐Janeiro, B. K., Alonso, C., Pigrau, M., Lobo, B., Vicario, M., & Santos, J. (2014) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm14084 · Cited by 119 · see citing works
Food hypersensitivity and irritable bowel syndrome
Zar, S., Kumar, D., & Benson, M. J. (2001) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2001.00951.x · Cited by 114 · see citing works
Reber, S. O. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.05.014 · Cited by 115 · see citing works
“In line, Bennett et al. (1998) provided evidence in a longitudinal human study that the presence of a highly threatening chronic stressor inhibits improvement from IBS, while its reduction or absence may be a prerequisite for a significant improvement of the disease.”
Ponferrada, Á., Caso, J. R., Alou, L., Rodríguez, A. C., Sevillano, D., Moro, M. Á., Lizasoaín, I., Menchén, P. L., Gómez-Lus, M. L., Lorenzo, P. L., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.02.032 · Cited by 111 · see citing works
Guthrie, E., Creed, F. H., Fernandes, L., Ratcliffe, J., der Jagt, J. V., Martin, J., Howlett, S., Read, N., Barlow, J. D., Thompson, D., et al. (2003) · Gut · doi:10.1136/gut.52.11.1616 · Cited by 112 · see citing works
Durbán, A., Abellan, J. J., Jiménez‐Hernández, N., Salgado, P., Ponce, M., Ponce, J. D. C., Garrigues, V., Latorre, A., & Moyá, A. (2012) · Environmental Microbiology Reports · doi:10.1111/j.1758-2229.2012.00327.x · Cited by 110 · see citing works
Mechanisms of Stress-induced Visceral Pain
Meerveld, B. G., & Johnson, A. C. (2018) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm17137 · Cited by 109 · see citing works
Vicario, M., Guilarte, M., Alonso, C., Yang, P., Martínez, C., Ramos, L., Lobo, B., González-Castro, A. M., Guilà, M., Pigrau, M., et al. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.06.002 · Cited by 108 · see citing works
Kennedy, P. J., Clarke, G., O‘Neill, A., Groeger, J. A., Quigley, E. M. M., Shanahan, F., Cryan, J. F., & Dinan, T. G. (2014) · Psychological Medicine · doi:10.1017/s0033291713002171 · Cited by 106 · see citing works
Seiler, A., von Känel, R., & Slavich, G. M. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.565239 · Cited by 110 · see citing works
“In addition, chronic life stressors such as financial problems, unemployment, and loss have been associated with an increased risk of developing functional gastrointestinal disorders, such as irritable bowel syndrome (147, 148).”
BackgroundWinston, J. H., Xu, G., & Sarna, S. K. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.09.054 · Cited by 100 · see citing works
Postinfectious Irritable Bowel Syndrome
Ericsson, C. D., Hatz, C., & DuPont, A. W. (2008) · Clinical Infectious Diseases · doi:10.1086/526774 · Cited by 99 · see citing works
Pain Catastrophizing and interpersonal problems: a circumplex analysis of the communal coping model
Lackner, J. M., & Gurtman, M. B. (2004) · Pain · doi:10.1016/j.pain.2004.04.011 · Cited by 96 · see citing works
“The comprehensiveness of the IIP lends itself to the study of interpersonal processes of chronic pain disorders like IBS whose patients experience various interpersonal problems (Bennet et al., 1998; Bennett and Kellow, 2002).”
BackgroundBoyd, C., Abraham, S., & Kellow, J. (2005) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520510015836 · Cited by 113 · see citing works
Self-citationRole of CRF receptor 1 in central CRF-induced stimulation of colonic propulsion in rats
Martı́nez, V., & Taché, Y. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03277-7 · Cited by 98 · see citing works
Role of the brain and sensory pathways in gastrointestinal sensory disorders in humans
Mertz, H. (2002) · Gut · doi:10.1136/gut.51.suppl_1.i29 · Cited by 94 · see citing works
Vicario, M., Alonso, C., Guilarte, M., Serra, J., Martínez, C., González-Castro, A. M., Lobo, B., Antolín, M., Andreu, A. L., García-Arumí, E., et al. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.05.005 · Cited by 92 · see citing works
“…not clear yet whether psychological stress induces GI disease by itself or is a consequence of it in IBS, it is well established that life stress can modify physiological and psychological responses that may precipi- tate abdominal distress, as well as psychiatric disorders (Bennett et al., 1998).”
BackgroundStress-Related Alterations of Visceral Sensation: Animal Models for Irritable Bowel Syndrome Study
Larauche, M. H., Mulak, A., & Taché, Y. (2011) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2011.17.3.213 · Cited by 92 · see citing works
Neurobiology of Stress-Induced Hyperalgesia
Olango, W. M., & Finn, D. P. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_302 · Cited by 90 · see citing works
“Stress amplifies nociception in irritable bowel syndrome (IBS), headaches and abdominal pain (Bennett et al. 1998; Boey and Goh 2002; Alfven et al. 2008).”
BackgroundSavas, L. S., White, D. L., Wieman, M. S., Daci, K., Fitzgerald, S. J., SMITH, S. L., Tan, G., Graham, D. P., Cully, J. A., & EL‐SERAG, H. B. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03847.x · Cited by 90 · see citing works
Mertz, H. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01447.x · Cited by 90 · see citing works
Impact of Shiftwork on Irritable Bowel Syndrome and Functional Dyspepsia
Kim, H. I., Jung, S.-A., Choi, J. Y., Kim, S., Jung, H., Shim, K., & Yoo, K. (2013) · Journal of Korean Medical Science · doi:10.3346/jkms.2013.28.3.431 · Cited by 88 · see citing works
Stigma and irritable bowel syndrome: a taboo subject?
Hearn, M., Whorwell, P. J., & Vasant, D. H. (2020) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(19)30348-6 · Cited by 88 · see citing works
Brain and Gut Interactions in Irritable Bowel Syndrome: New Paradigms and New Understandings
Coss‐Adame, E., & Rao, S. S. C. (2014) · Current Gastroenterology Reports · doi:10.1007/s11894-014-0379-z · Cited by 89 · see citing works
Irritable bowel syndrome: diagnosis and management
Agrawal, A., & Whorwell, P. J. (2006) · BMJ · doi:10.1136/bmj.332.7536.280 · Cited by 86 · see citing works
Clinical reviews in allergy and immunology
Leung, D. Y. M., Ledford, D. K., Wechsler, M. E., Fulkerson, P. C., Bochner, B. S., Gauvreau, G. M., Gleich, G. J., Henkel, T., Kolbeck, R., Mathur, S. K., et al. (2012) · Cited by 87 · see citing works
Personality traits and emotional patterns in irritable bowel syndrome
Muscatello, M. R. A., Bruno, A., Mento, C., Pandolfo, G., & Zoccali, R. A. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i28.6402 · Cited by 90 · see citing works
Larauche, M. H., Bradesi, S., Million, M., McLean, P. G., Taché, Y., Mayer, E. A., & McRoberts, J. A. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00507.2007 · Cited by 84 · see citing works
Daily Stress and Gastrointestinal Symptoms in Women With Irritable Bowel Syndrome
Hertig, V. L., Cain, K. C., Jarrett, M. E., Burr, R. L., & Heitkemper, M. M. (2007) · Nursing Research · doi:10.1097/01.nnr.0000299855.60053.88 · Cited by 84 · see citing works
Li, Y., Song, Z., Kerr, K. A., & Moeser, A. J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171617 · Cited by 84 · see citing works
- Authors
- Bennett, E. J., Tennant, C. C., Piesse, C., Badcock, C.-A., & Kellow, J. E.
- Affiliations
- Royal North Shore Hospital (AU)
- Corresponding author
- Kellow, J E
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1998-08-01
- Volume
- 43
- Issue
- 2
- Pages
- 256-261
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1727204
- OpenAlex
- W2101601471
- Cited by
- 405
- References
- 35
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 5 · 2021: 11 · 2020: 10 · 2019: 14 · 2018: 9 · 2017: 10 · 2016: 11 · 2015: 7 · 2014: 23 · 2013: 20 · 2012: 21
- FWCI
- 13.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Health Professions › Pharmacy › Infant Health and Development
- Keywords
- irritable bowel syndrome, functional dyspepsia, symptom intensity, clinical outcomes, symptom exacerbation
- MeSH terms
- Adult, Chronic Disease, Colonic Diseases, Functional, Emotions, Female, Humans, Male, Personality, Prognosis, Prospective Studies, Stress, Psychological, Time Factors, Age Distribution, Sex Distribution
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